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Preparation method and application of nano mesoporous silica doped hydrogel drug controlled-release carrier material

A silica and nano-mesoporous technology, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of low bioavailability, poor solubility of IDM, poor fat solubility, etc., and achieve good relief release effect, drug leakage improvement, and mild preparation conditions

Inactive Publication Date: 2018-04-03
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of protein drugs (such as bovine serum albumin BSA) in the oral drug delivery system mainly faces two problems: one is that pepsin has a strong hydrolysis effect on protein and polypeptide drugs, and the drugs are easily destroyed, resulting in a decline in their effect; Second, due to the large molecular weight and poor fat solubility of protein and polypeptide drugs, it is difficult to pass through the intestinal mucosa, so the permeability to the intestinal mucosa is low
However, IDM has obvious damage to the gastrointestinal tract, and the incidence rate of adverse reactions (ADRs) after long-term use is higher, and its side effects on the gastrointestinal tract and central nervous system can reach 35%-50%. associated with high blood levels
On the other hand, IDM has poor solubility and low bioavailability in common formulations such as tablets, capsules, etc.

Method used

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  • Preparation method and application of nano mesoporous silica doped hydrogel drug controlled-release carrier material
  • Preparation method and application of nano mesoporous silica doped hydrogel drug controlled-release carrier material
  • Preparation method and application of nano mesoporous silica doped hydrogel drug controlled-release carrier material

Examples

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Effect test

Embodiment 1

[0049] Example 1: A preparation method of a hydrogel drug sustained-release carrier material doped with nanometer mesoporous silica

[0050] Weigh 0.1g of MSN into a volumetric flask filled with 25mL of deionized water, ultrasonically disperse for 1h, and prepare a 0.4% MSN solution. Pipette 10mL of the above MSN solution, add 0.4g gelatin to the solution, first perform limited swelling for 30min, then heat in a water bath at 40°C, stir until the gelatin dissolves, and prepare a 4% gelatin solution. Weigh 0.3 g of sodium alginate powder into another round-bottomed flask containing 10 mL of the above-mentioned MSN solution, stir at room temperature until dissolved, and prepare a 3% sodium alginate solution. Take 10mL of the prepared gelatin solution and 10mL of the prepared sodium alginate solution to prepare a 1:1 mixed solution, stir in a water bath at 40°C, and use a vacuum pump to evenly degas until there are no bubbles, then use the artificial drop method. Slowly drop the...

Embodiment 2

[0052] Example 2: A preparation method of a hydrogel drug sustained-release carrier material doped with nanometer mesoporous silica

[0053] Weigh 0.1g of MSN into a volumetric flask filled with 25mL of deionized water, disperse by ultrasonication for 1h, and prepare a 0.4% MSN solution. Pipette 10mL of MSN solution, add 0.4g of gelatin to the solution, perform limited swelling for 30min, then heat in a water bath at 40°C, stir until the gelatin dissolves, and prepare a 4% gelatin solution. Weigh 0.3 g of sodium alginate powder into another round-bottomed flask containing 10 mL of the above-mentioned MSN solution, stir at room temperature until dissolved, and prepare a 3% sodium alginate solution. Take 10mL of the prepared gelatin solution and 10mL of the prepared sodium alginate solution to prepare a 1:1 mixed solution, stir in a water bath at 40°C, and use a vacuum pump to evenly degas until there are no bubbles, then use the artificial drop method. Slowly drop the mixed so...

Embodiment 3

[0055] Example 3: A preparation method of a slow-release drug-loaded hydrogel

[0056] Take 0.25g BSA, dilute it to 25mL with deionized water, and prepare a 10mg / mL BSA solution; add 0.1g MSN to the BSA solution, disperse ultrasonically until the MSN is completely dispersed, and prepare a 0.4% MSN solution. Take 10mL of the above MSN solution and add 0.4g of gelatin, perform limited swelling for 30 minutes, then heat in a water bath at 40°C, stir until the gelatin dissolves, and prepare a 4% gelatin solution. Take another 10 mL of MSN solution, add 0.3 g of sodium alginate powder, stir and dissolve at room temperature, and prepare a 3% sodium alginate solution. Take 10mL of the prepared gelatin solution and 10mL of the prepared sodium alginate solution to form a 1:1 mixed solution, stir in a water bath at 40°C, and degas evenly with a vacuum pump, then use the manual drop method to slowly dissolve the mixed solution at room temperature. Add dropwise 400mL of 2% CaCl 2 In the...

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Abstract

The invention belongs to the field of drug controlled-release carrier materials, and in particular discloses a preparation method and an application of a nano mesoporous silica doped hydrogel drug controlled-release carrier material. With gelatin GE, sodium alginate SA and nano mesoporous silica MSN as raw materials, firstly, a GE-SA semi-interpenetrating composite gel, which contains the MSN, isprepared by virtue of a Ca2+ physical cross-linking method; and then, polymer electrolyte membrane modifying is conducted on the hydrogel by virtue of chitosan CS, so that a stable GE-SA-CS (MSN) composite gel is obtained. A controlled-release effect of the composite hydrogel material on drugs is investigated by taking BSA, MH and IDM as model drugs. The composite hydrogel system, on the basis ofthe effective utilization of a drug 'warehousing' effect of the nano mesoporous silica, can obviously improve the drug loading capacity and encapsulation efficiency of the BSA, MH and IDM, and the composite hydrogel system and remarkably enhance the controlled-release effects of the BSA and the IDM. The hydrogel is gentle in preparation conditions, simple and convenient in method, natural in materials and free from sharp reactions, and the hydrogel is a novel pH-sensitive composite hydrogel drug controlled-release system having a broad application prospect.

Description

technical field [0001] The invention relates to the field of drug slow-release carrier materials, in particular to a preparation method and application of a hydrogel drug slow-release carrier material mixed with mesoporous silica. Background technique [0002] Hydrogel (Hydrogel) is a polymer network system with a network cross-linked structure using water as the dispersion medium. It is soft in nature, can maintain a certain shape, and absorb a large amount of water. A smart hydrogel is a hydrogel that responds to changes in the surrounding environment (such as pH, temperature, light, and ionic strength), and can also be called a stimulus-responsive-sensitive gel. Because it can absorb a large amount of water and swell significantly in water, it can continue to maintain its original structure without dissolving after swelling, and it can also respond to slight changes in the external environment (such as temperature, pH, ionic strength, electric field, magnetic field, etc.)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/04A61K47/36A61K47/42A61K38/38A61K31/405A61K31/155
CPCA61K9/0002A61K9/06A61K31/155A61K31/405A61K38/385A61K47/02A61K47/36A61K47/42
Inventor 胡燕吴丹丹董晓莹肖新才
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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