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Application of porous magnesium alloy as carrier in medicine

A technology of porous magnesium and alloy, applied in the fields of bone repair and bone support materials, medical drug-loaded porous magnesium alloys, and cardiovascular stents, can solve the problems of high toxicity, large side effects, large injection dose, etc., to achieve convenient drug loading, mechanical Effects with adjustable performance, easily controllable shape and size

Inactive Publication Date: 2017-01-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preventing postoperative infection by injecting antibiotics has the disadvantages of large injection dose, high toxicity, and large side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The porous magnesium is prepared by corrosion pore-forming method, the pore size of the porous magnesium is 100 μm, the porosity is 30%, the strength is 100 MPa, and the elastic modulus is 20 GPa. Using laser cladding to load tantalum powder in the pores and surface of porous magnesium, the drug loading is 1mg / cm 3 , Tantalum has excellent biocompatibility, which can effectively improve the osseointegration ability of the material. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 2

[0031] The porous magnesium is prepared by corrosion pore-forming method, the pore size of the porous magnesium is 300 μm, the porosity is 50%, the strength is 50 MPa, and the elastic modulus is 11 GPa. The hydroxyapatite slurry is loaded into the holes and then solidified. The hydroxyapatite has excellent biocompatibility and can promote the formation of a firm combination between the implant and the bone. The material can meet the needs of bone filling, bone transplantation and bone repair.

Embodiment 3

[0033] The porous magnesium is prepared by corrosion pore-forming method. The porous magnesium has a pore size of 500 μm, a porosity of 70%, a strength of 20 MPa and an elastic modulus of 5 GPa. Load silver ions in the pores and on the surface of the material, the drug loading is 2mg / cm 3 , Silver ions have a good antibacterial effect, which can prevent postoperative infection and reduce the chance of surgical failure. The material can meet the needs of bone filling, bone transplantation and bone repair.

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PUM

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Abstract

The invention relates to application of a porous magnesium alloy as a carrier in medicine. Drugs can be carried onto the porous magnesium alloy to be used as a blood vessel stent, bone repair or bone propping material. The porous magnesium alloy is prepared by direct foaming, corrosion pore forming, laser drilling, powder metallurgy, quick forming, co-permeation vibration, 3D printing and the like. Laser cladding, microarc oxidation, anode oxidation, osmosis, embedding, solvent evaporation drying, melting, adsorption equilibrium and the like are performed to carry drugs into the porous magnesium alloy surface or the inside of the porous structure, thereby performing the functions of increasing the surface activity, promoting the bone cell growth and differentiation, preventing infection, implementing specific drug delivery and partial drug delivery and the like. The preparation method is simple to operate and easy to implement, and has the advantages of controllable structure, convenient drug carrying, firm drug combination, low cost and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a medical drug-loaded porous magnesium alloy, which is mainly used in the aspects of cardiovascular support, bone repair and bone support materials. Background technique [0002] Magnesium alloy is currently a research hotspot in the field of biomedical degradable metal implant materials. Magnesium alloy has the following advantages: 1. Magnesium alloy has good biocompatibility; 2. Magnesium is one of the constant elements in the human body after calcium, sodium and potassium, which can activate a variety of enzymes and participate in a series of metabolic processes in the body , to promote the deposition of calcium, which is an essential element for bone growth; 3. Magnesium alloy has good mechanical compatibility, its density is close to that of natural bone, and its elastic modulus is about 41-45GPa, which is closer to that of human bone. Relieve the stress shielding effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/54A61L27/56A61L27/58A61L31/02A61L31/14A61L31/16
CPCA61L27/047A61L27/54A61L27/56A61L27/58A61L31/022A61L31/146A61L31/148A61L31/16A61L2300/104A61L2300/216A61L2300/252A61L2300/404A61L2300/406A61L2300/412A61L2300/414A61L2300/416
Inventor 何国李秋炎
Owner SHANGHAI JIAO TONG UNIV
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