U-shaped bone nail having muscle/bone induction activity and realizing flexible connection after degradation

Abstract

The invention discloses a U-shaped bone nail having muscle/bone induction activity and realizing flexible connection after degradation. The U-shaped bone nail is a U-shaped structural member composedof two nail feet and a nail foot connector, and a composite bar comprises titanium alloy spheres, a carbon fiber bundle, a niobium wire layer, a magnesium alloy layer, a zinc alloy layer, a nail footcoating and a nail foot connector coating. The U-shaped bone nail has enough rigidity and strength at the initial stage of an operation; osteoinductive activity is obtained at the contact positions ofthe two nail feet and a bone; and muscle growth inductive activity is achieved at the contact positions of the connector of two nail feet and muscles. After the coatings, zinc alloy and magnesium alloy are degraded, a healed skeletal joint still has high-strength flexible connection in virtue of the carbon fiber bundle and the niobium wire sleeving the carbon fiber bundle; and the titanium alloyspheres at the two ends can fix the carbon fiber bundle, so it is guaranteed that the skeletal joint cannot crack when the skeletal joint is impacted by external force. The invention also provides a preparation method of the U-shaped bone nail having muscle/bone induction activity and realizing flexible connection after degradation. The method has the characteristics of easiness in operation and convenience in industrial production.

Description

technical field [0001] The invention relates to the technical field of new medical materials, in particular to U-shaped bone nails with muscle / bone induction activity after degradation and flexible connection. Background technique [0002] At present, the bone nail is a common orthopedic implant connector, and is currently widely used in the treatment of orthopedic diseases. The purpose of U-shaped bone nail is mainly: the connection of two sections of bones after the fracture, although the whole piece of bone is not completely broken but there is a reinforced connection of larger cracks. [0003] There are three types of U-shaped bone screws commonly used at present: one is rigid bone screws made of stainless steel, titanium and titanium alloys, Co-Cr alloys, etc.; the other is rigid bone screws made of biodegradable materials such as polymer materials, magnesium alloys, and zinc alloys. The third is two rigid nail feet and a semi-rigid and semi-flexible bone nail connecte...

AI Technical Summary

Problems solved by technology

However, the mechanical strength of degradable polymer materials is low, and accidents such as fractures often occur during clinical use, which greatly limits the clinical applicability; degradable magnesium alloy bone screws have the problem of excessive degradation, and there are also serious problems. The phenomenon of pitting corrosion causes the material to lose its mechanical support prematurely. Although a large number of literatures have proposed a variety of solutions, there is still the problem of too fast degradation of pitting corrosion, which cannot meet the needs of patients; if zinc alloy is used to make bone nails, It can effectively reduce its degradation rate, but there are problems such as low mechanical strength; if the bimetallic structure of outer zinc and inner magnesium is used to manufacture bone nails, it can not only ensure the mechanical properties but also degrade and disappear after bone healing, but the healed bone is combined It is still a weak link, and there is still a risk of cracking after movement or impact by external forces

[0006] The third type of bone nail uses elastic material at the middle connection of the U-shaped structure, and the healed bone joint is not easy to crack after movement or impact by external force, but it has no rigid fixation effect on the connecting bone at the initial stage of the treatment of orthopedic diseases. , prone to problems such as dislocation of connecting bones, resulting in failure of treatment operations

[0007] The above three types of bone nails all have problems such as no osteoinductive activity and failure to promote the growth of the body at the point of contact with the muscle.

[0008] The patent application number 201811519979.8 discloses a degradable magnesium alloy bone nail with a scaly bone-like nanostructure coating and its preparation method. The bone nail is loaded with a magnesium oxide bioceramic coating with a scale-like bone-like nanostructure from a magnesium alloy matrix. PLGA-bone morphogenetic protein BMP, has a certain osteoinductive activity and the material can be degraded, but there are the following problems: ①The healed bone junction is a weak link. There is still a risk of cracking after the impact; ②If the U-shaped bone nail is made, there will be no muscle growth-inducing activity at the place where the middle connection of the U-shaped structure contacts the muscle; Corrosion and degradation are very easy to occur...

Images