Centella soft capsule and its preparing method

Abstract

The present invention relates to a Chinese medicine centella asiatica soft capsule and its preparation method. It is basically formed from capsulation solution and capsule material. Said capsulation solution includes centella asiatica extract, emulsifying agent, emulsification adjuvant, vegetable oil and natural perfume compound, and the capsule material is composed of gelatin, glycerine, polyethylene glycol, water, coloring agent and corrective. Said soft capsule can be taken orally, also can be used for external application.

Description

technical field [0001] The invention relates to a centella asiatica soft capsule made of centella asiatica extract, which can be administered orally or locally; the invention also relates to a preparation method of the soft capsule. Background technique [0002] Centella asiatica (Centella asiatica L.Urban.) has a long history of medicinal use in China. It was first recorded in "Shen Nong's Materia Medica". The dry whole herb of Centella asiatica of the genus Centella asiatica; the medicine is cold in nature and bitter in taste, enters the spleen meridian, and its effects are promoting blood circulation, reducing swelling and pain, and has the functions of clearing away heat, detoxification, and diuresis; folks often use it to treat various types of diarrhea Common heat-toxin diseases such as wounds, hot boils, boils, red eyes and hot eyes, sore throat, etc. [0003] Centella asiatica contains a large amount of triterpenoid saponins, such as: asiaticoside, madecassoside, br...

AI Technical Summary

Problems solved by technology

[0009] Ointments, gels and other topical preparations for external use can be used as the dosage form of active ingredients that only need to exert their medicinal effects locally, and are also accepted by patients who cannot accept oral and injection administration, unless quantitative administration is not required, otherwise There is a defect that the dosage cannot be accurately fixed, so that such preparations often show good effects in experimental studies, and once patients use them independently, they often cannot stably achieve their due drug effects

[0010] Ordinary soft capsules containing active ingredients in the encapsulation solution are generally oily homogeneous solutions such as vitamin AD, vitamin E and other products or suspensions, such as topical administration, low adhesion and easy to disperse and lose, resulting in dosage Inaccurate, or unable to be fully effective, unless there is no external dosage form and clinical needs, it is generally not used as a topical drug product

Some external soft capsules that have been on the market cannot be taken orally, such as chloramphenicol ear capsules, vaginal soft capsules, etc.

[0011] Except for volatile oils, the active ingredients in ordinary traditional Chinese medicine soft capsules exist in the form of extracts. Before making soft capsules, they are dried into dry extracts and then fed. When the water content exceeds 5%, the possibility of swelling, rupture and oil leakage of the soft capsules during storage increases greatly. Therefore, when producing soft capsules made of traditional Chinese medicine extracts, the moisture content of the dry extract must be strictly controlled, resulting in The production energy consumption increases and the cost increases; and the dry extract exists in the form of suspended particles in the oily liquid medicine, and the stability is not high, and the soft capsules made from this will appear delamination and stick to the wall during storage.

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