The invention belongs to the technical field of laboratory management and monitoring, and particularly relates to an all-weather window laboratory instrument management system and method. The system comprises an instrument management service unit, a plurality of information display units, a plurality of window control units, a plurality of instrument control units and a plurality of user query units. The invention discloses the laboratory instrument management method. The method comprises the steps that first, a borrower accesses the instrument management service unit of a laboratory to perform account registration, query and reservation operations, and then, the borrower goes to a window within a defined reservation time to be subjected to identity verification and to confirm borrowing of instruments; after the instruments are used, the borrower opens the window through the identity verification at the window and confirms return; and finally, after the return succeeds, expenses are deducted from an account of the borrower, thereby realizing a borrowing service. According to the system and the method, the management is convenient, the difficult problem in all-weather watching of the open laboratory is effectively solved, the resource advantages of the laboratory can be brought into full play, and the utilization efficiency and economic benefits of laboratory instruments are improved.