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Preparing method of angiocarpy medical equipment surface Ti-Cu-N coating with antibacterial anticoagulation smooth muscle proliferation resistance functions

A medical device, ti-cu-n technology, applied in coatings, pharmaceutical formulations, metal material coating processes, etc., can solve problems such as bacterial infection, restenosis hyperplasia, thrombosis, etc., to improve the use effect and preparation cost Low, easy-to-use effects

Inactive Publication Date: 2019-08-16
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies in the prior art, the purpose of the present invention is to introduce Cu into the Ti-N coating system with good biocompatibility and mechanical properties, by changing the composition and structure of these coatings, controllable release of Cu ions and Catalyze the release of NO to achieve antibacterial, anticoagulant and anti-smooth muscle hyperplasia, so as to solve the problems of bacterial infection, thrombosis, restenosis and hyperplasia after implantation of medical devices and artificial organs

Method used

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  • Preparing method of angiocarpy medical equipment surface Ti-Cu-N coating with antibacterial anticoagulation smooth muscle proliferation resistance functions

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preparation example Construction

[0020] A preparation method for a Ti-Cu-N coating on the surface of a cardiovascular medical device, comprising the following steps:

[0021] A. Put the cardiovascular implant device into the vacuum chamber of the magnetron sputtering equipment, and the vacuum chamber is evacuated to 0.5×10 - 3 Pa–2.0×10 -3 Pa; Introduce argon gas into the vacuum chamber until the pressure is 0.5Pa-2.0Pa, form plasma through glow discharge, sputter and clean the workpiece and sputtering target for 5-100 minutes, then turn off the argon gas and power supply;

[0022] B. Apply -50V bias voltage on the workpiece, the ratio of nitrogen and argon gas is 2 / 60-16 / 60, and the air pressure is 0.05-2.0Pa; connect the DC power supply on the target and turn it on, and adjust the power density on the target to about 0.5-10w / cm 2 , the Ti-Cu-N coating of the target product is prepared on the surface of the cardiovascular implant device; wherein the Cu doping amount is 5-50at%.

[0023] The preparation m...

Embodiment 1

[0025] A preparation method for a Ti-Cu-N coating on the surface of a cardiovascular medical device, comprising the following steps:

[0026]A. Put the cobalt-chromium-molybdenum alloy cardiovascular implant device into the vacuum chamber of the magnetron sputtering equipment, and the vacuum chamber is evacuated to 2.0×10 -3 Pa; Introduce argon gas into the vacuum chamber until the pressure is 2.0Pa; apply a DC voltage of -1000V to the workpiece, form plasma through glow discharge, and sputter and clean the workpiece and the sputtering target for 10-100 minutes, and then Turn off the power; adjust the argon pressure to 0.5Pa, apply DC sputtering power to the Ti-Cu mosaic target, sputtering current 3A, generate plasma after glow discharge, clean the target for 5-30 minutes, and then turn off the argon and power supply;

[0027] B. Apply a bias voltage of -50V on the workpiece, the ratio of nitrogen and argon to 6 / 40, and the air pressure to 0.5Pa; adjust the Ti-Cu mosaic targe...

Embodiment 2

[0030] A preparation method for a Ti-Cu-N coating on the surface of a cardiovascular medical device, comprising the following steps:

[0031] A. Put the stainless steel cardiovascular implant device into the vacuum chamber of the magnetron sputtering equipment, and the vacuum chamber is evacuated to 2×10 -3 Pa; Introduce argon gas into the vacuum chamber until the pressure is 2.0Pa, apply a DC voltage of -1000V, glow discharge to form a plasma, perform sputter cleaning on cardiovascular implants for 10-100 minutes, and then turn off the DC power supply; adjust the argon The gas pressure is 0.5Pa, respectively apply DC sputtering power supply to the sputtering target Cu target and Ti target, and the sputtering current is 3A to form glow discharge and generate plasma, clean the target for 5-30 minutes, then turn off the argon gas and power supply;

[0032] B. Introduce argon and nitrogen into the vacuum chamber respectively, the ratio of nitrogen and argon is 10 / 60, until the p...

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Abstract

The invention discloses a preparing method of an angiocarpy medical equipment surface Ti-Cu-N coating with antibacterial anticoagulation smooth muscle proliferation resistance functions. The doping amount of Cu in the coating ranges from 4 to 50at%, the thickness is 0.02 micrometer, the Ti-Cu-N coating is prepared on an angiocarpy medical equipment surface through a method capable of forming Cu, Ti, N ions and atoms in the vacuum, angiocarpy medical equipment is one of metal and alloy or high polymer, a magnetron sputtering method is adopted for preparing the coating, and the sputtering targetmaterial is one of a Ti-Cu inset target, Ti and Cu double targets and a Ti-Cu alloy target. A metal cathode arc source deposition method is also adopted for preparing the coating, and the metal cathode target is one of the Ti-Cu inset target and the Ti-Cu alloy target. The prepared Ti-Cu-N coating can release Cu ions and perform catalytic releasing of NO, and the antibacterial anticoagulation smooth muscle proliferation resistance effects are achieved. The coating is used for the angiocarpy medical equipment and can solve the problems of bacterial infection, thrombogenesis and restenosis hyperplasia of medical instruments and artificial organ implantation.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a Ti-Cu-N coating used on the surface of cardiovascular medical devices, a preparation method and an application thereof. Background technique [0002] 316L stainless steel, medical cobalt alloy, ultra-high molecular weight polyethylene, polyester and other materials have good mechanical properties and biocompatibility, and are often used in the preparation of implantable medical devices such as vascular stents, artificial heart valves, and artificial blood pumps. organs; however, these implants are prone to bacterial infection in patients [Huang Yunchao, Yang Kaiyun, Lei Yujie, Zhao Guangqiang, Li Xiaoming, Gao Jia, The relationship between bacterial adhesion and bacterial growth in artificial valve materials, China Tissue Engineering Research and Clinical Rehabilitation , 2008, 12(39), 7777], and its anticoagulant performance cannot meet clinical requirements [Zhan...

Claims

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Application Information

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IPC IPC(8): C23C14/35C23C14/02C23C14/06C23C14/32A61L27/30A61L27/54A61L31/08A61L31/16
CPCA61L27/306A61L27/54A61L31/088A61L31/16A61L2300/102A61L2300/404A61L2300/416A61L2300/42A61L2400/18A61L2420/02A61L2420/06C23C14/0036C23C14/022C23C14/0641C23C14/325
Inventor 景凤娟黄斌邓乔元任倩覃利娜谢东冷永祥黄楠
Owner SOUTHWEST JIAOTONG UNIV
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