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A kind of elastic intervertebral fusion device with magnesium powder function-enhanced polymer material porous structure and preparation method thereof

A technology of polymer material and intervertebral fusion, applied in the field of medical equipment, can solve the problems of vertebral contact edge damage, limited strength, easy to cause inflammation, etc., to achieve the effect of adjusting intervertebral height, avoiding injury, and protecting bone marrow

Active Publication Date: 2021-03-23
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the strength of the PLGA / hydroxyapatite material is limited. In actual use, the fusion device degrades too quickly after being implanted in the human body, and the local acidic environment caused by the degradation process is easy to cause inflammation, and the overall structure has no shock-buffering elasticity. role, easy to cause damage to the contact edge of the vertebrae
[0004] Therefore, it is the current market demand to develop an intervertebral fusion device with good biocompatibility and osteoinductivity, high fusion rate and controllable degradation performance, but there are few reports on this direction in the market

Method used

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  • A kind of elastic intervertebral fusion device with magnesium powder function-enhanced polymer material porous structure and preparation method thereof
  • A kind of elastic intervertebral fusion device with magnesium powder function-enhanced polymer material porous structure and preparation method thereof
  • A kind of elastic intervertebral fusion device with magnesium powder function-enhanced polymer material porous structure and preparation method thereof

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preparation example Construction

[0038] A preparation method of an elastic intervertebral fusion device with magnesium powder reinforced polymer porous structure, comprising the following specific steps:

[0039] Step 1: Based on the real model of the finite element human spine, use SOLIDWORKS software to design and improve the adaptability data model of the intervertebral fusion device of this structure, and import the model program into the computer that controls the melt extrusion rapid prototyping machine superior;

[0040] Then, add the PCL particles into the cavity of the twin-screw extruder, the particle size of the PCL particles is 2-3mm, set the working temperature of the extruder at 55°C-65°C, and add the mass Magnesium powder with a fraction percentage of 10% to 20%, the particle size of the magnesium powder is 25±5μm, under the protection of inert gas, set it to the circulation banburying mode, stir for 1 hour, and the speed is 30r / min~50r / min;

[0041] When the PCL / Mg composite material is mixed...

Embodiment 1

[0048] Such as Figure 1-4 As shown, an elastic intervertebral fusion device with porous structure of magnesium powder reinforced polymer material, the main part 1 has a length of 10 mm, a width of 8 mm, and a height of 6 mm. The side length of the triangular prism of the bone graft part 2 is 0.5 mm, the length is 10 mm, and the distance between the prisms is 0.5 mm. The diameter of the piled wire material by the fused deposition method is 0.3mm, and the number of piled up layers is 20 layers. The gradient distribution of pore size from the first layer to the twentieth layer is 600 μm, 620 μm, 640 μm, 660 μm, 680 μm, 700 μm, 720 μm, 740 μm, 760 μm, 780 μm, 780 μm, 760 μm, 740 μm, 720 μm, 700 μm, 680 μm, 660 μm, 640 μm , 620μm, 600μm, the porosity is 80%.

[0049] The preparation method of the elastic intervertebral fusion device with the porous structure of the above-mentioned magnesium powder reinforced polymer material is as follows:

[0050] Step 1, set up this model in ...

Embodiment 2

[0055] An elastic intervertebral fusion device with magnesium powder reinforced polymer material porous structure, the main part 1 of which has a length of 20 mm, a width of 10 mm and a height of 8 mm. The side length of the triangular prism of the bone graft part 2 is 0.6 mm, the length is 20 mm, and the distance between the prisms is 0.6 mm. The diameter of the piled wire material by the fused deposition method is 0.4mm, and the number of piled up layers is 20 layers. The gradient distribution of pore size from the first layer to the twentieth layer is 700 μm, 720 μm, 740 μm, 760 μm, 780 μm, 800 μm, 820 μm, 840 μm, 860 μm, 880 μm, 880 μm, 860 μm, 840 μm, 820 μm, 800 μm, 780 μm, 760 μm, 740 μm , 720μm, 700μm, the porosity is 82%.

[0056] The preparation method of the elastic intervertebral fusion device with the porous structure of the above-mentioned magnesium powder reinforced polymer material is as follows:

[0057] Step 1, set up this model in SOLIDWORKS software, and ...

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Abstract

The invention discloses an elastic interbody fusion cage having a biodegradable magnesium powder function reinforced high molecular material porous structure and a preparation method of the elastic interbody fusion cage. The elastic interbody fusion cage mainly consists of a main body part and a bone grafting part, wherein the main body part is a porous magnesium reinforced composite material hexahedron having gradient bore diameter distribution, and the bone grafting part consists of a plurality of bar-shaped sawteeth. A medical coating having a bone induction effect and an inflammation resisting effect covers the inner part and the surface of the fusion cage. The preparation method comprises the steps of performing high-temperature melting on PCL granules, mixing the melted PCL granuleswith magnesium powder to obtain composite material granules, and then performing integral shaping by a melting and deposition method. The elastic gradient bore diameter structure of the elastic interbody fusion cage disclosed by the invention is well matched with the elasticity modulus of human bones, and the fusion rate is increased. By the integral shaping method, the mechanical intensity of thefusion cage is increased, release of magnesium ions in the degradation process achieves the effect of acid and base neutralization, and the degradation rate is adjusted and controlled to be in a reasonable range.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an elastic intervertebral fusion device with biodegradable magnesium powder function-enhanced polymer material porous structure, and also relates to a preparation method of the elastic intervertebral fusion device. Background technique [0002] With the development of society, human working methods and lifestyles have undergone major changes, and the number of people who need to work at desks is increasing. In addition, the aging trend of society is increasing. Relevant epidemiological surveys suggest that: 58-84% of adults Workers are troubled by different degrees of spinal diseases, such as cervical spondylosis, lumbar disc herniation, spinal stenosis, spondylolisthesis, discogenic low back pain, degenerative scoliosis, etc. As a common disease, spinal disorders have received extensive attention for their treatment. Early spinal fusion techniques included s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/44B29B9/06B29C48/92B29C64/118B33Y10/00
CPCA61F2/30942A61F2/4455A61F2250/0067A61F2310/00041B29B9/06B33Y10/00B29C64/118
Inventor 白晶倪雅文周星星薛烽张越周健
Owner SOUTHEAST UNIV
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