Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of targeted oxidative therapeutic formulation in treatment of cancer

A technology of oxidizing agents and cancer, applied in the field of pharmaceutical compositions or preparations to treat cancer, and can solve problems such as preparation or storage hazards

Inactive Publication Date: 2007-12-05
罗伯特·F·霍夫曼
View PDF10 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, their preparation or storage is extremely dangerous

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of targeted oxidative therapeutic formulation in treatment of cancer
  • Use of targeted oxidative therapeutic formulation in treatment of cancer
  • Use of targeted oxidative therapeutic formulation in treatment of cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1. The ozonolysis of unsaturated hydrocarbon

[0085] Ozonolysis of alkenes can be performed in solution or neat. In either case, cooling of the reaction mixture is critical to prevent explosive decomposition of the peroxidized product of the reaction.

[0086] The following general procedure is typical for the ozonolysis of liquid alkenes.

[0087] The alkene (2 moles) was charged to a 1 liter flask with a magnetic stirrer bar and the apparatus was weighed. Surround the flask with a cooling bath (ice-water or ice-salt). Once the contents have cooled below 5°C, agitation is started and a stream of ozone-containing dry oxygen (typically 3% ozone) is passed through the mixture. Dispersing the ozonated oxygen by means of a glass frit is advantageous, but not necessary for stirred solutions. Periodically stop gas flow and weigh the reaction flask or sample the reaction mixture. Then restart the airflow.

[0088] Once the mass of the reaction flask shows suffi...

Embodiment 2

[0091] The preparation of embodiment 2 pharmaceutical preparations

[0092] A preferred pharmaceutical formulation of the invention is prepared as follows:

[0093] (1) Bubble 120mg / L of ozone / pure oxygen gas mixture upward through a kind of alkadiene alcohol-3,7-dimethyl-2,6-octadiene- 1-alcohol (geraniol);

[0094] (2) keep the temperature of the reaction at about 5°C;

[0095] (3) Take out the reaction product of small aliquot every hour, and use H 1 NMR measures the formation of peroxide species or reaction products;

[0096] (4) Stopping the reaction when more than 50% of the available unsaturated bonds have reacted;

[0097] (5) Dilute the product mixture with dimethyl sulfoxide (1:10) to obtain a solution or dispersion;

[0098] (6) Before use in the target biological system, add the mixture of hematoporphyrin, rose bengal and menaquinone dry powder to the solution or dispersion in an amount sufficient to allow each component dispersed therein to pass through the s...

Embodiment 3

[0099] The example of embodiment 3 pharmaceutical preparations

[0100] Two preferred formulations are as follows:

[0101] weight%

[0102] *Determined by mass spectrometry

[0103] weight%

[0104] *Determined by mass spectrometry

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, Su has ozone; a penetrating solvent, such as dimethylsulfoxide (''DMSO''); a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone. The pharmaceutical formulation is used to effectively treat patients affected with cancer, such as lymphoma.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 60 / 569,595, filed May 10, 2004, entitled "Use of Targeted Oxidative Therapeutic Formulation in Treatment of Cancer," which is hereby incorporated by reference in its entirety . technical field [0003] The present invention relates to compositions comprising peroxidic species or oxidation products, processes for their preparation, and their use. More specifically, the present invention relates to pharmaceutical compositions or formulations comprising: peroxide species or reaction products produced by the oxidation of alkenes by oxygen-containing oxidizing agents, in liquid form or in solution; containing chelated Metallic dyes; and aromatic redox compounds. The invention also relates to the preparation of said pharmaceutical preparation and its use for the treatment of cancer. Background technique [0004] Ozone is a triatomic gas molecule and an allotrop...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K31/327A61K31/045A61K33/40A61P35/00A61K31/12A61K31/409A61K31/525A61K31/555A61K33/24A61K33/26A61K45/06
CPCA61K31/525A61K9/0019A61K33/26A61K31/12A61K31/01A61K31/327A61K33/40A61K33/24A61K31/555A61K31/045A61K45/06A61K31/409A61P35/00A61K2300/00
Inventor 罗伯特·F·霍夫曼
Owner 罗伯特·F·霍夫曼
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com