A kind of electrospinning nanofiber preparation process

Abstract

The invention discloses a preparation process of electrospinning nanofibers. In step 1, gelatin is added to anhydrous acetic acid, then polycaprolactone is added, and stirred at low temperature for 18-24 hours to obtain a mixed acetic acid solution; in step 2, hydroxyl phosphorus Limestone powder, dandelion extract and magnesium alloy particles are added to the sealed ball milling device for low-temperature wet ball milling for 30-60 minutes, and dried to obtain a mixed solid; step 3, slowly add the mixed solid to the mixed acetic acid solution at room temperature and stir evenly, microwave at low temperature React for 1-3 hours to obtain the precursor spinning solution; step 4, slowly add distilled water and glutaraldehyde to the precursor spinning solution and stir evenly at low temperature to obtain the spinning solution, and then perform electrospinning to obtain the nanofiber membrane; step 5 , the nanofibrous membrane is rolled into a fiber column, and then gradiently heated for 12‑24h to obtain a nanofibrous scaffold. The invention uses gelatin and polycaprolactone as a double support structure to form a slow-release structure, controls the exposed area of ​​the magnesium alloy and the hydroxyapatite, and thereby controls the degradation rate.

Description

technical field [0001] The invention belongs to the field of nanofibers, and in particular relates to a preparation process of electrospinning nanofibers. Background technique [0002] Bone defects and osteonecrosis caused by trauma, inflammation, bone tumor removal, etc. are common clinical orthopedic operations. At present, bone repair materials such as stainless steel, titanium alloys, polymers and ceramics are often used clinically for the repair and reconstruction of bone defects. Due to the limitations of its own physical, chemical and biological properties, the effect of bone repair still needs to be improved. [0003] Magnesium is an essential trace element for the human body. A certain concentration of magnesium ions can promote the proliferation and differentiation of chondrocytes, which is beneficial to the formation of cartilage. When magnesium alloys are implanted in the human body, phosphates that can be transformed into new bone tissue will be generated on the...

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems in the prior art, the present invention provides a preparation process of electrospinning nanofibers, which solves the problems of poor corrosion resistance and high degradation speed of existing magnesium alloys, and uses gelatin and polycaprolactone as a double support structure to form Slow-release structure, controlling the exposed area of ​​magnesium alloy and hydroxyapatite, thereby controlling the degradation rate