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Sanhuang supper micropowder as well as preparing method and application thereof

A technology of ultra-fine powder and Sanhuang powder, which is applied in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of single processing and use of Chinese herbal medicines, affecting the quality and therapeutic effect of Chinese medicines, and insufficient release of active ingredients. and other issues, to achieve the effect of protecting the intestinal tract, easy to dissolve and absorb, and easy to implement

Inactive Publication Date: 2015-02-18
INST OF OCEANOLOGY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country has a long history of using Chinese herbal medicines to treat aquatic animal diseases, but the processing and use methods of Chinese herbal medicines for fishing are still very single, most of them are mainly coarsely crushed powders, or boiled and then splashed, resulting in large doses and rough dosage forms. , poor appearance and other deficiencies, the active ingredients cannot be fully released, and the bioavailability is low, which seriously affects the quality and therapeutic effect of traditional Chinese medicine, and restricts its clinical application

Method used

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  • Sanhuang supper micropowder as well as preparing method and application thereof
  • Sanhuang supper micropowder as well as preparing method and application thereof
  • Sanhuang supper micropowder as well as preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The superfine powder is calculated by weight percentage, 30% of Scutellaria baicalensis, 30% of Cortex Phellodendri, 30% of Rhubarb and 10% of Daqingye are mixed and pulverized to below 500 mesh.

[0025] Preparation:

[0026] (1) Drying: wash the raw materials of scutellaria baicalensis, Phellodendron phellodendron, rhubarb and Folium baicalensis, mix them according to the above ratio, and dry them at a constant temperature at 60°C to keep the water content below 8%; then make them into 3-5cm long sections spare.

[0027] (2) Coarse pulverization: Coarsely pulverize with a traditional Chinese medicine pulverizer and cross a 50-80 mesh sieve to obtain coarse powder;

[0028] (3) First-class ultrafine powder (impact mill ultrafine powder): The graded impact mill uses the violent impact of the hammer head on the high-speed rotating body and the material, and at the same time is impacted at the gap between the impact hammer head and the ring gear. , abrasion, shearing, t...

Embodiment 2

[0033] The clinical effect of the preparation of the present invention for the treatment of prawn white stool enteritis is verified by the following tests:

[0034] The shrimp pond in Qiaozhuang Town, Boxing County, Binzhou City, with an area of ​​11 mu and a density of 60,000 per mu. On August 4, 2013, the vannamei cultured there had white stools, jejunum and empty stomach, etc. Some swimming ponds were preliminarily judged to be enteritis caused by bacteria.

[0035]Inspection: only 1 of the 20 shrimps taken was detected with white spot syndrome virus, taura virus and infectious subcutaneous and hematopoietic organ necrosis virus were all negative; some prawns were seriously infected with Vibrio; Pancreatic ductal edema, glandular duct atrophy, shedding. Opening of the stomach and hepatopancreas, exfoliated ductal epithelium, exfoliated glandular epithelium in the gastric cavity, typical white intestine characteristics, yellow pigment on the surface, exfoliated epithelium i...

Embodiment 3

[0039] The clinical effect of preventing and treating California perch bacterial sepsis of preparation of the present invention is verified by following test:

[0040] 1. Purpose of the test

[0041] To evaluate the control effect of Sanhuangsan broken wall superfine powder on California perch bacterial sepsis.

[0042] 2. Test content

[0043] The effects of different concentrations of Sanhuangsan broken wall superfine powder on the clinical manifestations, survival rate, liver, spleen and kidney pathological characteristics of California perch artificially infected with Aeromonas hydrophila were detected by adding in the feed.

[0044] 3. Test time and place

[0045] The experiment was conducted from November 2013 to January 2014 at the Pearl River Fisheries Research Institute of the Chinese Academy of Fishery Sciences.

[0046] 4. Test material

[0047] 4.1 Test drugs

[0048] The Sanhuangsan broken-wall superfine powder prepared in the foregoing examples.

[0049] 4....

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Abstract

The invention relates to the field of fish medicine preparations, in particular to Sanhuang supper micropowder as well as a preparing method and applications thereof. The supper micropowder comprises in percentage by weight as follows: 25-35% of baical skullcap roots, 25-35% of amur cork tree bark, 25-35% of rhubarb and 5-10% of indigowoad leaves. The Sanhuang supper micropowder has effects of clearing heat, cooling blood, resisting viruses and detoxifying, plays powerful antibacterial, disinfection and antiviral roles in water bodies and pathogenic bacteria of aqueous animal (gills, body surfaces and the like) tissue and is particularly used for mainly treating bacterial enteritis caused by pseudomonas, vibrio, aeromonas hydrophila and Edwardsiella in the aqueous animals. Tests prove that the Sanhuang wall-breaking supper micropowder can improve and treat white excrement enteritis of penaeus vannamei boone and septicemia of Micropterus salmoides to a certain extent, can enhance the aeromonas hydrophlia infection resistance of the Micropterus salmoides and is a novel fish medicine for effectively protecting intestinal tracts and preventing bacterial enteritis in the aqueous animals, and the use amount can be significantly decreased by 2-3 times.

Description

technical field [0001] The invention relates to the field of fish medicine preparations, in particular to a superfine powder of Sanhuang powder and its preparation method and application. Background technique [0002] In recent years, with the continuous improvement of aquaculture intensification, the breeding density has increased day by day, and the occurrence of aquatic animal diseases has become more and more serious. There have been diseases mainly characterized by enteritis. Significantly, the posterior part of the midgut also becomes red or swollen, and the rectum (hindgut) becomes cloudy. Sick fish / shrimp are inactive, anorexia, and slow growth. This disease often occurs concurrently with bacterial gill rot and red skin disease. In severe cases, the mortality rate can reach more than 90%. The etiology has the following points: 1. The high breeding density can easily lead to the deterioration of the water environment; 2. The feed formula for intensive feeding is sing...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K36/855A61K9/14A61P31/04A61P1/00
CPCA61K36/539A61K9/14A61K36/195A61K36/315A61K36/704A61K36/708A61K36/756A61K36/855A61K2236/15
Inventor 王宝杰王安林王雷刘梅蒋克勇
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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