Bone repair composite material based on acellular biological tissue matrix material and preparation method of bone repair composite material

Abstract

The invention relates to a bone repair composite material based on an acellular biological tissue matrix material and a preparation method of the bone repair composite material. According to the bone repair composite material disclosed by the invention, a micro-fibrotic animal tissue acellular matrix material is taken as an organic component, and a calcium salt biological ceramic material or other inorganic bioglass is taken as an inorganic component. According to the bone repair composite material prepared by the method disclosed by the invention, additional physical crosslinking or chemical crosslinking is not needed, and the bone repair composite material has a complete three-dimensional porous net structure; the protein component in the biological tissue matrix material has the natural triplex structure; the bone repair composite material has the excellent biocompatibility, the complete biodegradability, the excellent osteoconduction, as well as the excellent osteoinductivity and the excellent osteogenesis, also has certain mechanical strength and shape memory function, and can be used as a bone filling material with bioactivity or a repair material for large-area bone defect.

Description

technical field [0001] The invention belongs to the field of material science, and in particular relates to a composite material for bone repair based on an acellular biological tissue matrix material and a preparation method thereof. The composite material can be widely used in the fields of orthopedics and plastic surgery. Background technique [0002] The repair and reconstruction of damaged bone tissue is an important task for orthopedic surgeons worldwide. According to statistics, in 2013, more than 600,000 bone graft operations were performed in China and 1 million cases in the United States. Material sales exceeded $2 billion. Repairing damaged bone tissue requires the use of bone graft materials, and the gold standard for repairing damaged bone tissue worldwide is human autologous bone tissue, that is, healthy bone tissue taken from the patient itself. Autologous bone has all the properties needed to repair bone tissue, such as excellent osteoinductivity, osteocondu...

AI Technical Summary

Problems solved by technology

The disadvantage of chemically purified collagen is that the extraction process is complicated. At the same time, collagen is denatured during the extraction process and loses its inherent triple helical structure, resulting in the loss of its original biological properties. In addition, collagen is extracted from biological tissues by chemical methods. Protein leads to the loss of various organic components in the original biological matrix in the final material, resulting in a relatively single component that cannot meet the complex signaling pathway requirements in the bone repair process; at the same time, chemically purified collagen is generally used as bone repair materials. It is necessary to use toxic chemical cross-linking agents such as formaldehyde, 2,3-dihydroxypropionaldehyde, glutaraldehyde, or carbodiimide to cross-link the collagen molecular chains to improve the strength and thermal stability of collagen However, when the chemically cross-linked collagen is degraded and absorbed after the material is implanted in the body, it will produce toxic cross-linking agent small molecules, which will produce cytotoxicity and cause inflammation and immune response

Images