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Preparation method of copper-bearing compound coating on metal component of medical device and medical device

A technology for medical devices and metal parts, which is applied in the field of composite coatings on metal implanted devices and its preparation, which can solve the problems of surrounding tissue inflammation, control the degree of endothelialization, and low degree of skinning, and achieve blood compatibility Good, the effect of inhibiting endothelialization, good toughness and ductility

Active Publication Date: 2013-04-10
LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main problems in the application of medical metal materials are: 1) the biocompatibility of materials is not good, which can easily cause blood coagulation or inflammatory reactions in surrounding tissues; 2) the degree of endothelialization on the surface of materials is low; 3) due to the physiological environment The corrosion of metal ions will cause the diffusion of metal ions to the surrounding tissues and the deterioration of the properties of implanted materials. The former may cause toxic side effects, while the latter often leads to material failure.
[0009] 1. The commonly used coatings on cardiovascular medical devices are mainly used to improve the blood compatibility of materials, and also promote endothelialization, but some metal implanted devices only expect good blood compatibility and do not promote it in the short term. Endothelialization, the above coatings are difficult to meet the requirements of the latter
[0010] 2. Preparation of continuous elemental copper film on the surface of titanium material can inhibit the growth of cells, but the elemental copper film itself is easy to cause hemolysis, which reduces the blood compatibility of the device, and the excessive copper ions dissolved in the blood may cause toxic side effects
[0011] 3. Plasma implantation of copper on metal medical devices can achieve antibacterial effect, but due to the limited injection dose and the inability to form a complete covering film on the surface, it cannot effectively inhibit cell growth
[0012] 4. Copper nitrides have been widely studied in electronics due to their good optical properties, but copper nitride coatings have not been used to solve the technical problem of inhibiting endothelialization on the surface of biological materials.
[0013] 5. Although the above-mentioned coatings have good mechanical properties, none of them can achieve good blood compatibility and control the degree of endothelialization at the same time. This technical problem has not been effectively solved so far

Method used

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  • Preparation method of copper-bearing compound coating on metal component of medical device and medical device
  • Preparation method of copper-bearing compound coating on metal component of medical device and medical device
  • Preparation method of copper-bearing compound coating on metal component of medical device and medical device

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A copper-titanium mixed coating is deposited on the surface of medical nickel-titanium alloy by plasma arc plating.

[0042] Step 1, the medical nickel-titanium alloy product is first cleaned. Before cleaning, it is preferable to polish the article to obtain better cleaning effect. After cleaning, it is preferable to dry the product and then store it in a dry dish for future use, so as to facilitate rapid mass production.

[0043] In step two, the nickel-titanium alloy products after step one are pretreated. An easy-to-implement pretreatment process is as follows: set up a vacuum system, put the nickel-titanium alloy product into the vacuum chamber, and make the vacuum chamber air pressure less than 3.0×10 -3 Pa, the argon gas flow rate is 30-50sccm (sccm: standard ml / min), so that the vacuum chamber pressure reaches 0.5Pa, and the bias voltage is applied to make the argon gas glow discharge, at this time, slowly adjust the bias power supply to 400-500V , so that arg...

Embodiment 2

[0048] A copper-titanium mixed coating is deposited on the surface of medical nickel-titanium alloy by plasma arc plating.

[0049] Step 1, the medical nickel-titanium alloy product is polished, cleaned and dried, and then stored in a desiccant for later use.

[0050] Step 2, take out the nickel-titanium alloy product in the drying dish, and pretreat it, the pretreatment process is as follows: set up a vacuum system, put the nickel-titanium alloy product into the vacuum chamber, so that the vacuum chamber air pressure is less than 3.0×10 -3 Pa, the argon gas flow rate is 30-50sccm (sccm: standard ml / min), so that the vacuum chamber pressure reaches 0.5Pa, and the bias voltage is applied to make the argon gas glow discharge, at this time, slowly adjust the bias power supply to 400-500V , so that argon ions are sputtered to clean the surface of the nickel-titanium alloy product, and the cleaning time is 5-10 minutes.

[0051] Step 3, prepare to start the cathode target in the v...

Embodiment 3

[0055] Step 1, the medical nickel-titanium alloy product is polished, cleaned and dried, and then stored in a desiccant for later use.

[0056] Step 2, take out the nickel-titanium alloy product in the drying dish, and pretreat it, the pretreatment process is as follows: set up a vacuum system, put the nickel-titanium alloy product into the vacuum chamber, so that the vacuum chamber air pressure is less than 3.0×10 -3 Pa, the argon gas flow rate is 30-50sccm (sccm: standard ml / min), so that the vacuum chamber pressure reaches 0.5Pa, and the bias voltage is applied to make the argon gas glow discharge, at this time, slowly adjust the bias power supply to 400-500V , so that argon ions are sputtered to clean the surface of the nickel-titanium alloy product, and the cleaning time is 5-10 minutes.

[0057] Step 3, prepare to start the cathode target in the vacuum chamber, the cathode target is titanium target (Ti 99.99%) and copper target (Cu 99.99%); stop feeding argon into the va...

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Abstract

The invention relates to a copper-bearing compound coating on a metal component of a medical device and a preparation method thereof. The preparation method comprises the following steps of step one, washing the surface of the metal component of the medical device; step two, putting the metal component of the medical device into a vacuum chamber and performing pretreatment on the metal component; and step three, generating copper ions in the vacuum chamber, causing the copper ions to move towards the surface of the metal component of the medical device under the action of bias for combination with ions of another element in the vacuum chamber, and reacting on the surface of the metal component of the medical device for the formation of the copper-bearing compound coating. The copper-bearing compound coating on the metal component of the medical device provided by the invention not only is good in blood compatibility, but also can prevent the cells from growing on the device surface for the realization of inhibition on the material surface endothelialization; and additionally, the invention also relates to the medical device.

Description

technical field [0001] The invention relates to a medical device and a preparation method thereof, in particular to a composite coating on a metal implant device in contact with blood and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the primary reasons that threaten human health and life at present. Medical device interventional therapy is a convenient and effective treatment method, which has the characteristics of less trauma, faster recovery and less side effects. Cardiovascular implant devices that have been widely used include vascular stents, heart valve rings, venous thrombosis filters, embolic devices, etc. Most of these medical devices are designed and processed with biomedical metal materials. At present, such biomedical metal materials include medical stainless steel, cobalt-based alloys, titanium and titanium alloys, absorbable metal materials, nickel-titanium shape memory alloys, tantalum, niobium, gold and silver ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/32C23C14/16
CPCA61B2017/00889A61B2018/00148C23C14/48C23C30/00
Inventor 刘恒全张德元
Owner LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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