31results about How to "Efficient and cost-effective production" patented technology

Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.

A method for the automatic correction of alignment errors in individual star trackers (R, S) of star tracker systems (1) is provided. The correction of orientation errors is necessary whenever it is not possible to mount the star trackers of the star tracker system on a shared stable block of a platform. Orientation errors can arise due to installation deviations and deformation of the platform, for instance, caused by mechanical loads or temperature fluctuations. A star tracker (R) that is attached in a very stable manner to the platform serves as the reference tracker. The orientation that it measures constitutes the reference information. An error signal and an orientation matrix are derived from the measured orientation of the other star trackers, thereby effectuating the correction of the coordinate systems of the star trackers that are to be corrected, and thus of their measured quantities. The resulting orientation as the starting quantity of the star tracker system is then calculated on the basis of the orientation information of the reference tracker and of the other star trackers. The linking of the measured results of the individual star trackers can take place on the level of the star vectors of a star catalog, on the level of preprocessed tracker signals or on the level of the quaternions and/or on the level Euler angles.

A seal and corresponding method of manufacture of stacks enabled by the physical properties of the seal are provided. In the instance of a fuel cell or other electrochemical stack, the seal provides low-cost manufacturing and reliable/durable operation in high temperature (e.g., 120° C. to 250° C.) and acidic environments. The seal provides an elastomeric material characteristic providing resiliency and flexibility, and a protective characteristic that protects the seal from the high temperature acidic environment, such as found in high temperature PEM fuel cells. The seal is affixed to a plate of a fuel cell stack assembly prior to assembly of the stack, such that there is no requirement to apply an adhesive seal, gasket, free flow to solid sealing material, or the like, to each plate during assembly of the fuel cell stack, or during a disassembly and re-assembly process.

Electronic circuit arrangement, includes a chip and a chip carrier having a substrate and a chip contact location. At least the chip contact location is provided with a soldering layer. The chip includes a bonding layer. A silver layer for eutectic bonding with the bonding layer is provided on the soldering layer in the region of the chip contact location.

The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA.

The moulding tool is a near-net-shape negative mould for shaping a ceramic green body for the lens. The mould has a shaping surface, which is described by the following equation B:

y1 gives a position on an optical axis; x designates a perpendicular distance from the optical axis to the surface; k, c, and a₁, a₂, a₃, a₄, . . . are constants describing a surface of the lens to be moulded and z=|x|+b, wherein b is a constant with a value greater than 0 and less than 0.3 mm, which is a measure of a deviation of the shaping surface from the surface of the lens.

The invention relates to the field of cell culture technology. It concerns the knockdown, using RNA interference, or gene knockout, of activating transcription factor 6 beta (ATF6B), or the combination of ceramide synthase 2 (CERS2) and TBC1 domain family member 20 (TBC1 D20) proteins, which play central roles in the cellular secretion pathway. This downregulation leads to improved secretion of biopharmaceutically relevant products produced in mammalian cells. The invention specifically relates to mammalian cells having enhanced secretion of a recombinant therapeutic protein compared to a control cell, a method of producing said mammalian cell, a method for the production of a recombinant secreted therapeutic protein and the use of said mammalian cell for increasing the yield of a recombinant secreted therapeutic protein.