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Vascular stent with degradable drug-loaded coating and preparation method thereof

A drug-loaded coating and vascular stent technology, which is applied in the field of medical devices to achieve the effects of improving binding force, increasing loading rate, and avoiding restenosis

Inactive Publication Date: 2016-08-31
BEIJING UNION UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this patent, a polymer is used as a drug-loaded coating, so there are the above-mentioned defects caused by the polymer

Method used

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  • Vascular stent with degradable drug-loaded coating and preparation method thereof
  • Vascular stent with degradable drug-loaded coating and preparation method thereof
  • Vascular stent with degradable drug-loaded coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 : A vascular stent with a degradable drug-loaded coating—ion beam-assisted deposition method

[0051] The preparation method of the vascular stent with the degradable drug-loaded coating described in this embodiment comprises the following steps:

[0052] (1) Vascular stent cleaning: ultrasonically clean the cobalt-chromium alloy stent in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dry.

[0053] (2) Preparation of calcium-phosphorus transition layer: the cleaned cobalt-chromium alloy stent was placed in a vacuum device for ion beam-assisted deposition, and a calcium-phosphorus coating with a higher Ca / P ratio was prepared by adding 37% CaO powder to HA powder. layer. Use an electron beam evaporator and an ion gun in the form of a spherical port. Before deposition, the substrate was cleaned by 120V, 2A argon ion beam sputtering for 20min to obtain a suitable vacuum degree (basic pressure 2 × 10−7Torr). ...

Embodiment 2

[0057] Example 2 : A vascular stent with a degradable drug-loaded coating—electrochemical deposition

[0058] The preparation method of the vascular stent with the degradable drug-loaded coating described in this embodiment comprises the following steps:

[0059] (1) Vascular stent cleaning: ultrasonically clean the nickel-titanium alloy stent in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dry.

[0060] (2) Preparation of calcium-phosphorus transition layer: use constant current deposition mode, and control the current density to about 1.0mA / cm2; use the acid-etched nickel-titanium alloy stent as the cathode of the electrochemical reaction, and use platinum as the counter electrode; electrolyte It is a mixed solution of 10-4mol / l CaCl2 and Na2HPO4, the pH is adjusted between 5.5-7.0, and it is deposited under boiling conditions, and the deposition time is 10-60 minutes.

[0061] (3) Prepare regenerative drug-loaded coati...

Embodiment 3

[0063] Example 3 : A kind of vascular stent with degradable drug-loaded coating—plasma spraying method

[0064] The preparation method of the vascular stent with the degradable drug-loaded coating described in this embodiment comprises the following steps:

[0065] (1) Vascular stent cleaning: ultrasonically clean the cobalt-chromium alloy stent in acetone for 10 min, then in ethanol for 10 min, and finally in deionized water for 10 min, and dry.

[0066] (2) Preparation of calcium-phosphorus transition layer: preparation of the transition layer: put the stainless steel bracket into the plasma spraying device, and the coating composition is high-purity hydroxyapatite. The main process parameters are as follows: main gas: argon 80scfh, secondary gas: hydrogen 8scfh, spraying current: 500A, spraying voltage: 50V, spraying distance: 150mm. The obtained transition layer has a thickness of 80 μm and a bond strength of 75 MPa with the substrate.

[0067] (3) Preparation of re...

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Abstract

The invention relates to a vascular stent with a degradable drug-loaded coating and a preparation method thereof. The vascular stent includes a stent body, and also includes a calcium-phosphorus transition layer and a regenerated drug-loaded coating. The calcium-phosphorus transition layer is located on the surface of the stent body, the regenerated drug-loaded coating is located on the surface of the calcium-phosphorus transition layer, and the regenerated drug-loaded coating and the calcium-phosphorus transition layer have same ingredients and fix drugs. The contribution of the invention lies in that the vascular stent can fix drugs in a biodegradable coating without using polymer, and can control drug release by adjusting the regenerated drug-loaded coating. The experimental result shows that the polymer-free degradable drug-loaded coating can effectively inhibit vascular intimal hyperplasia and avoids the occurrence of restenosis.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a blood vessel stent with a degradable drug-loaded coating and a preparation method thereof. Background technique [0002] With the advent of percutaneous angioplasty (PCI) in the late 1970s and vascular stents in the late 1980s, restenosis has always been an important defect of PCI. The emergence of drug-loaded cardiovascular stents has greatly reduced the occurrence of restenosis. The previously used inert coatings, vascular deposition and long-term adverse effects of non-degradable polymeric carrier materials have also raised many new problems. The current commonly used drug-coated stent preparation method is to make a mixed solution of polymers, mostly polylactic acid and its copolymers, and drugs that inhibit restenosis, and apply it to the surface of the vascular stent. After the solvent dries, it will form on the surface of the stent. A polymer drug coating. Howev...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/14A61L31/16
CPCA61L31/086A61L31/088A61L31/146A61L31/148A61L31/16A61L2300/416A61L2300/602A61L2300/604A61L2300/608A61L2420/08
Inventor 杨静馨马永新徐平国王训伟万春萍
Owner BEIJING UNION UNIVERSITY
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