Drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, preparation method and application thereof

A mesoporous hydroxyapatite, biomedical technology, applied in the field of biomedicine, can solve the problems of large diameter of hydroxyapatite particles, difficult to meet individual application requirements, affecting the mechanical properties of composite materials, etc., to improve the success rate of surgery , Improve the interface compatibility, improve the effect of drug loading rate and encapsulation rate

Active Publication Date: 2022-05-13
GUANGZHOU FEISHENG HIGH POLYMER MATERIAL CO LTD +1
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method improves the dispersion of hydroxyapatite in the polylactic acid matrix and increases the interfacial bonding strength, but the tetrahydrofuran introduced by this method has biological toxicity, which increases the safety hazard for the material
Chinese patent 201610835592.8 introduces a solution blending and hot pressing preparation method of stearic acid-modified hydroxyapatite / poly-L-lactic acid composite material, which improves the interfacial bonding between hydroxyapatite and polylactic acid, but the The particle diameter of the hydroxyapatite used is relatively large, and it is difficult to make it completely and evenly dispersed in the matrix solution by ultrasonic dispersion, which affects the mechanical properties of the composite material
Chinese patent CN105000569B discloses a mesoporous magnesium silicate / hydroxyapatite / polyether ether ketone composite material, bone restoration and its preparation method and application. The mesoporous magnesium silicate / hydroxyapatite / polyether ether The preparation method of the ketone composite material is: uniformly mixing 15wt% to 20wt% of mesoporous magnesium silicate, 10wt% to 15wt% of hydroxyapatite and 65wt% to 75wt% of polyetheretherketone to obtain a mixed powder; The mixed powder is mixed with absolute ethanol, ultrasonically dispersed, and then evaporated at 65°C to 80°C to obtain a composite powder, which is prepared by molding the composite powder. The molding process is more complicated and relatively Difficult to meet various personalized application requirements in the field of biomedicine
[0005] Therefore, although mesoporous hydroxyapatite has been rarely studied in bone repair in the prior art, drug-loaded modified mesoporous hydroxyapatite biomedical composite materials and wires suitable for 3D printing have not been reported. There are few reports on the preparation methods, and there are difficulties in industrialization methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, preparation method and application thereof
  • Drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, preparation method and application thereof
  • Drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing is composed of polymer polylactic acid and drug-loaded modified mesoporous hydroxyapatite nano-microspheres in the following parts by weight Prepared from:

[0040] Polylactic acid: 95 parts,

[0041] Drug-loaded modified mesoporous hydroxyapatite nanospheres: 5 parts;

[0042] Wherein, the preparation method of drug-loaded modified mesoporous hydroxyapatite nanospheres adopts the following steps:

[0043] (1) ① Calcium nitrate (Ca(NO 3 ) 2 .4H 2 O) and ammonium dihydrogen phosphate (NH 4 h 2 PO 4 ) were dissolved in water respectively, with NH 3 .H 2 O adjusts the pH of the solution so that the pH is 9. Weigh cetyltrimethylammonium bromide (CTAB) and add to Ca(NO 3 ) 2 .4H 2 In O solution, CTAB: Ca(NO 3 ) 2 .4H 2 O: water = 0.5g: 0.2g: 100ml, water bath temperature 90°C, magnetic rotation speed 500rpm and stir for 30min, the solution turns into a milk...

Embodiment 2

[0052] A drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing is composed of polymer polycaprolactone and drug-loaded modified mesoporous hydroxyapatite nano-microspheres in the following parts by weight The components are prepared from:

[0053] Polycaprolactone: 90 parts,

[0054] Drug-loaded modified mesoporous hydroxyapatite nanospheres: 10 parts;

[0055] Wherein, the preparation method of drug-loaded modified mesoporous hydroxyapatite nanospheres adopts the following steps:

[0056] (1)①Calcium ammonium nitrate (5Ca(NO 3 ) 2 ·NH 4 NO 3 10H 2 O) and ammonium dihydrogen phosphate (NH 4 h 2 PO 4 ) were dissolved in water respectively, with NH 3 .H 2 O adjusts the pH of the solution so that the pH is 10. Weigh dodecyl phosphate (MAP) and add to 5Ca(NO 3 ) 2 ·NH 4 NO 3 10H 2 In O solution, MAP: 5Ca(NO 3 ) 2 ·NH 4 NO 3 10H 2 O: water = 1g: 0.5g: 100ml, water bath temperature 90°C, magnetic rotation speed 30...

Embodiment 3

[0065] A drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing is composed of polymer polylactic acid and drug-loaded modified mesoporous hydroxyapatite nano-microspheres in the following parts by weight Prepared from:

[0066] Polylactic acid: 85 parts,

[0067] Drug-loaded modified mesoporous hydroxyapatite nanospheres: 15 parts;

[0068] Wherein, the preparation method of drug-loaded modified mesoporous hydroxyapatite nanospheres adopts the following steps:

[0069] (1) ① Calcium phosphate (Ca 3 (PO 4 ) 2 2H 2 O) and ammonium phosphate ((NH 4 ) 3 PO 4 ) were dissolved in water respectively, with NH 3 .H 2 O adjusts the pH of the solution so that the pH is 10. Weigh cetyltrimethylammonium bromide (CTAB) and add to Ca 3 (PO 4 ) 2 2H 2 O solution, CTAB:Ca 3 (PO 4 ) 2 2H 2 O·10H 2 O: water = 1.5g: 0.4g: 100ml, water bath temperature 90°C, magnetic rotation speed 300rpm, stir for 40min, the solution turns into a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
specific surface areaaaaaaaaaaa
pore sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, a preparation method and an application thereof. Porous hydroxyapatite, and then use coupling agent to modify mesoporous hydroxyapatite to prepare drug-loaded modified nanospheres with loaded mesoporous materials; The polymers are blended and stirred to finally obtain a biomedical composite material suitable for 3D printing. The biomedical composite material of the present invention has good mechanical properties, high drug loading and encapsulation efficiency, and good biocompatibility, and is convenient for production and processing, easy to prepare, and can be printed individually. In the field of medicine, especially in the field of bone repair, it can induce the growth of bone tissue, promote the repair of bone tissue, and provide a new way to reduce the pain of patients and improve the success rate of surgery.

Description

technical field [0001] The invention belongs to the field of biomedicine and new material processing technology, and specifically relates to a drug-loaded modified mesoporous hydroxyapatite biomedical composite material suitable for 3D printing, a preparation method and an application thereof. Background technique [0002] According to the public report of IUPAC, when the diameter of the material is 2-50nm, the material is called mesoporous material. Compared with other materials, mesoporous materials have the advantages of large specific surface area, regular channels, and adjustable pore diameters. Based on the above advantages, mesoporous materials have been widely used in biomaterials, catalysis and other fields. The structure and composition of hydroxyapatite are similar to those of natural apatite. It exists in large quantities in human bones and teeth, accounting for 60% and 97% respectively, and has good biocompatibility. At the same time, mesoporous hydroxyapatite...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/50A61L27/54A61L27/56
CPCA61L27/46A61L27/56A61L27/50A61L27/54A61L2430/02A61L2300/602A61L2300/802C08L67/04
Inventor 周武艺万美玲董先明谷文亮聂健良
Owner GUANGZHOU FEISHENG HIGH POLYMER MATERIAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap