The invention provides novel materials for chromatography and chromatography columns. The invention provides a monofunctional silane chemically bonded to a substrate, the monofunctional silane has two groups, R, and R′, the monofunctional silane being of the form: where the R groups are independently selected from the group consisting of alkenyl, alkynyl, and phenyl, R′ is selected form the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, alkylamine, amide, ether, alcohol, cabamate, ester, an anion exchanger, and a cation exchange. Methods for manufacture and design of the columns are also provided and disclosed.