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Use of isomalt (mixture of 1,6 GPS and 1,1 GPM) as a prebiotic for the production of a medicament used for the treatment of intestinal diseases, among other things

A 6-GPS, mixture technology, applied in the application, drug combination, confectionery and other directions, can solve the problem of low butyric acidity, etc., and achieve the effect of good technical processing

Inactive Publication Date: 2006-07-12
SUDZUCKER AG MANNHEIM OCHSENFURT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another disadvantage of known prebiotics is their relatively rapid fermentation and / or lead to the formation of only small amounts of butyric acid and thus only low butyrogenicity

Method used

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  • Use of isomalt (mixture of 1,6 GPS and 1,1 GPM) as a prebiotic for the production of a medicament used for the treatment of intestinal diseases, among other things
  • Use of isomalt (mixture of 1,6 GPS and 1,1 GPM) as a prebiotic for the production of a medicament used for the treatment of intestinal diseases, among other things
  • Use of isomalt (mixture of 1,6 GPS and 1,1 GPM) as a prebiotic for the production of a medicament used for the treatment of intestinal diseases, among other things

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: Effects of Isomalt on Humans

[0054] In order to detect the fermentation-promoting effect of isomalt on the intestinal environment in human body and the effect of taking isomalt on human intestinal microbial flora, 20 healthy subjects were treated in a double-blind, placebo-controlled crossover scheme. A group composed of test subjects conducts a cognitive intervention study. For this purpose, each subject received 30 g per day of isomalt as active substance or sucrose as placebo in each case during two 4-week test periods. The subjects received a standard basal diet during the two test periods. The test substance was taken several times a day in the form of baked goods, jams, chocolate, and other foods. The subjects received either 30 grams of isomalt or 30 grams of placebo by ingesting food from two planned diets that varied daily. The influence of other dietary factors could be ruled out by having the same basic diet in both test periods.

[0055] ...

Embodiment 2

[0074] Example 2: Effect of isomalt on microbial enzyme β-glucosidase activity

[0075] As part of the intervention study described in Example 1, in order to examine the effect of isomalt on the intestinal environment and its effect on the intestinal microflora and its activity in humans, at the end of two 4-week test periods Microbial β-glucosidase activity in fecal samples. Detection of β-glucosidase in stool samples by detecting the release of p-nitrophenol from the cleavage of p-nitrophenyl β-D-glucopyranoside. The reaction mixture containing 1500 μl of buffer, 400 μl of substrate (0.01 mol / L) and stool sample was incubated at 37°C for 1 hour, and after 60 minutes, 1 ml of terminator (0.1 mol / L glycine buffer, pH 12.0 ) and the resulting yellow intensity was measured spectrophotometrically at 405 nm. This intensity is directly proportional to the enzyme activity. The activity of the enzyme is expressed in terms of product [micromole] released per unit time [hour] per un...

Embodiment 3

[0078] Example 3: Degradation of Bifidobacteria to Isomalt

[0079] In vitro studies were performed using pure cultures of Bifidobacteria

[0080] To study the growth of Bifidobacterium human, various strains of Bifidobacterium human were initially grown in the following media (see below):

[0081] Casein peptone 10g

[0082] Meat Extract 5g

[0083] Yeast Extract 5g

[0084] Na 2 HPO 4 1.44 grams

[0085] NaH 2 PO 4 0.24 grams

[0086] K 2 HPO 4 6.0 grams

[0087] Tween 80 1.0 g

[0088] Cysteine / HCl 0.5g

[0089] DSM Medium 141 9ml

[0090] Vitamin solution in DSM medium 141 0.5 ml

[0091] Resazurin 1mg

[0092] Glucose 10 grams

[0093] Add water to make up to 1000ml, pH 7.0

[0094] Each strain contained 80% / 20% N in Hungate test tube 2 / CO 2 Incubate at 37°C for 48 hours under anaerobic conditions in air and then transfer again to the same nutrient medium. The cultures were then transferred to...

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Abstract

The invention relates to a novel use of a mixture of 6-O-alpha-D-glucopyranosyl-D-sorbitol and 1-O-alpha-D-glucopyranosyl-D-mannitol as a bifidogenic prebiotic optionally containing a probiotic, to be used as or for producing a food item, semi-luxury food, fodder, or a medicament. Said medicament is used for the treatment and / or prevention of intestinal diseases such as chronic inflammatory intestinal diseases, intestinal cancer, bacterial intestinal infections, among other things.

Description

technical field [0001] The present invention relates to the combination of 6-O-α-D-glucopyranose-D-sorbitol (1,6-GPS) and 1-O-α-D-glucopyranose-D-mannitol (1,1 - GPM) for use as prebiotics and / or butyrate donors, especially in relation to use as digestible carbohydrates beneficial to gut health in human food and other consumer products, animal feed products and / or pharmaceuticals . Background technique [0002] Human food and other consumer goods and animal feed products are primarily used for human or animal nutrition and survival. In addition to these two aspects, there is an increasing demand for human food and other consumer products to have a health-promoting effect. Food and other articles for human consumption should, on the one hand, preserve and promote health, and on the other hand, resist harmful influences and, where appropriate, prevent disease. Such nutraceuticals and other consumer products are expected to exert their effects primarily in the digestive trac...

Claims

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Application Information

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IPC IPC(8): A23L1/236A61K31/7016A61P1/00A23G3/34A23G9/52A23L1/30A23L2/02A23L2/52A23L27/30
CPCA23L1/2364A23L2/52A23L2/02A23L1/30A23G9/52A23G2200/02A61K31/7016A23G3/346A23L27/34A23L33/10A61P1/00A61K2300/00A23L27/30
Inventor 米夏埃尔·克林格贝格贡希尔德·科齐诺斯基马克瓦特·孔茨斯特凡·泰斯
Owner SUDZUCKER AG MANNHEIM OCHSENFURT
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