Rifaximin-containing pharmaceutical preparation

Abstract

The invention discloses a pharmaceutical preparation containing rifaximin gel and rifaximin oral emulsion and a preparation method thereof, wherein the gel comprises rifaximin and a gel matrix, the mass ratio of the rifaximin to the gel matrix is (2-80):(5-64), and the gel matrix comprises 2-30 parts by weight of a water-soluble gel matrix and 0.5-2 parts by weight of a modifier; and the rifaximin oral emulsion comprises 1-40 parts by weight of rifaximin, 50-350 parts by weight of an oil phase, 1-300 parts by weight of an emulsifier, and 0-150 parts by weight of a co-emulsifier. In the preparation, on the premise of guaranteeing that the dose of a main drug is appropriate, through the selection of auxiliary materials and preparation methods, rifaximin is prepared into gel or oral emulsion, thereby facilitating the oral administration and absorption of drugs, and achieving relatively high bioavailability. Meanwhile, a newer and better dosage form choice is provided for clinic.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical preparation containing rifaximin for treating intestinal infection and a preparation method thereof. Background technique [0002] Diarrhea is a common symptom that seriously threatens human health. It is considered to be one of the five common clinical symptoms and one of the top five killers of children. According to the WHO survey, 1.2 billion children under the age of five are infected with diarrhea every year, and 4,000,000 children die from diarrhea, especially in developing countries. Diarrhea is not only quite common among children under the age of 5, but also an important cause of death. In developed countries, each person suffers from 1-3 diarrheal diseases per year on average, and children in poor areas of tropical developing countries suffer from 5-18 diarrheal diseases per person per year on average, especially infectious diarrhea. In my c...

AI Technical Summary

Problems solved by technology

[0007] For tablets, when the dose for children is less than one tablet, artificial division is required, resulting in inaccurate dosage. Some coated tablets lose their specific functions such as protection, taste masking, controlled release, and isolation after artificial division. Dosage is not suitable for children to take, difficulty swallowing

[0008] For capsules, when children use less than one capsule, the method of pouring out the medicine in the capsule and taking it with water is often adopted. Capsules are generally large, which is even more unfavorable for children to take.

[0009] For dry suspension, if the dosage for children is less than the minimum packaging volume, it needs to be manually disassembled, resulting in inaccurate dosage. When taking it, it needs to be mixed with water, which is inconvenient to take outside.

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