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Medicinal composition of trichosanthes rind and its preparation method

The technology of Trichosanthes rind and composition is applied in the field of composition of Trichosanthes rind freeze-dried powder for injection and its preparation, which can solve the problems of high-temperature loss of active ingredients, poor stability, and inapplicability, and achieve the reduction of solids and stable Improved performance and good reproducibility

Inactive Publication Date: 2006-08-30
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the technical and cognitive level at that time, there were inevitably some defects, mainly in 1) the dosage form of the injection had to go through the sterilization process, and there was a problem of high temperature loss of active ingredients; 2) the injection was not easy to preserve, Transportation, some special conditions cannot be applied (such as extremely low temperature environment); 3) The stability is poor, and turbidity may occur after long-term storage
These all have a strong impact on the clinical application of Trichosanthes peel, and even produce clinical adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of Trichosanthes rind freeze-dried powder for injection

[0026] Take 5kg Trichosanthes rind and add water to decoct three times, 10 times the amount each time, for 2 hours for the first time, 1 hour for the second and third times, filter in stages, combine the filtrates and concentrate under reduced pressure to a relative density of 1.10-1.25 (30 ℃) (measured value 1.20), add 95% medicinal ethanol to make the alcohol content reach 70%, let it stand for 24 hours, take the supernatant, filter, reclaim ethanol, and pass through the pretreated 732 type cation exchange Resin, wash the resin with an appropriate amount of water for injection, then elute with 1mol / L ammonia solution, collect the eluate, remove the ammonia smell under reduced pressure, concentrate to a thick paste, and then vacuum-dry to obtain the Trichosanthes bark extract.

[0027] Fully dissolve the extract of Trichosanthes quinces in 500ml of water for injection, adjust the pH...

Embodiment 2

[0028] Embodiment 2: Preparation of Trichosanthes rind freeze-dried powder for injection

[0029] With reference to the method of embodiment 1, the prescription is:

[0030] Trichosanthes peel: 5000g

[0031] Mannitol: 40g

[0032] Make 1000ml, filling capacity 4ml.

Embodiment 3

[0033] Embodiment 3: the preparation of Trichosanthes rind freeze-dried powder for injection

[0034] With reference to the method of embodiment 1, the prescription is:

[0035] Trichosanthes peel: 5000g

[0036] Mannitol: 80g

[0037] Sodium bisulfite: 1g

[0038] Make 1000ml, filling capacity 4ml.

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Abstract

A freeze-dried powder injection for treating cardiovascular and cerebrovascular diseases is prepared from the extract of trichosanthes bark (5-100 Wt%) and the harmacologically acceptable auxiliary (0-5 Wt%). Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a medicinal composition of Trichosanthes peel, in particular to a composition of Trichosanthes peel freeze-dried powder for injection and a preparation method thereof. Background technique: [0002] Trichosanthes kirilowii Maxim. or Trichos-anthes rosthornii Harms is the dry mature peel of Cucurbitaceae plant Trichosanthes kirilowii Maxim. Pick the ripe fruit in autumn, cut it open, remove the pulp and seeds, and dry it in the shade. It is mostly produced in Hunan, Hubei, Guizhou, Sichuan and other places. Trichosanthes contains triterpenoid saponins, organic acids, resins, sugars, pigments, etc., and the seeds contain fatty oil. Traditional medicine believes that the skin of Gualoupa is sweet, slightly bitter, and cold, and enters the lung, stomach and large intestine meridian. It has the effects of widening the chest and dispelling stagnation, moistening the lungs and eliminating phlegm, and smoothing the intestines. Trad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/428A61K9/19A61P9/10A61K131/00
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司
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