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Terbinafine hydrochloride compound sustained-release capsule and preparation method and application

A technology of terbinafine hydrochloride and sustained-release capsules, which is applied in the field of medicine, can solve problems such as fungal cell death and ergosterol deficiency, and achieve the effects of stable blood drug concentration, high effective ratio of drugs, and simple formula

Inactive Publication Date: 2016-03-23
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Terbinafine hydrochloride specifically interferes with the early steps of fungal sterol biosynthesis, thereby causing ergosterol deficiency and intracellular accumulation of squalene, leading to fungal cell death

Method used

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  • Terbinafine hydrochloride compound sustained-release capsule and preparation method and application
  • Terbinafine hydrochloride compound sustained-release capsule and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A compound sustained-release capsule of terbinafine hydrochloride. The components and parts by weight of the sustained-release capsule include: 5 parts of terbinafine hydrochloride, 50 parts of seaweed, 35 parts of Cyperus cyperi, 20 parts of Amomum chinensis, and 40 parts of licorice 30 parts of myrrh, 20 parts of herb, 35 parts of dried hemp, 35 parts of cicada slough, 25 parts of water hyacinth fruit, 20 parts of flower ant insect, 30 parts of jerky beetle, 3 parts of sucrose pill, 0.3 part of ethyl cellulose , 0.08 parts of glycerides, 0.05 parts of polyethylene glycol, 2 parts of microcrystalline cellulose, and 1 part of talcum powder.

[0030] A preparation method of terbinafine hydrochloride compound sustained-release capsules, comprising the steps of:

[0031] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound sustained-release capsule, wherein terbinafine hydrochloride is pulverize...

Embodiment 2

[0039] A compound sustained-release capsule of terbinafine hydrochloride. The components and parts by weight of the sustained-release capsule include: 10 parts of terbinafine hydrochloride, 60 parts of seaweed, 40 parts of Cyperus cyperi, 25 parts of Amomum chinensis, and 45 parts of licorice 35 parts of myrrh, 25 parts of atractylodes atractylodes, 40 parts of dried hemp, 40 parts of cicada slough, 30 parts of water hyacinth fruit, 25 parts of flower ant insects, 35 parts of gillworms, 5 parts of sucrose pills, 0.5 parts of ethyl cellulose , 0.1 part of glyceride, 0.08 part of polyethylene glycol, 4 parts of microcrystalline cellulose, and 2 parts of talcum powder.

[0040] A preparation method of terbinafine hydrochloride compound sustained-release capsules, comprising the steps of:

[0041] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound sustained-release capsule, wherein terbinafine hydroch...

Embodiment 3

[0049] A compound sustained-release capsule of terbinafine hydrochloride. The components and parts by weight of the sustained-release capsule include: 7 parts of terbinafine hydrochloride, 56 parts of seaweed, 39 parts of Cyperus cyperi, 21 parts of Amomum japonicus, 43 parts of licorice 34 parts of myrrh, 22 parts of herb, 36 parts of dried hemp, 38 parts of cicada slough, 29 parts of water hyacinth fruit, 23 parts of flower ant insect, 34 parts of jerky beetle, 4 parts of sucrose pill, 0.4 part of ethyl cellulose , 0.09 parts of glycerides, 0.06 parts of polyethylene glycol, 3 parts of microcrystalline cellulose, and 1.2 parts of talcum powder.

[0050] A preparation method of terbinafine hydrochloride compound sustained-release capsules, comprising the steps of:

[0051] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound sustained-release capsule, wherein terbinafine hydrochloride is pulverized...

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Abstract

The invention discloses a terbinafine hydrochloride compound sustained-release capsule and a preparation method and application. The compound sustained-release capsule is prepared from terbinafine hydrochloride, seaweeds, rhizoma cyperi, amomun fruit, licorice roots, myrrh, rhizoma atractylodis, root of angled bittersweet, periostracum cicada, seeds of common sterculia, yellow ants, buprestid beetles, saccharose pills, ethyl cellulose, glyceride, polyethylene glycol, microcrystalline cellulose and talcum powder. The preparation method comprises the steps of material preparation, extraction of traditional Chinese medicine active pharmaceutical ingredients, preparation of drug-containing pill cores of the traditional Chinese medicine active pharmaceutical ingredients, preparation of sustained-release minipills of the traditional Chinese medicine active pharmaceutical ingredients, preparation of terbinafine hydrochloride minipills and capsule filling. According to the compound sustained-release capsule, the toxic and side effects of the terbinafine hydrochloride are overcome, compatibility of the raw materials is appropriate, the efficacy is quick, the curative effect is good, use is convenient, the drug effective ratio is high, lasting and slow release of the drugs can be achieved in vivo, the blood concentration is smooth and steady, fluctuation is small, certain protection to visceral organs of a patient is achieved, and compliance of the patient is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a terbinafine hydrochloride compound sustained-release capsule, a preparation method and application. Background technique [0002] Terbinafine hydrochloride is an allylamine antifungal drug, which inhibits squalene cyclooxygenase in the process of ergosterol synthesis in fungal cells, and makes squalene accumulate in cells to play a bactericidal effect. The sensitivity of human cells to terbinafine hydrochloride is one ten thousandth of that of fungi. It has a broad-spectrum antifungal effect, has a bactericidal effect on skin fungi, and has a bacteriostatic effect on Candida albicans. It is suitable for skin and nail infections caused by superficial fungi, such as tinea corporis, jock itch, athlete's foot, onychomycosis, and skin Candida albicans infections caused by Trichophyton, Microsporum canis, and Epidermophyton flocculus. Terbinafine hydrochloride specifica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/52A61P31/10A61P17/00A61P1/14A61P1/08A61K31/137A61K35/64
CPCA61K31/137A61K9/0002A61K9/5084A61K36/03A61K36/185A61K36/284A61K36/328A61K36/37A61K36/484A61K36/8905A61K36/9064A61K47/36A61K2236/331A61K2236/39A61K2300/00
Inventor 王芬黄清华赵田孙强
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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