Hemokinin-iron oral liquid

Abstract

The invention provides a divalent hemokinin-iron oral liquid, the preparation method thereof comprises: separating hematid out of blood of livestock or poultry, adding doubleness distilled water, combining ultrasonication to break wall, releasing hemoglobin, adjusting pH value of hemoglobin solution, adding protease, placing in a vacuum dry chamber, leading in pulse current for acting for 4 hours,carrying out heating enzyme killing treatment at 95 DEG C for 30 minutes, obtaining divalent hemokinin-iron with purity more than 90% by metal-chelating affinity chromatography and electromagnetic separation, then adding tomato juice, red date juice, liquorice juice, angelica sinensis juice, astragalus mongholicus juice, juice of dried rhizome of rehmannia, stevioside, glycoprotein, carrageenan and algae ester sodium to blend so as to obtain the hemokinin-iron oral liquid. The oral liquid beverage product prepared by the invention has small dose, good mouth feel and high portability, can be directly absorbed by intestinal mucosal cells, cannot directly generate any digestion characteristic irritation symptom, and the absorptivity is high.

Description

technical field [0001] The present invention relates to a biological product and its preparation method, in particular, it provides a preparation method of divalent heme peptide-iron and its separation and purification method. The fields of application are iron supplement capsules, iron supplement granules, iron supplement oral liquids or iron supplement beverages. Background technique [0002] Iron is an indispensable nutrient in the vast majority of organisms. It contains about 4-5 grams in the adult body, accounting for only 1 / 10,000 of the body weight. present in the form of ferritin (23%). But its role is very important. Iron is the basic raw material for the body to produce hemoglobin, myoglobin and iron-containing enzymes. It is an essential trace element for the human body. It participates in the transportation of oxygen and carbon dioxide in the body and is a component of tissue respiratory enzymes such as cytochrome oxidase and peroxidase. . Therefore, the impo...

AI Technical Summary

Problems solved by technology

Treat IDA, adopt iron therapy more at home and abroad, although these products have certain curative effect, there are following problems: (1) low bioavailability: just be difficult to be absorbed by human body as the ferrous sulfate that has been popular for more than 200 years, the absorption rate About 1.6%, other inorganic iron and organic iron, the absorption rate is also between 3% and 5%

(2) Large side effects: These iron products all destroy the balance of metal ions in the human body and cause adverse reactions in the gastrointestinal tract. In order to reduce the side effects of gastrointestinal discomfort, they are required to be taken after meals. Inhibits iron absorption, making its absorption rate even lower

(3) Poor taste, difficult to adhere to: These products often have a certain rusty taste, and the taste is not good. In addition, the treatment of IDA often requires several months (2-6 months) of treatment, which is even more difficult to adhere to

The process is relatively complicated, the yield is not too high due to the loss of active ingredients, a large amount of chemical reagents are consumed, the cost is high, and the extracted hemoglobin is extremely unstable

In addition, the use of pyridine-based mixed solvents to extract hemoglobin has certain toxicity and odor, pollutes the environment, and endangers health.

Therefore, its application is limited

Chinese patent CN1362525 discloses a method for preparing small peptide heme by ultrafiltration and enzymatic hydrolysis. Although this method requires less introduction of chemical reagents, the whole process is too cumbersome (12 steps), and the heme is lost during the ultrafiltration process. Too much, the cost of the added enzyme preparation is too high, so it still cannot meet the application requirements

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