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Application of chlorogenic acid nano powder inhalation in medicine for treating acute lung injury

A technology for acute lung injury and chlorogenic acid, applied in the field of medicine, can solve the problem that there is no specific drug for acute lung injury

Inactive Publication Date: 2016-08-31
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no clinically effective drug for acute lung injury

Method used

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  • Application of chlorogenic acid nano powder inhalation in medicine for treating acute lung injury
  • Application of chlorogenic acid nano powder inhalation in medicine for treating acute lung injury
  • Application of chlorogenic acid nano powder inhalation in medicine for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1. Chlorogenic acid liposome powder spray

[0043] Take 80mg of chlorogenic acid, 300mg of soybean lecithin, and 20mg of cholesterol in an eggplant-shaped bottle, add 10ml of ethanol and heat for a while to dissolve completely, inject it into 50ml of 40°C water with a 1ml syringe, stir while injecting, and ultrasonically disperse for 10 minutes after injection , and remove most of the ethanol under reduced pressure at 37°C to obtain a chlorogenic acid liposome suspension. The chlorogenic acid liposome is spray-dried to obtain the chlorogenic acid liposome powder. The spray drying parameters are as follows: air inlet temperature: 100°C, air outlet temperature: 50°C, fan power: 55Hz, peristaltic pump speed: 280mL / h, firing pin interval: 2 seconds.

[0044] Electron micrographs show chlorogenic acid liposomes before spray drying ( figure 1 ) and chlorogenic acid liposome powder aerosol reconstitution suspension ( figure 2 ) are in the shape of a regular sphe...

Embodiment 2

[0045] Embodiment 2. Chlorogenic acid solid lipid nanoparticle powder spray

[0046] Take 50mg of chlorogenic acid, 0.7g of glyceryl monostearate, and 800.03g of Tween in a beaker and heat to 80°C, gradually add 10ml of 80°C water containing 10mg of sodium lauryl sulfate, keep the temperature constant, and turn transparent Liquid; inject it into high-speed stirred water containing 1.2g of lactose at 0°C with a syringe, and it becomes a transparent liquid; observed under a scanning electron microscope, most of the particles are below 100 nanometers. The chlorogenic acid solid lipid nanoparticle is spray-dried to obtain the chlorogenic acid solid lipid nanoparticle powder spray. The spray drying parameters are as follows: air inlet temperature: 100°C, air outlet temperature: 50°C, fan power: 55Hz, peristaltic pump speed: 280mL / h, firing pin interval: 2 seconds.

Embodiment 3

[0047] Embodiment 3. Chlorogenic acid nano-emulsion powder mist

[0048] Dissolve 50 mg of chlorogenic acid in 5 ml of ethyl oleate / ethanol mixed solvent, add appropriate amount of polyoxyethylene castor oil and monoglyceride, heat and stir to form a solution, add about 4 ml of water under high-speed stirring conditions, and continue stirring to obtain Translucent dispersion liquid. The results of particle size measurement show that most of the particles are below 120nm, which is chlorogenic acid nanoemulsion. Get 100mg of mannitol and add it into 4ml of chlorogenic acid nanoemulsion for dissolving, freeze-dry in a lyophilizer to obtain chlorogenic acid nanoemulsion powder with good fluidity. Take 100 mg of chlorogenic acid nano-emulsion powder and mix with 100 mg of Inhalac230 lactose produced by Meggle to obtain chlorogenic acid nano-emulsion powder spray.

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Abstract

The invention discloses an application of a chlorogenic acid nano powder inhalation in a medicine for treating acute lung injury. The chlorogenic acid nano powder inhalation is prepared with a chlorogenic acid nano medicine delivery system selected from the dosage forms of lipidosomes, nano-particles, nano-emulsions and micro-emulsions with or without addition of an auxiliary material. The medicine delivery system is dried into solid powder and is then mixed with a carrier to prepare the chlorogenic acid nano powder inhalation. The nano powder inhalation is stable, is easy to enter the deep parts of lung tissue, allows targeted positioning, is convenient to carry and use and has advantages on treatment of the acute lung injury. The chlorogenic acid nano powder inhalation is used for treating acute lung injuries caused by infection, shock, smoking, wound, poisoning, inhalation of simulative gas, irradiation, high-oxygen and low-oxygen atmospheres and the like. The simulative gas herein comprises phosgene, diphosgene, triphosgene, chlorine, nitrogen oxides, formaldehyde, dimethyl sulfate, hydrogen chloride, hydrogen bromide, hydrogen fluoride, ammonia, ozone and sulfur dioxide.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a chlorogenic acid nanopowder aerosol and its application in medicine for treating acute lung injury. Background technique [0002] Chlorogenic acid is widely distributed in plants, ranging from higher dicotyledonous plants to ferns. It mainly exists in Lonicera genus, Artemisia genus Asteraceae and Eucommia genus Eucommia. Kernels, cocoa beans, coffee beans, sea buckthorn berries and traditional Chinese herbal medicines such as honeysuckle and Eucommia. The chemical name of chlorogenic acid is 3-O-caffeophthaloquinic acid. The solubility in water is 4%. It is easily soluble in ethanol and acetone, slightly soluble in ethyl acetate, and hardly soluble in lipophilic organic solvents such as chloroform, ether, and benzene. , is a pale yellow solid. At present, it has been found that chlorogenic acid has antibacterial, antiviral, liver-protecting and choleretic, anti-tumor, blood pressure-...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/12A61K9/14A61K9/107A61K9/127A61K31/216A61P11/00
CPCA61K9/1075A61K9/12A61K9/127A61K9/14A61K31/216
Inventor 佟丽魏群金义光王梦奇尹艳霞骆静向本琼
Owner BEIJING NORMAL UNIVERSITY
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