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Method for extracting silibinin

A technology for silibinin and silymarin, which is applied in the field of extraction of medicines for treating liver diseases, can solve the problems of poor operability, low yield, poor product quality and the like, and achieves the effects of improving the total yield and reducing the cost.

Active Publication Date: 2011-05-25
JIANGSU TASLY DIYI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for extracting silybin from silymarin, which solves the problems of poor operability, low yield and poor product quality in the existing extraction method of silybin

Method used

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  • Method for extracting silibinin
  • Method for extracting silibinin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Add 300kg of 80% ethanol into the extraction pot, and add 50kg of silymarin under stirring. Heated and refluxed for 30 minutes. Open the bottom valve of the extraction pot, let the extract part enter the concentration pot, heat and concentrate, concentrate the ethanol and then enter the extraction pot, and concentrate and extract for 1.5 hours. Stop the extraction, filter the extraction pot extract, wash with 80% ethanol, and filter dry to obtain a yellow muddy precipitate, which is vacuum-dried at 80° C. for 6 hours to obtain crude silibinin, weighing 12.8 kg, and the yield is 25.6%.

[0050] Add 75kg of 95% ethanol and 12.5kg of crude silibinin in the extraction pot. Heated and refluxed for 30 minutes. Open the bottom valve of the extraction pot to allow the extract part to enter the concentration pot, and after concentration, the ethanol enters the extraction pot. Concentrate extraction cycle for 1 hour. Stop the extraction, filter the extraction pot extract, was...

Embodiment 2

[0053] Add 800kg of 70% ethanol into the extraction pot, and add 100kg of silymarin under stirring. Reflux for 30 minutes. Open the bottom valve of the extraction pot, let the extract part enter the concentration pot, heat and concentrate, concentrate the ethanol and then enter the extraction pot. Concentrated extraction cycle for 4 hours. Stop the extraction, filter the extraction pot extract, wash with 70% ethanol, and filter dry to obtain a yellow muddy precipitate, which is vacuum-dried at 80° C. for 10 hours to obtain crude silibinin weighing 26 kg with a yield of 26.0%.

[0054] Add 204kg of 95% ethanol and 25.5kg of crude silibinin into the extraction pot, stir and heat to reflux for 30 minutes. Open the bottom valve of the extraction pot to allow the extract part to enter the concentration pot, and after concentration, the ethanol enters the extraction pot. Concentrated extraction cycle for 4 hours. Stop the extraction, filter the extraction pot extract, wash with ...

Embodiment 3

[0057] Add 700kg of 75% ethanol into the extraction pot, and add 100kg of silymarin under stirring. Reflux for 30 minutes. Open the bottom valve of the extraction pot, let the extract part enter the concentration pot, heat and concentrate, concentrate the ethanol and then enter the extraction pot. Concentrated extraction cycle for 3 hours. Stop the extraction, filter the extraction pot extract, wash with 75% ethanol, filter and dry to obtain a yellow muddy precipitate, and vacuum-dry at 80° C. for 8 hours to obtain crude silibinin, weighing 26.4 kg; the yield is 26.4%.

[0058] Add 170kg of 95% ethanol and 25kg of crude silibinin into the extraction pot, stir and heat to reflux for 30 minutes. Open the bottom valve of the extraction pot to allow the extract part to enter the concentration pot, and after concentration, the ethanol enters the extraction pot. Concentrated extraction cycle for 2 hours. Stop the extraction, filter the extraction pot extract, wash with 95% ethan...

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Abstract

The invention discloses a method for extracting silybin, wherein silymarin is adopted as original raw material by the method, and undergoes two cycles of circumfluence, two cycles of condensation and extraction, decoloring and refining to produce the silybin. The method has the advantages of simple and convenient operative technology, obviously improved yield rate, decreased cost, and improved quality of products.

Description

technical field [0001] The invention relates to a method for extracting medicines for treating liver diseases, in particular to a method for extracting silybin from silymarin. Background technique [0002] Silibinin is a flavonoid compound isolated from the fruit of Silybum marianum, a plant of the genus Silybum in the family Asteraceae. As early as the 1st century AD, it has been recorded in Greek and Roman scriptures: milk thistle seeds contain new flavonoids, the main active ingredient is silibinin; silybin can protect liver cell membranes and improve liver function , Enhance the regeneration of liver cells, prevent liver damage caused by various liver poisons, and have good curative effect on acute and chronic hepatitis, liver cirrhosis and metabolic toxicity liver damage. Clinically used in patients with acute and chronic hepatitis, the symptoms, signs, and liver function have been significantly improved. It is reported in the literature that the extraction process of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04
Inventor 朱占元李斌王春建
Owner JIANGSU TASLY DIYI PHARMA CO LTD
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