Degradable nano-hydroxyapatite magnesium-based composite material and preparation method thereof

A technology of hydroxyapatite and hydroxyapatite powder, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., to improve the living environment of cells, increase the degree of alloying and strength, and inhibit corrosion

Inactive Publication Date: 2021-04-30
HOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of too fast corrosion rate of existing magnesium alloy bone implant materials, the present invention provides a degradable nano-hydroxyapatite magnesium-based composite material and a preparation method thereof

Method used

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  • Degradable nano-hydroxyapatite magnesium-based composite material and preparation method thereof
  • Degradable nano-hydroxyapatite magnesium-based composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Raw material preparation: select high-purity magnesium powder with a particle size of about 60 μm (purity ≥ 99.9%), high-purity zinc powder with a particle size of about 10 μm (purity ≥ 99.9%), and analyze pure nano-hydroxyphosphorus with a particle size of ≤ 60 nm Ash stone powder (HA). Weigh and prepare separately according to the weight ratio of 91:4:5.

[0026] (2) Powder mixing: Mix the weighed powders together and pour them into a star-shaped powder mixer. Because the chemical properties of magnesium powder are active, it is easy to cause danger if the powder mixer turns too fast, and it is difficult to achieve a uniform mixing if it is too slow. Therefore, set the speed of the mixer to 20r / min and the mixing time to 80 hours. When the time is up, turn off the powder mixer, take out the raw material powder mixed in proportion and pack it into bags.

[0027] (3) Cold extrusion: Pour the wrapped powder into the cold extrusion mold, install the mold, apply pres...

Embodiment 2

[0031] (1) Raw material preparation: select high-purity magnesium powder with a particle size of about 60 μm (purity ≥ 99.9%), high-purity zinc powder with a particle size of about 10 μm (purity ≥ 99.9%), and analyze pure nano-hydroxyphosphorus with a particle size of ≤ 60 nm Ash stone powder (HA). Weigh and prepare separately according to the weight ratio of 86:4:10.

[0032] (2) Perform powder mixing, cold pressing, and sintering according to the steps (2)-(4) in Example 1.

[0033] (3) The Mg-Zn / 10HA composite material was prepared according to the above procedures, and its microstructure was attached figure 2 As shown, the alloying degree of magnesium powder and zinc powder is good, and the XRD test forms MgZn2 phase, HA powder evenly fills the alloy pores, does not react with the alloy powder after sintering, maintains its biological activity, and is still uniformly distributed at the grain boundary of the matrix. Alloy hardness is 56HRB. The results of electrochemica...

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Abstract

The invention discloses a degradable nano-hydroxyapatite magnesium-based composite material and a preparation method thereof. The degradable nano-hydroxyapatite magnesium-based composite material comprises the following components in percentage by weight: 4wt.% of Zn, 5wt.%-20wt.% of nano-hydroxyapatite powder (HA) and the balance of Mg. By adding 4wt.% of alloy element Zn, the alloying degree, strength and corrosion resistance of the Mg / Zn powder are improved; hydroxyapatite (HA) is selected as a reinforcing body, a powder metallurgy method is adopted, pores between Mg / Zn powder are effectively filled, and the compactness and toughness of the material are further improved. HA can effectively adsorb hydrogen generated by corrosion of an alloy matrix, a protective layer is formed through induction, and the alloy degradation rate is controlled. By adding HA, alkalization of magnesium matrix corrosion to surrounding matrix tissues is relieved, and the living environment of cells is improved. The Mg-Zn / HA composite material which is uniform and compact in structure, good in alloying and good in corrosion resistance is prepared by designing the component proportion of Mg / Zn and Mg-Zn / HA and powder metallurgy process parameters, and the Mg-Zn / HA composite material has the value of being used as a biological bone implant material for clinical application.

Description

technical field [0001] The invention relates to a degradable nano-hydroxyapatite magnesium-based composite material and a preparation method thereof, belonging to the technical field of preparation and application of magnesium-based biomedical materials. Background technique [0002] Biomedical materials are high-tech materials used to diagnose, repair or enhance the functions of human tissues and organs. They are natural or artificial materials used to replace and repair living tissues, and have irreplaceable effects of drugs. Among them, hard tissue implant materials, including various human bone repair and replacement materials, such as bones, teeth, joints, etc., have become the main field of biomaterials in medicine due to their wide application and large demand. Ideal hard tissue implant materials must have good biocompatibility, comparable bending strength, low stress shielding effect, and less impact on bone and blood circulation. [0003] Compared with any other me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50A61L27/04A61L27/54C22C23/00C22C32/00C22C1/05
CPCA61L27/12A61L27/50A61L27/047A61L27/54C22C23/00C22C32/0089C22C1/05A61L2400/12A61L2430/02A61L2300/112A61L2300/412
Inventor 袁玉春李康陈怡斐王欢刘欢吴玉娜宋丹江静华马爱斌
Owner HOHAI UNIV
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