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Preparation method of calcium carbonate film layer on surface of biomedical degradable metal material

A metal material and biomedical technology, which is applied in the preparation of calcium carbonate film on the surface of biomedical degradable metal materials, and in the field of modified coatings, can solve the problems of insufficient corrosion resistance and protection performance, and achieve excellent biocompatibility and preparation The method is simple and gentle, and the effect of controllable shape

Active Publication Date: 2022-02-08
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the cubic structure of calcium carbonate crystals, and its large grain size, it is prone to the disadvantage of insufficient corrosion protection performance in the test solution

Method used

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  • Preparation method of calcium carbonate film layer on surface of biomedical degradable metal material
  • Preparation method of calcium carbonate film layer on surface of biomedical degradable metal material
  • Preparation method of calcium carbonate film layer on surface of biomedical degradable metal material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: a kind of preparation method of biomedical degradable metal material surface calcium carbonate film layer, comprises the following steps:

[0031] S1. Pretreatment of the surface of medical metal materials: Use water-grinding paper to polish the surface of the magnesium alloy step by step, then ultrasonically clean it with absolute ethanol for 5-10 minutes, and dry it with air;

[0032] S2, the preparation of mixed solution: prepare calcium chloride, the mixed solution of sodium carbonate concentration of 50mM with water, adjust the pH value of mixed solution to 7.3 with dilute NaOH solution;

[0033] S3. Preparation of the film layer: immerse the magnesium alloy pretreated in step S1 into the mixed solution prepared in step S2, heat it at a constant temperature to 80°C, keep it for 2 hours, take out the magnesium alloy and rinse it with deionized water, and dry it naturally , that is, a calcium carbonate film is prepared on the surface of the magnesium al...

Embodiment 2

[0036] Embodiment 2: a kind of preparation method of biomedical degradable metal material surface calcium carbonate film layer, comprises the following steps:

[0037] S1. Pretreatment of the surface of medical metal materials: Use water-grinding paper to polish the surface of the magnesium alloy step by step, then ultrasonically clean it with absolute ethanol for 5-10 minutes, and dry it with air;

[0038] S2, the preparation of mixed solution: prepare the mixed solution of calcium chloride, sodium carbonate, magnesium sulfate concentration all is 50mM with water, adjust the pH value of mixed solution to 7.3 with dilute NaOH solution;

[0039] S3. Preparation of the film layer: immerse the metal material pretreated in step S1 into the mixed solution prepared in step S2, heat it at a constant temperature to 80°C, keep it for 2 hours, take out the magnesium alloy and rinse it with deionized water, and dry it naturally , that is, a calcium carbonate film is prepared on the surfa...

Embodiment 3

[0043] The difference between the steps in the preparation method and Example 2 is: the calcium chloride with a concentration of 50 mM in the mixed solution in step S2 is replaced with calcium acetate with a concentration of 50 mM to obtain a calcium carbonate film layer with better corrosion resistance.

[0044] The prepared calcium carbonate film has an effective thickness of 3-5 μm, and the calcium carbonate film can increase the electrochemical corrosion resistance of the magnesium alloy by 8 times after being tested in artificial simulated body fluid for 3 days.

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Abstract

The invention discloses a preparation method of a calcium carbonate film layer on the surface of a biomedical degradable metal material, belonging to the technical field of biomedical coating material preparation. The preparation method comprises the following preparation steps: pretreating the surface of a medical metal material through waterproof abrasive paper; mixing calcium salt, carbonate, an additive and water to prepare a mixed solution, and adjusting the pH value of the mixed solution; and immersing the pretreated metal material into the prepared mixed solution, and keeping a constant temperature for a certain time to form a calcium carbonate film layer on the surface of the metal material. According to the invention, the calcium carbonate film layer prepared by using the inorganic magnesium salt and the organic molecular additive is controllable in morphology, uniform and compact, good in binding force with a metal material matrix, excellent in biocompatibility, biological activity and biodegradability, and capable of remarkably improving the corrosion resistance of the metal material; and meanwhile, the preparation method is simple, mild, green, environment-friendly and low in cost, and has the prospect of being applied to biomedical metal materials on a large scale.

Description

technical field [0001] The invention relates to a modified coating of a biomedical metal material, in particular to a method for preparing a calcium carbonate film layer on the surface of a biomedical degradable metal material, and belongs to the technical field of biomedical coating material preparation. Background technique [0002] Biomedical metal materials have excellent properties such as fatigue resistance, high toughness, high strength and easy processing, and are currently the most widely used force-bearing implant materials. After biomedical degradable metal materials are implanted into the human body, the corrosion of the physiological environment will lead to premature failure of the implanted materials. The metal ions released during the corrosion process may cause inflammation and cause tissue damage. Therefore, excellent corrosion resistance and biocompatibility are the performance indicators that biomedical degradable materials must possess. [0003] Modifyi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/28A61L27/04A61L27/50A61L27/58
CPCA61L27/306A61L27/28A61L27/047A61L27/50A61L27/58A61L2400/18A61L2420/02A61L2420/04
Inventor 侯瑞青蒋平丽朱世杰关邵康
Owner ZHENGZHOU UNIV
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