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A film-covered Y-shaped bile duct stent partially covered with chemotherapeutic drugs

A chemotherapy drug and bile duct stent technology, which is applied in the field of medical devices, can solve the problems that chemotherapy drugs cannot reach, chemotherapy lacks slow-release effect, etc., and achieve the effects of easy popularization, prolonging the usual time, and high technical success rate

Active Publication Date: 2020-04-14
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a film-covered Y-shaped biliary stent partially covered with chemotherapy drugs, which solves the lack of slow-release effect of chemotherapy in the prior art, and the instantaneous concentration of the body is too high after absorption, and then drops rapidly. The problem of not being able to reach a relatively stable level

Method used

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  • A film-covered Y-shaped bile duct stent partially covered with chemotherapeutic drugs
  • A film-covered Y-shaped bile duct stent partially covered with chemotherapeutic drugs
  • A film-covered Y-shaped bile duct stent partially covered with chemotherapeutic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] One, antitumor active substance is made nanoparticle solution and comprises the following steps:

[0042] (1) Each component is weighed according to the following mass ratio: the ratio of antitumor active substance, methylcellulose and water is 0.1:0.1:100;

[0043] (2) Stir and mix the methylcellulose and water weighed in (1) under 400W ultrasonic power to fully dissolve the methylcellulose, then add the weighed anti-tumor active substance, and continue to ultrasonically stir under 400W power , the fully mixed mixed solution was put into a dialysis bag with a molecular weight cut-off of 6000 Da, dialyzed for 24 hours, collected the solution in the dialysis bag, concentrated under reduced pressure until the volume was reduced by 5 times, and obtained a nanoparticle solution.

[0044] 2. The preparation steps of the chemotherapeutic drug coating 4 are as follows:

[0045] Weigh starch and polyvinylpyrrolidone according to a mass ratio of 1:2, stir and mix to obtain a dr...

Embodiment 2

[0050] One, antitumor active substance is made nanoparticle solution and comprises the following steps:

[0051] (1) Each component is weighed according to the following mass ratio: the ratio of antitumor active substance, methylcellulose and water is 1:1:100;

[0052] (2) Stir and mix the methylcellulose and water weighed in (1) under 400W ultrasonic power to fully dissolve the methylcellulose, then add the weighed anti-tumor active substance, and continue to ultrasonically stir under 400W power , the fully mixed mixed solution was put into a dialysis bag with a molecular weight cut-off of 6000 Da, dialyzed for 72 hours, collected the solution in the dialysis bag, concentrated under reduced pressure to reduce the volume by 5 times, and obtained a nanoparticle solution.

[0053] 2. The preparation steps of the chemotherapeutic drug coating 4 are as follows:

[0054] Weigh starch and polyvinylpyrrolidone according to a mass ratio of 1:3, stir and mix to obtain a drug carrier; ...

Embodiment 3

[0060] The anti-tumor active substance is made of the following components by weight: 10 parts of Angelica sinensis, 10 parts of Rhizoma Chuanxiong, 20 parts of Tianqi, 30 parts of Maca;

[0061] The antitumor active substance is made according to the following method:

[0062] Weigh each component according to the following parts by weight: 10 parts of Angelica sinensis, 10 parts of Rhizoma Chuanxiong, 20 parts of Tianqi, 30 parts of Maca;

[0063] Grind the weighed Angelica, Rhizoma Chuanxiong, Tianqi and Maca respectively, mix them thoroughly, pass through a 40-mesh sieve, and conduct countercurrent extraction with supercritical carbon dioxide circulation for 2 hours, the extraction pressure is 35Mpa, and the extraction temperature is 50°C to obtain the extract;

[0064] Concentrate the extract under reduced pressure until the relative density of the solution is 1.2 to obtain a mixed concentrate;

[0065] The mixed concentrate is spray-dried to obtain the dry powder of the...

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Abstract

The invention belongs to the technical field of medical instruments, and specifically discloses a film-covering-type Y-shaped bile duct stent partially covered with chemotherapeutic drugs. The stent includes a parent stent and a branch stent, and the parent stent is of a bent net-shaped cavity structure; the bent position of the parent stent is provided with a connecting port, and the branch stent is connected in a matching mode with the connecting port of the parent stent; the duct wall, except the connecting port, of the middle of the parent stent and the outer wall of the branch stent are both provided with two layers of chemotherapeutic drug covering films; antitumor bioactive substances are made into a nanoparticle solution and then mixed with a drug carrier to obtain the chemotherapeutic drugs, the chemotherapeutic drugs are sprayed to covering films covered with a glycerinum-gelatin layer, and then the chemotherapeutic drug covering films are obtained; moreover, the chemotherapeutic drugs are clamped in a connection mode between two layers of chemotherapeutic drug covering films. According to the bile duct stent, after the bile duct stent is released and installed in a bile duct, the chemotherapeutic drugs on the chemotherapeutic drug covering films are gradually released in a permeation mode, and the phenomenon of exorbitant instantaneous drug concentration cannot be caused.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a film-covered Y-shaped bile duct stent partially covered with chemotherapeutic drugs. Background technique [0002] Cholangiocarcinoma (cholangiocarcinoma) refers to malignant tumors originating from the bile duct epithelium. The onset of the disease is often hidden, and the clinical symptoms are often atypical. In addition, the lack of understanding of the disease in the past and the hidden location of the tumor growth make early diagnosis extremely difficult. Progressive jaundice is the main manifestation, and it is late when the patient sees a doctor. The tumor is large, complicated in location, tumor infiltrated, and the surgical treatment is complicated. It cannot be done, and the long-term effect is not ideal, and the 5-year survival rate is 5-15%. [0003] Palliative biliary drainage tube implantation or biliary stent implantation is often used for patients with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/00A61L31/10A61L31/08A61L31/14A61K36/31A61P35/00
CPCA61K36/23A61K36/232A61K36/236A61K36/258A61K36/31A61L31/005A61L31/08A61L31/10A61L31/146A61L31/16A61L2300/30A61L2300/416A61L2300/602C08L89/00A61K2300/00
Inventor 焦德超韩新巍李宗明任克伟水少锋韩冰王艳丽周朋利
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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