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Preparation method of medicine-carrying soft corneal contact lens

A technology for soft corneas and contact lenses, applied in glasses/goggles, instruments, optics, etc., can solve the problems of low bioavailability, short drug release cycle, and decreased light transmittance, and achieve strong and stable light transmittance release effect

Active Publication Date: 2015-05-06
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Drug-loaded soft contact lenses, as a new type of ocular surface drug delivery system, are now attracting more and more attention. The traditional preparation method of drug-containing contact lenses includes directly soaking traditional contact lenses in liquid medicine, and Contact lenses after monomer polymerization have been soaked to load drugs, disperse or fix drug-containing micelles and nanoparticles to the surface of contact lenses, and molecular imprinting, etc., but they still have short drug release periods, low bioavailability, and permeability. How to prepare a soft contact lens that can delay the drug release cycle without affecting the visibility is an urgent problem to be solved in the drug-loaded soft contact lens system.

Method used

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  • Preparation method of medicine-carrying soft corneal contact lens
  • Preparation method of medicine-carrying soft corneal contact lens
  • Preparation method of medicine-carrying soft corneal contact lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Dissolve β-hydroxyethyl methacrylate prepolymer, ethylene glycol methacrylate, azobisisobutyronitrile and diclofenac sodium in methanol, stir evenly, and apply the slurry on such as figure 1 on the gray area of ​​the round hole of the plate shown, which is then transfer printed onto a figure 2 The surface of the male mold shown is then placed in an oven at 120°C and cured for 60 minutes; repeat the above operations to obtain different layers of the drug film;

[0035] After mixing β-ethyl methacrylate, methacrylic acid, N-vinylpyrrolidone, ethylene glycol methacrylate and azobisisobutyronitrile evenly, pipette the above mixed solution and place it in figure 2 Then insert the male mold printed with the drug film into the female mold, place it in an oven at 90°C, and turn it into pieces after curing for 45 minutes to obtain the drug-loaded soft corneal contact mirror.

Embodiment 2

[0037] Add β-hydroxyethyl methacrylate prepolymer, ethylene glycol methacrylate, azobisisobutyronitrile and drugs to the solvent in sequence, and after stirring evenly, apply the resulting solution on a plate with round holes , forming a circular ring, and then transfer printing it to the upper surface of the positive mold, and then heat and cure it in an oven; repeat the above operations to obtain different layers of the drug film;

[0038] After mixing β-hydroxyethyl methacrylate, methacrylic acid, N-vinylpyrrolidone, ethylene glycol methacrylate and azobisisobutyronitrile evenly, pipette the above mixed solution and place it in the female mold. Then embed the upper surface of the male mold printed with the drug film obtained in step S1 into the concave surface of the female mold, put it in an oven for curing, and turn it into pieces to obtain the drug-loaded soft corneal contact mirror,

[0039] The male mold is a cylinder, and the upper surface of the cylinder...

Embodiment 3

[0050] In vitro release test: Soak the dry medicated lens of the drug-loaded soft contact lens obtained in Example 2 in 3ml of deionized water for 2 days to eliminate residual unreacted monomers, and then transfer to 3ml of fresh normal saline and placed in an air shaker at 37°C to release the drug by shaking, and the release liquid was replaced with fresh physiological saline at regular intervals every day, and the obtained release sample liquid was determined by HPLC method.

[0051] Figure 4 According to the method of Example 3, the concentration of the release sample solution obtained after the in vitro release test of the drug-loaded soft contact lens obtained in Example 2 is a graph showing the change in the number of days. It can be seen from the graph that the drug release cycle is long. , the sustained-release effect is stable, and since the central light-transmitting area is not modified and drug-coated during the drug release process, the transparency of the light-...

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Abstract

The invention discloses a preparation method of a medicine-carrying soft corneal contact lens. The preparation method comprises the following steps: sequentially adding a methylacrylic acid-beta-hydroxy ethyl acrylate prepolymer, ethylene glycol dimethyl acrylate (EGDMA), azodiisobutyronitrile (AIBN) and medicines into a solvent, uniformly stirring, coating the obtained slurry to a plate with a round hole, then transferring and printing the slurry to the surface of a male die, and then putting the plate into an oven, and heating and curing; repeating the operation to obtain a medicine film with different layers; and after uniformly mixing methylacrylic acid-beta-hydroxy ethyl acrylate (HEMA), methylacrylic acid, N-vinyl pyrrolidone (NVP), EGDMA and AIBN, weighing the mixed solution in a female die, then further embedding the male die printed with the medicine film into the female die, then putting the female die in the oven, curing, and turning to form a sheet to obtain the medicine-carrying soft corneal contact lens. The medicine-carrying soft corneal contact lens prepared by the preparation method disclosed by the invention is strong in transmission of light, long in drug sustained release period, stable to release and high in bioavailability.

Description

technical field [0001] The invention relates to the technical field of contact lenses, in particular to a method for preparing drug-loaded soft contact lenses. Background technique [0002] Drug-loaded soft contact lenses, as a new type of ocular surface drug delivery system, are now attracting more and more attention. The traditional preparation method of drug-containing contact lenses includes directly soaking traditional contact lenses in liquid medicine, and Contact lenses after monomer polymerization have been soaked to load drugs, disperse or fix drug-containing micelles and nanoparticles to the surface of contact lenses, and molecular imprinting, etc., but they still have short drug release periods, low bioavailability, and permeability. How to prepare a soft contact lens that can delay the drug release cycle without affecting the visibility is an urgent problem to be solved in the drug-loaded soft contact lens system. Contents of the invention [0003] The purpose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04C08F220/28C08F220/06C08F226/10C08F222/14C08F265/04
CPCC08F220/28C08F220/281C08F265/04G02C7/049C08F222/1006C08F226/10C08F220/06
Inventor 薛巍付业云施云峰吕红玲李沁华刘宗华陈松彬
Owner JINAN UNIVERSITY
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