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A controllable biodegradable copolymer with basic copolymerization center

一种共聚物、碱性的技术，应用在高分子材料,制备组织工程领域，能够解决降低材料力学性能、降低组织pH值、不利患者健康等问题，达到改善组织pH值的影响、改善结晶性能、提高亲水性和生物相容性的效果

Active Publication Date: 2022-04-12
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology only uses a simple mechanical blending method to modify polylactic acid and its derivatives. There is no effective bonding between the basic additives and the polymer matrix, and the basic substances are easy to agglomerate in the polymer matrix. , and thus cause a weak point between the two phases, greatly reducing the mechanical properties of the material
Patent CN 1872355A reports that the polypeptide chain segment arginine-glycine-aspartic acid is introduced into the end group of the polymer, but the polypeptide also contains an acidic amino acid-aspartic acid, which will further reduce the pH value of the tissue during the degradation process. good for patient health

Method used

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  • A controllable biodegradable copolymer with basic copolymerization center
  • A controllable biodegradable copolymer with basic copolymerization center
  • A controllable biodegradable copolymer with basic copolymerization center

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] The preparation method of the basic copolymerization center is as follows: dissolving carboxypolyethylene glycol in deionized water, then adding EDCI to the above solution for 45 minutes of reaction; adding amino acid into the activated carboxypolyethylene glycol solution, and using 1M HCl Adjust the pH value to 4, continue the reaction at room temperature for 2 hours, and then the pH value rises to 6 and continue the reaction for 1 hour; the product is dialyzed in 1 mM hydrochloric acid solution at 10°C, repeat the dialysis twice (add 1% sodium chloride to the dialysate), and freeze-dry .

[0054] The preparation method of the copolymer: mix the basic copolymerization center, left-handed, right-handed lactide, and caprolactone, and add them to the reactor. After mixing, repeatedly vacuumize and fill with nitrogen for 20 times; Add a ring-opening polymerization catalyst to the reactor, heat the reactor to the corresponding temperature, and react for a certain period of ...

Embodiment 5

[0063] The tensile property research of embodiment 5 copolymers

[0064] Table 3 copolymer performance and its tensile performance comparison

[0065]

[0066] Lactide L / D in the above table refers to the feed ratio when L-lactide and D-lactide are polymerized

[0067] The detection of polymer intrinsic viscosity is based on GB / T 1632.1-2008 plastics, using a capillary viscometer to measure the viscosity of dilute polymer solutions, and the tensile strength and elongation at break are based on GB / T 1040.3-2006 Determination of tensile properties of plastics No. 3 Part: The test conditions for thin plastics and thin sheets are carried out. Dispersion is determined by GPC. As can be seen from Table 5, in 3 kinds of copolymers provided by the present invention, add multi-arm copolymerization center, PEG compared with non-added copolymer (comparative example 1,3), elongation at break has obvious increase, illustrates that the present invention provides The copolymer has high...

Embodiment 6

[0068] Example 6 Cytocompatibility and degradation solution pH of basic copolymerization center copolymer

[0069] 6.1 Cytocompatibility experiments of copolymers

[0070] The copolymers in Examples 1-4 and Comparative Examples 3-4 were hot-pressed into a film with a thickness of 0.2mm at 150°C and 9MPa with a flat bed, and then cut into discs with a diameter of 15mm, according to The sequence of ethanol, tap water and three-distilled water was washed three times repeatedly, and then washed three times with sterilized three-distilled water. After washing, it was fixed on the bottom of the well of the tissue culture plate, and after ultraviolet sterilization, 1 mL of cells was added to each well of the tissue culture plate. Suspension (1×10 5 cells / mL), at 37°C, 5% CO 2 After cultivating in an incubator with saturated humidity for a certain period of time, observe the cell morphology with a microscope, then remove the culture medium, wash away non-adherent cells with buffer, ...

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Abstract

The invention provides a controllable biodegradable copolymer with an alkaline copolymerization center; a copolymer prepared from lactide, caprolactone and alkaline copolymerization centers with different optical rotation ratios, the copolymer can improve the The pH drop caused by the degradation of PLA improves the biocompatibility of the copolymer. The biodegradable copolymer provided by the invention has excellent mechanical strength, biocompatibility and pH adjustment function, and can be widely used in carriers or devices used in the field of tissue engineering, especially in the preparation of nerve conduits.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to a controllable biodegradable copolymer with a basic copolymerization center and its application in the preparation of carriers or devices used in the field of tissue engineering. Background technique [0002] According to the source, biodegradable polymers can be divided into two categories: natural and synthetic. Natural degradable polymers include chitosan, chitin and their derivatives, etc.; synthetic degradable polymers are divided into two categories: artificial synthesis and bacterial synthesis. . Degradable polymers synthesized by bacteria include polyhydroxyalkanol esters and polyB 2 Glucose esters, etc., synthetic degradable polymers include aliphatic polyesters, polyamino acids, and polyphosphazenes, among which polyesters are currently the only type of biodegradable materials approved by the US FDA for use in the biomedical field. The more commonly used ones are: polyl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/685C08G63/85C08G65/333
CPCC08G63/6852C08G63/823C08G65/33306C08G65/333C08G2230/00
Inventor 冷鸿飞徐小雨刘培岩尚丽霞陶秀梅陈鹏
Owner NKD PHARMA CO LTD
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