Preparation method and application of hierarchical porous bioactive ceramic

Abstract

The invention discloses a preparation method and application of hierarchical porous bioactive ceramic. The preparation method comprises the following steps: mixing a binding agent, plasticizer and solvent to obtain an additive emulsion; adding a pore forming agent into the additive emulsion, and mixing to obtain a pore forming agent viscous liquid; adding bioactive powder into the pore forming agent viscous liquid, compounding, and aging to obtain high-plasticity mud pies; and performing extrusion molding on the mud pies, drying, sintering to obtain honeycombed hierarchical porous bioactive ceramic, grouting with a bioactive powder suspension to regulate the size and shape of pores, drying again, and firing to finally obtain the bioactive ceramic having a hierarchical pore size structure and a non-acute pore shape. According to the invention, the preparation method is simple; industrial production can be realized; and the hierarchical porous bioactive ceramic having the advantages of high porosity, favorable mechanical property, satisfactory connectivity and the like can be prepared and is an ideal bone defect repair material.

Description

technical field [0001] The invention relates to the field of medical materials for bone defect repair, in particular to a preparation method and application of a multi-level porous bioactive ceramic. Background technique [0002] Porous bioactive ceramics are ideal bone tissue replacement and repair materials, which can be directly used for filling and repairing bone defects, and can also be used as scaffolds for bone tissue engineering. Scholars have different views on the pore diameter suitable for bone tissue ingrowth. It is generally believed that the pore size distribution of 200-400 μm is suitable for bone tissue ingrowth, and can provide suitable mechanics for the adhesion of osteoblasts and tissue ingrowth. environment. For the ingrowth of bone tissue, a pore size greater than 100 μm is necessary, but more than 300 μm is more conducive to the growth of new bone and the formation of blood vessels (Porosity of 3D biomaterial scaffolds and osteogenesis, Karageorgiou V,...

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Problems solved by technology

However, these methods have their own advantages and disadvantages, such as the organic foam replica method (Permeability ofceramicfoams, Innocentini M D M, Salvini V R, Pandolfelli V C.Am Ceram Soc Bull, 1999,78:78.) can produce materials with high porosity, and The sample has higher strength after sintering, but the disadvantage is that it can only prepare network-shaped porous materials with large pore diameters (1000 μm or even larger), and it is difficult to prepare porous materials with pore diameters below 500 μm, and the material form is limited. The structure is not conducive to cell adhesion, proliferation, migration and new bone ingrowth

Materials with complex shapes can be prepared by adding pore-forming agents (Fabrication of hydroxyapatite ceramic with controlled porosity, Dean-Mo Liu. J Mater Sci Mater Med, 1997, 8: 227232.), and by adjusting the amount and particle size of pore-forming agents Porous materials with different pore structures can be prepared by using different diameters, and the pore diameters can be controlled within an appropriate range. However, the porous materials prepared by this method have poor pore distribution uniformity, unsatisfactory pore connectivity, and are not suitable for preparing products with high porosity.

The gas foaming method (Chemistry and sintering behave our ofthin hydroxyapatite ceramics with controlled porosity, Arita I H, Wilkinson D S, Mondragon M A, Castano V M. Biomaterials, 1995,16(5):403-408.) is especially suitable for the preparation of closed-pore ceramics material, and has the advantages of high porosity and high strength, but it is difficult for new bone to grow into unconnected closed pores, which is not good for bone repair, and the requirements for raw materials are high, and the process conditions are not easy to control

Rapid prototyping (Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs, Leong K F, Cheah C M, Chua C K. Biomaterials, 2003, 24: 2363-2378.) has a short molding time, is conducive to automated production, and has good reliability Designability, uniform pores, scaffolds with different pore structures can be prepared to meet the different requirements of composite tissues, the disadvantage is that the porosity of the scaffold is low, usually less than 80%, and due to technological limitations, the prepared pores are too large , the mechanical properties also need to be improved

The particle leaching method (Biodegradable HA-PLA 3-D porous scaffolds. Effect of nano-sized filler content on scaffold properties, Kothapalli C R, Shaw M T, Wei M. Acta Biomater, 2005, 1:653-662.) has a simple process, The pore size is easy to control in an appropriate range, but the disadvantage is that the post-treatment is more troublesome, it is not easy to completely remove the soluble particles, and the pore connectivity is not ideal. When the porosity is high (such as more than 80%), the mechanical properties of the material become very poor Difference

[0004] In summary, the current international research on porous bioactive ceramics is still unable to achieve the combination of high porosity, suitable pore size, good connectivity, high mechanical strength, continuous molding, high production efficiency, and good controllability.

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