The invention provides a cloth spreading machine with a manipulator cloth clamping mechanism. The cloth spreading machine comprises a making bed, a main machine, a cloth pressing mechanism above the making bed, and the manipulator cloth clamping mechanism arranged on the making bed in a sliding mode. The main machine is provided with a cloth making mechanism, a cloth releasing mechanism is arranged on one side of the cloth making mechanism, a cloth spreading mechanism is arranged on the other side of the cloth making mechanism, a front-positioning cloth spreading mechanism is arranged in front of the cloth spreading mechanism, a cloth feeding mechanism is arranged in front of the front-positioning cloth spreading mechanism, and a cloth cutting device is arranged below the cloth feeding mechanism; cloth materials enter from the cloth releasing mechanism to the cloth cutting device through the cloth spreading mechanism, the front-positioning cloth spreading mechanism and the cloth feeding mechanism, and the manipulator cloth clamping mechanism arranged on the making bed in the sliding mode is matched with the cloth cutting device to cut off cloth materials with setting lengths. The cloth spreading machine has the advantages that the manipulator cloth clamping mechanism is adopted to carry out single-pulling cloth folding, positioning is accurate, precision is high, the cloth is tidily folded, neatness of the two ends of the cloth can be effectively controlled, accuracy of cloth cutting is improved, and working efficiency is high.