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Chloroquine-coated denatured albumin nanoparticles for selectively resisting inflammatory cells as well as preparation method and application of chloroquine-coated denatured albumin nanoparticles

A technology of albumin nanometers and inflammatory cells, which is applied in the field of denatured albumin nanoparticles, can solve the problems of high cost of nanoparticles, difficulty in metabolism, difficulty in ensuring biological safety, etc., and achieves benefits for clinical use, simple preparation process, and improved The effect of anti-inflammatory properties

Pending Publication Date: 2022-03-08
HEFEI UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the colitis disease caused by dextran sodium sulfate and the problems of high cost, difficult metabolism and difficult guarantee of biological safety of traditional nanoparticles, the present invention constructs a chloroquine-encapsulated drug for selective anti-inflammatory cells Denatured albumin nanoparticles and their application in the treatment of colitis disease caused by dextran sodium sulfate DSS

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  • Chloroquine-coated denatured albumin nanoparticles for selectively resisting inflammatory cells as well as preparation method and application of chloroquine-coated denatured albumin nanoparticles
  • Chloroquine-coated denatured albumin nanoparticles for selectively resisting inflammatory cells as well as preparation method and application of chloroquine-coated denatured albumin nanoparticles
  • Chloroquine-coated denatured albumin nanoparticles for selectively resisting inflammatory cells as well as preparation method and application of chloroquine-coated denatured albumin nanoparticles

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Embodiment 1

[0038] This embodiment prepares denatured albumin nanoparticles wrapped with chloroquine as follows:

[0039] 80mg bovine serum albumin was dissolved in 4mL deionized water to obtain a solution of bovine serum albumin with a concentration of 20mg / mL; 16mg chloroquine was dissolved in 320 μL dimethyl sulfoxide to obtain a concentration of chloroquine solution of 50mg / mL; Add the chloroquine solution to the bovine serum albumin solution, then stir the reaction with a stirring speed of 1600rpm at room temperature for 15min; then add 14mL absolute ethanol dropwise, and stir the reaction at room temperature for 1h at a stirring speed of 600rpm after the addition is completed, then Add 320 μL of glutaraldehyde solution with a mass concentration of 2%, and react in the dark for 12 hours: centrifuge the obtained product (centrifugation temperature is 4°C, 18000-20000g rotation speed), and wash with water to obtain denatured albumin nanoparticles wrapped with chloroquine.

[0040] fig...

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Abstract

The invention discloses a chloroquine-coated denatured albumin nanoparticle for selectively resisting inflammatory cells as well as a preparation method and application thereof, and the denatured albumin nanoparticle is used as a carrier and is coated with a drug chloroquine. The nanoparticles have good stability and biocompatibility, can be efficiently internalized by macrophages, and can effectively aim at inflammatory cells at colon parts, so that inflammation is relieved, and the nanoparticles are used for treating colitis diseases caused by dextran sodium sulfate.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, in particular to denatured albumin nanoparticles coated with chloroquine for selectively resisting inflammatory cells. Background technique [0002] Inflammatory disease (Inflammatory bowel disease, IBD) is a digestive system disease, roughly divided into two categories: ulcerative colitis and Crohn's disease, can involve the entire digestive tract, mainly ileum, colon and cecum inflammation. The pathogenesis and cause of the disease are still unclear. The main symptoms are persistent diarrhea, weight loss, fatigue, blood in the stool and abdominal pain. IBD is generally considered to be a chronic, relapsing disease caused by the interaction of multiple factors such as genetic susceptibility, intestinal immune abnormality, flora imbalance, and environment. With the improvement of the national economy and the gradual westernization of the national lifestyle, the number of cases of inflammat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/4706A61K47/42A61P1/00A61P29/00B82Y5/00B82Y40/00
CPCA61K31/4706A61K9/5169A61P1/00A61P29/00B82Y5/00B82Y40/00
Inventor 查正宝马玉佩
Owner HEFEI UNIV OF TECH
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