Pheretima injection preparation and its preparing method

Abstract

The present invention discloses an earthworm injection preparation and its preparation method. It is characterized by that the effective component can be extracted from earthworm, after the effective component is purified, the medicinal auxiliary material is added, then made into the invented earthworm injection preparation. Said invention adopts 6%-8% sodium chloride to treat earthworm and remove earthworm toxin, and utilizes physiological saline to soak the earthworm, and adopts the processes of filtration and ion exchange, etc. to obtain effective component of earthworm, then said effective component can be made into injection preparation.

Description

Technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an earthworm injection preparation and a preparation method thereof. Background technique [0002] Earth Dragon, Lumbrricus, this product is the dried body of Lumbricus or Lumbricus. The former is produced in Guangdong and Guangxi and is called "Guangdilong", while the latter is produced in Henan, Shandong and Jiangsu and is called "Dilong". Alias, earthworm, cricket, soil dragon, the main ingredients include Lum-brofebrine, Lumbrilin, Terrestro-Lumbroly-sin, amino acids, purines, choline, fatty acids, etc. , salty in nature, cold, returns to the liver, spleen, and lung meridian, the main function is to clear away heat, calm convulsions, relieve asthma, diuretic, have antipyretic, blood pressure, bronchial diastolic, and spasm-relieving effects, clinically used for: hypertension, bronchial Asthma, febrile convulsions, hemiplegia, hemiplegia, mumps, erysipelas, herp...

AI Technical Summary

Problems solved by technology

[0005] The patent application for "Preparation Method of Active Earthworm Dry Powder" announced by the Chinese Patent Office on April 12, 2000, discloses a method for preparing Earthworm freeze-dried powder. The method is to wash fresh and alive Earthworm Frozen into ice cubes, then dissolved in saline solution, and autolyzed and stirred to form a slurry. After the obtained homogenate was centrifuged at least once, the supernatant was pre-filtered, sterilized and concentrated by ultrafiltration to obtain a dry powder. The activity of the earthworm freeze-dried powder made by this method is relatively low; the patent "Preparation Method of Highly Active Lumbrokinase Dry Powder" whose application number is 02129969.2 adds sodium polyacrylate solution to purify in the preparation method, and the effective parts obtained are not processed. Activity detection, so the activity of its active ingredients needs to be deliberated; the patent document with application number 03146692 adopts the method of ultrafiltration, anion exchange, and gel filtration to prepare lumbrokinase, which is complicated to operate and has a large production cost in actual production; No. 02153848 patent document adopts the method of anion exchange and hydrophobic column chromatography to obtain 3 active components of earthworm. This method does not completely extract the active parts of earthworm, and industrialization has certain difficulties; the patent document with application number 02129969 uses What is more is that the method for salting out and ultrafiltration obtains lumbrokinase, and the lumbrokinase purity that this method obtains is not high, thereby causes activity is not high; Application number is that the patent document of 02116271 adopts affinity chromatography to obtain lumbrokinase, and this method is not suitable for industrialization Production; the patent document of application number 03146692 obtains lumbrokinase by the method for salting out, and the lumbrokinase purity that this method obtains is not high, activity is not good; This method obtains lumbrokinase purity is not high, activity is not good