The invention relates to a voice noise reduction method and device, equipment and a storage medium. The method comprises the steps of obtaining a to-be-denoised spectrogram corresponding to a to-be-denoised voice; inputting the to-be-denoised spectrogram into a preset voice noise reduction model to be subjected to noise reduction processing, and acquiring a noise-reduced spectrogram, wherein the voice noise reduction model sequentially comprises a coding module, a frequency domain noise reduction module, a time domain noise reduction module, a decoding module and a mask enhancement and suppression module; and performing voice signal reconstruction on the frequency spectrogram after noise reduction to obtain a target voice. According to the invention, feature extraction, frequency domain noise reduction, time domain noise reduction, decoding and mask enhancement and suppression are performed in sequence by adopting the voice noise reduction model, effective noise reduction is realized by performing frequency domain noise reduction and time domain noise reduction in sequence, the noise reduction effect is improved, the accuracy of the obtained noise-reduced voice is improved, and the user experience is improved; and frequency domain noise reduction and time domain noise reduction are processed separately, decoupling of the time domain and the frequency domain is achieved, and streaming voice noise reduction is facilitated.