Single-composition traditional Chinese medicine preparation, and preparation method and application thereof

A technology for the preparation of traditional Chinese medicine preparations and strains, which is applied in the direction of drug combinations, urinary system diseases, fungi, etc., can solve the problems of scarcity of natural cicadae resources, long production cycle, and unstable quality, so as to reduce the proliferation of mesangial cells, Improvement of renal function, safety and side effects

Active Publication Date: 2011-11-16
ZHEJIANG BIOASIA PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, studies have found that the natural medicinal fungus cicadae can reduce the synthesis of extracellular matrix, delay glomerular sclerosis, and improve kidney function. low problem
The researchers found that the artificial culture of cicadae not only has similar components and efficacy with natural cicadae, especially in the treatment of chronic renal failure, it also has the ability to reduce serum creatinine and urea nitrogen levels, improve kidney function, and inhibit mesangial cell proliferation and matrix increase, delay the progress of glomerular sclerosis, and also solve the problems of natural cicadae's resource scarcity, low yield, unstable quality, etc.

Method used

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  • Single-composition traditional Chinese medicine preparation, and preparation method and application thereof
  • Single-composition traditional Chinese medicine preparation, and preparation method and application thereof
  • Single-composition traditional Chinese medicine preparation, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The artificial cultivation of embodiment 1 unilateral Chinese medicine preparation

[0056] Pick Paecilomyces cicadae strains and insert them into PSA culture medium, cultivate them for 3-5 days under the conditions of 22°C-25°C and 140rpm for later use; put the seeds into the solid medium according to the ratio of 3-5%, and put them into solid medium at 20°C-25°C. Cultivate at 60%-80% relative air humidity for 30d-50d. Lighting is required in the later growth stage of spore bundles, and the temperature is slightly lower than the mycelium growth stage by 2°C. Open windows every day to keep the air in the cultivation room Fresh.

[0057] The ratio of the PSA medium used in this embodiment is per 1000ml medium: 200g of potatoes, 20g of sucrose, and 20g of agar.

[0058] The proportion of the solid medium in this embodiment is 46 parts by weight of substrate, 5 parts by weight of bagasse, 0.4 parts by weight of shell powder, 2.5 parts by weight of silkworm chrysalis powde...

Embodiment 2

[0059] One of the preparation methods of embodiment 2 unilateral Chinese medicine preparation

[0060] The harvested fresh cicada artificial culture is dried at 70°C for 10 hours, pulverized by a pulverizer, and passed through a 120-mesh sieve to obtain dry powder.

Embodiment 3

[0061] The second of the preparation method of embodiment 3 unilateral Chinese medicine preparation

[0062] Add water to the artificially cultivated Cicada japonica and decoct twice for 0.5 hours each time. The decoction is vacuum filtered to remove impurities to obtain a filtrate, which is concentrated to an appropriate amount by a vacuum film and spray-dried to obtain a dry powder.

[0063] The single Chinese medicine preparation of embodiment 4 embodiment 2 is to the renal function influence of 5 / 6 nephrectomy rat model

[0064] The data of this example are quoted from: Zhu Rong, Chen Yiping, Deng Yueyi, Wang Lin. Experimental research on the effect and mechanism of delaying glomerulosclerosis of cicadae hyphae by solid culture, Chinese Journal of Integrative Medicine and Nephrology, 2005, 6(2): 70-74

[0065] Test substance:

[0066] The unilateral Chinese medicine preparation of embodiment 2.

[0067] Positive control drug: Kesuya, produced by Hangzhou Merck Pharmaceu...

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Abstract

The invention provides a single-composition traditional Chinese medicine preparation, and a preparation method and application thereof. The traditional Chinese medicine preparation is characterized by being prepared from a main raw material of an artificially cultivated cicada active component. The single-composition traditional Chinese medicine preparation provided by the invention has obvious treatment and prevention effects on generation and development of chronic renal failure. According to animal experiments, the single-composition traditional Chinese medicine preparation provided by the invention can improve kidney functions, lower serum creatinine level and urea nitrogen level, increase hemoglobin, reduce ECM (extracellular matrix) deposition, mitigate renal tubulointerstitial injury and delay renal interstitial fibrosis; besides the single composition is safe, effective and without obvious toxic or side effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and specifically relates to a single Chinese medicine preparation for preventing and treating chronic renal failure and other chronic kidney diseases, a preparation method and application thereof. Background technique [0002] Chronic renal failure (CRF) is a syndrome composed of chronic renal dysfunction caused by chronic kidney disease and systemic diseases involving the kidney, as well as various clinical symptoms and metabolic disorders arising therefrom. CRF is a difficult disease that seriously endangers the health of patients and even threatens their lives. A large number of clinical and experimental studies have confirmed that after chronic kidney disease of different etiologies has suffered a certain degree of damage to the kidney, although the underlying disease has stopped, the renal function will continue to decline. Therefore, how to prevent...

Claims

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Application Information

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IPC IPC(8): A61K35/64C12N1/14A61P13/12
Inventor 陈以平陈祝安柏乃庆孙长胜朱戎盖悦赵伟李成
Owner ZHEJIANG BIOASIA PHARMA CO LTD
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