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Nanometer bone repairing material and preparation method thereof

A kind of bone repair and nanotechnology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of unstable degradation rate and performance, poor mechanical properties of natural polymer materials, etc., to inhibit osteoclast differentiation, improve Brittleness and mechanical properties, effect of accelerated nucleation

Inactive Publication Date: 2018-05-25
常州琨瑶纺织品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problems of poor mechanical properties, degradation rate and unstable performance of natural polymer materials, a nano-bone repair material and its preparation method are provided

Method used

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  • Nanometer bone repairing material and preparation method thereof

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example 1

[0029]Take 300g of pearls, wash them, air-dry them naturally, put them into a grinder, and grind them through a 400-mesh sieve. Take 100g of sieved pearl powder and add them to 10kg of 1% ethylenediaminetetraacetic acid aqueous solution at 40°C. Stir at 300r / min for 1h, cool to room temperature, put it into a centrifuge, centrifuge at 6000r / min for 10min, remove the precipitate, put it in a vacuum freeze-drying oven, and dry at -30°C for 20h to obtain pearl protein. Take 300g of fresh For catfish swim bladder, remove the blood vessels and mucous membranes in the swim bladder, wash the swim bladder with deionized water for 3 times, drain the washed swim bladder, soak it in 3kg of 5% sodium carbonate solution, stir at 300r / min for 8h, take out Wash the swim bladder with deionized water until the washing liquid is neutral, air-dry it naturally, put it into a pulverizer and crush it, pass through a 60-mesh sieve to obtain a pretreated swim bladder, take 100g of the pretreated swim ...

example 2

[0031] Take 400g of pearls, wash them, dry them naturally, put them into a grinder, and grind them through a 400-mesh sieve. Take 150g of sieved pearl powder and add them to 15kg of 1% ethylenediaminetetraacetic acid aqueous solution. Stir at 350r / min for 1h, cool to room temperature, put it into a centrifuge, centrifuge at 7000r / min for 12min, remove the precipitate, put it in a vacuum freeze-drying oven, and dry at -25°C for 22h to obtain pearl protein. Take 400g of fresh Catfish swim bladder, remove the blood vessels and mucous membranes in the swim bladder, wash the swim bladder with deionized water 4 times, drain the washed swim bladder, soak in 4kg of 5% sodium carbonate solution, stir at 350r / min for 9h, take out Wash the swim bladder with deionized water until the washing liquid is neutral, air-dry it naturally, put it into a pulverizer and crush it, pass through a 60-mesh sieve to obtain a pretreated swim bladder, take 150g of the pretreated swim bladder and add it to ...

example 3

[0033] Take 500g of pearls, wash them, dry them naturally, put them into a grinder, and grind them through a 400-mesh sieve. Take 200g of sieved pearl powder and add them to 20kg of 1% ethylenediaminetetraacetic acid aqueous solution at 50°C. Stir at 400r / min for 2h, cool to room temperature, put it into a centrifuge, centrifuge at 8000r / min for 15min, remove the precipitate, put it in a vacuum freeze-drying oven, and dry at -20°C for 24h to obtain pearl protein. Take 500g of fresh For catfish swim bladder, remove the blood vessels and mucous membranes in the swim bladder, wash the swim bladder with deionized water for 5 times, drain the washed swim bladder, soak it in 5kg of 5% sodium carbonate solution, stir at 400r / min for 10h, take out Wash the swim bladder with deionized water until the washing liquid is neutral, air-dry it naturally, put it into a pulverizer and crush it, pass through a 60-mesh sieve to obtain a pretreated swim bladder, take 200g of the pretreated swim bl...

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Abstract

The invention relates to a nanometer bone repairing material and a preparation method thereof, and belongs to the technical field of biomedical materials. Bovine bone powder is calcined at high temperature to produce biphasic calcium phosphate in a beta-tricalcium phosphate crystal form, and with the biphasic calcium phosphate as a framework, pearl protein and fish maw collagen are crosslinked andfilled into a porous structure of the biphasic calcium phosphate, so that the brittleness and mechanical properties of the nanometer bone repairing material are improved; in the process of guiding tissue regeneration, the degradation rate of the nanometer bone repairing material is adapted to tissue growth, so that the spatial capacity of a bone defect position is maintained to prevent a fibroustissue from entering a bone defect area, and a degraded product is prevented from quickly entering a body to affect the tissue regeneration at the bone defect position; in addition, the pearl proteinis used for regulating the deposition rate and the surface morphology of CaCO3, a calcium ion binding condition is adjusted, nucleation of calcium carbonate crystals is accelerated, the alkaline phosphatase activity is promoted, osteoblast differentiation is induced, formation of mineralized nodules is promoted, osteoclast differentiation and bone tissue absorption are inhibited, and bone repair is effectively promoted.

Description

technical field [0001] The invention relates to a nanometer bone repair material and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] With the development of society, bone defects or nonunions caused by trauma, infection and tumors are increasing day by day. According to statistics, there are about 2.2 million bone defect patients every year. Bone defect is a common clinical disease, and its repair and treatment is one of the clinical problems. Bone graft surgery is usually used to treat bone defects or nonunions. Bone grafting materials mainly include autologous bone, allogeneic bone, xenograft bone and various artificial bone graft substitutes. Autologous bone has good osteoinductive activity and no immunogenicity, and is the "gold standard" of bone transplantation, but its limited source and the need for secondary surgery limit its application. The risk of disease infection and immune rejection of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/22A61L27/24A61L27/36A61L27/50A61L27/54A61L27/58
CPCA61L27/12A61L27/227A61L27/24A61L27/3608A61L27/365A61L27/50A61L27/54A61L27/58A61L2430/02C08L89/00
Inventor 李璐王文新史玉玲
Owner 常州琨瑶纺织品有限公司
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