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Nano zirconium oxide tough-ened high porosity calcium phosphate artificial bone rack and its preparing method

A nano-zirconia, high-porosity technology, used in medical science, prosthesis, etc., can solve the problem of high porosity, and achieve the effect of increased porosity, fast fusion speed, and easy growth.

Inactive Publication Date: 2004-12-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, in order to increase the speed of bone fusion, high porosity is also required. For bone tissue, it must have a certain compressive strength and toughness. Once the existing calcium phosphate bioceramics increase in pore size and porosity, it is difficult to meet the requirements for bone tissue. Requirements for Compressive Strength and Toughness of Artificial Bone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Preparation of hydroxyapatite powder

[0020] Medical grade calcium carbonate (CaCO 3 ) and calcium hydrogen phosphate dihydrate (CaHPO 4 2H 2 O) is raw material, is 1.67 to take by weighing 342.2 grams of CaHPO by Ca / P mol ratio 4 2H 2 O and 134 g CaCO 3 , Pour the weighed material into a ball mill jar, add deionized water and zirconia balls. Proportioning is carried out according to the mass ratio of material: grinding ball: water of 1:3:2.2, and the mixture is ball milled at high speed for 24 hours. Then move the mixed material into a hydrothermal reaction kettle, the reaction temperature is 120°C, the pressure is 3MPa, after 40 minutes of reaction, the mixed material is taken out, dried in an oven at a constant temperature of 85°C, and calcined at 800°C for 2 hours after drying to obtain a long Acicular hydroxyapatite powder with a diameter ratio of about 10.

Embodiment 2

[0021] Embodiment 2: Preparation of nano zirconia particles

[0022] Zirconia (ZrOCl 2 ·8H 2 O) and yttrium oxide (Y 2 o 3 ) molar ratio of 97:3 mixture 450 grams, dissolved in 500 milliliters of 40 ℃ deionized water, filtered to remove impurities, to obtain Zr-containing 4+ , Y 3+ ion solution, add 1000 ml of 40 ℃ deionized water to the constant temperature container as the base liquid; add the above 500 ml of Zr 4+ and Y 3+ The solution and ammonia water with a concentration of 3N were dropped into the base liquid at the same time, and kept stirring. During the whole reaction process, the temperature of the solution was kept between 40-45°C, and the pH value was between 9-10. Continue to stir for half an hour; filter the precipitate, wash it with deionized water three times, then analyze pure ethanol twice, and wash it with AgNO 3 Detect that there is no Cl in the filtrate - ions, the filtered precipitate is dried in an oven at a temperature not exceeding 80°C, and t...

Embodiment 3

[0023] Example 3: Preparation of nano-zirconia toughened calcium phosphate artificial bone scaffold with high porosity

[0024] 1. Mix 12 grams of nano-zirconia particles prepared above and 136 grams of hydroxyapatite powder to form a composite powder, take another 98 milliliters of deionized water, add 0.7 grams of polyvinyl alcohol binder, mix well, and then add the above compound powder Powder, mixed and milled on a particle ball mill for 4 hours, the grinding balls are zirconia balls, and the slurry after mixing and grinding is poured into the storage tank; a polyurethane sponge with a porosity of 89% and a pore size of 300 μm is selected, and the 50% NaOH lye is first used After treatment, immerse in the slurry, then take out the sponge soaked in the slurry, and grind out the excess slurry in the sponge through the roller; the sponge molded body wrapped in the slurry is dried at room temperature for 12 hours, and then dried in the oven ; Then pre-fire it in the sintering fu...

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Abstract

The present invention relates to medical biological ceramic material technology, and is a kind of artificial bone rack of nano toughened calcium phosphate of high porosity. The present invention has nano zirconia grains added into calcium phosphate to raise the compression strength and toughness of artificial bone rack, so as to provide artificial bone rack of biological ceramic material with high porosity, high compression strength and high toughness. The present invention is prepared through mixing nano zirconia grain with hydroxyapatite in certain ratio to prepare slurry, painting the slurry to polyurethane sponge with proper pore size and porosity and sintering. The present invention has high porosity, proper pore size, easy absorption, fast bone tissue fusion speed and other advantages and is used in repairing damaged bone tissue and extracorporeal cell culture.

Description

technical field [0001] The invention relates to the technical field of medical bioceramic materials, and relates to a high-porosity compression-resistant and toughened bioceramic artificial bone support made of nanometer zirconia and calcium phosphate for bone defect treatment. Background technique [0002] Bone defect and nonunion caused by various reasons have always been an old problem in the field of surgery. The fundamental reason is that an ideal bone substitute has not yet been found, and its requirements are: 1. Good compatibility with human tissue and no immune source reaction; 2. Similar mechanical properties to human bone, with certain strength and support; 3. 1. It should have good osteogenic activity; 4. It is convenient to obtain materials and easy to produce in large quantities; 5. It can be absorbed and replaced by host bone tissue. In the field of bone tissue repair, the current materials are not very ideal. Traditional implant ma...

Claims

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Application Information

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IPC IPC(8): A61L27/12
Inventor 李家顺吕宏蔡舒王彦伟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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