Skin externally-applied liquid state and solid state kreotoxin (liushengtai) composite nano emulsion and preparation thereof

Abstract

The present invention relates to external liquid and solid kreotoxin (argireline) composite nanometer latex for skin and a preparation method thereof. The weight proportion of each raw material of liquid nanometer latex is 10g of isopropyl myristate, 2g of vitamin E, 0.8g of vitelline lecithin, 0.2g of ginseng saponin, 0.01g of rhodiola element, 0.005g of the argireline, 0.001g of superoxide dismutase, 0.5g of reduction type glutathione, 5g of fetal calf serum, 0.05g of hyaluronic acid, 0.05g of ceramide, 40g of distilled water, 36g of polyethylene glyceride glycol caprylic decanoate and 12g of polyglycerol fatty acid ester; the weight proportion of each raw material of solid nanometer latex is 10g of the isopropyl myristate, 2g of the vitamin E, 0.8g of the vitelline lecithin, 0.2g of the ginseng saponin, 0.01g of the rhodiola element, 0.005g of the argireline, 0.001g of the superoxide dismutase, 0.5g of the reduction type glutathione, 5g of the fetal calf serum, 0.05g of the hyaluronic acid, 0.05g of the ceramide, 40g of the distilled water, 36g of the polyethylene glyceride glycol caprylic decanoate, 12g of the polyglycerol fatty acid ester, 22g of mannitol and 3g of glycin.

Description

technical field [0001] The invention relates to biological skin beauty and health care preparation products and technologies, in particular to a liquid and solid botulinum toxin (hexapeptide) composite nanoemulsion for skin external use and a preparation method thereof which can be used for delaying skin aging and beautifying and anti-wrinkle. Background technique [0002] Background technology about skin wrinkles: [0003] The skin is located on the surface of the human body and is generally composed of the epidermis, dermis and subcutaneous fat tissue. It is the largest organ of the human body and is responsible for important physiological functions. The skin not only has a very important barrier function and defense function, but also has many physiological and metabolic functions. However, with the passage of time and the growth of age, human skin, like other tissues and organs, gradually begins to age. Skin aging is an unchangeable natural law. One of the most intuiti...

AI Technical Summary

Problems solved by technology

[0050] ②Because botulinum toxin is an invasive beauty treatment method, which has certain risks, and multi-point injection at multiple sites is more painful. Therefore, the use of type A botulinum toxin for skin beauty is not a general cosmetic behavior (or industry behavior) , but a kind of medical behavior, and it is a high-level medical behavior. It cannot be carried out in general beauty salons. Both individuals and individuals must be certified, and only units and individuals that meet the above conditions can supply and use medicines

[0052] ④Local injection of botulinum toxin type A is ideal for forehead wrinkle removal, followed by crow's feet and dorsum lines, but less effective for brow lines

Hexapeptide has the effect of botulinum toxin, but without the side effects of botulinum toxin for injection

[0066] In summary, any of the above-mentioned skin anti-wrinkle methods has one or another problem: such as taking preventive measures (including balanced diet, moderate exercise, maintaining a good attitude, etc.), it can only play a certain role in the generation of skin wrinkles. preventive effect, but cannot achieve the effect of reducing or eliminating skin wrinkles

Moreover, due to the large molecular weight of type A botulinum toxin (greater than 150,000 Daltons), it is difficult to apply it externally on the skin, or to exert its dominant effect through the skin action pathway; , or accidentally entering the eyes during external use on the skin will have more serious effects and consequences

It can be seen that the use of botulinum toxin injection therapy for wrinkle removal has certain risks and many limitations. It is difficult to absorb and maintain the activity of botulinum toxin when it is formulated into external skin preparations, and it cannot exert its proper skin, muscle and nerve paralysis. To achieve the effect of skin muscle relaxation and beauty anti-wrinkle

[0072] Although there are many types and effects of peptides, and many developed countries such as Europe, America, Japan and South Korea, as well as Hong Kong, Macao and Taiwan have been used in high-end beauty cosmetics, especially hexapeptide is used as a substitute for botulinum toxin for skin beauty. and anti-wrinkle, but there are still some defects and problems in the application, such as peptides (including hexapeptide) are water-soluble, although the molecular weight is very small, it is still difficult to exert its due biological effects through the skin, even if With the assistance of some penetration enhancers that can promote its transdermal absorption, its effect still cannot reach the theoretical effect. Clinical trials show that the anti-wrinkle response is relatively slow, and the curative effect is still not very significant; The anti-wrinkle effect is achieved through the inhibition of facial muscle nerve transmission similar to botulinum toxin and the paralysis of the facial nerve. Therefore, the facial expression still looks a little unnatural and uncoordinated, especially if the simple use of hexapeptide, which is similar to botulinum toxin However, its anti-wrinkle effect is still only effective for some wrinkles caused by facial expression muscle movement, but has no substantial improvement and curative effect on wrinkles caused by physiological aging and photoaging. Moreover, it is effective for those wrinkles caused by facial expression muscle movement. The effect of the resulting wrinkles is only very short-lived and reversible, and cannot fundamentally solve the problem of skin wrinkles