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3D printed sodium alginate-collagen type I-ceramic composite scaffold and preparation method and application thereof

A sodium alginate and 3D printing technology, which is applied in medical science, prosthesis, additive processing, etc., can solve problems such as the inability to bear the huge stress of the knee joint, poor mechanical properties of fibrocartilage, and the inability to guarantee long-term curative effect, etc., to achieve improved Chondrocyte proliferation and ALP activity, reduce chronic inflammatory response, and facilitate cell adhesion

Active Publication Date: 2017-11-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current clinical treatment methods such as microfracture, osteochondral column transplantation, and chondrocyte transplantation do not involve combined treatment of osteochondral injury, and the new cartilage tissue is often fibrocartilage rather than hyaline cartilage.
Fibrocartilage has poor mechanical properties and cannot withstand the huge stress generated by the daily activities of the knee joint, and is prone to degeneration and wear, so long-term efficacy cannot be guaranteed

Method used

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  • 3D printed sodium alginate-collagen type I-ceramic composite scaffold and preparation method and application thereof
  • 3D printed sodium alginate-collagen type I-ceramic composite scaffold and preparation method and application thereof
  • 3D printed sodium alginate-collagen type I-ceramic composite scaffold and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0038] 1) after the calcium magnesium silicate powder is processed by wet ball milling, the ultrafine powder with particle size not exceeding 5 μm is obtained, the ultrafine powder is dispersed in deionized water, and stirred at normal temperature for 1 hour, and then 1 The collagen powder was stirred at room temperature for 5 minutes, and finally sodium alginate was added and stirred at room temperature for 15 minutes to make a hydrogel as a composite ink;

[0039] The mass fraction ratio of sodium alginate: collagen type I: calcium magnesium silicate is 6:2:5.

[0040] The calcium magnesium silicate is magnesium-doped wollastonite, and the molar percentage of magnesium replacing calcium in the magnesium-doped wollastonite is 10%.

[0041] 2) The hydrogel is placed in a three-dimensional printer and printed using a three-dimensional printer device. The length of the scaffold was 10 mm, the pore size was 300 μm, and the porosity was 43%. During the printing process, 10% calc...

Embodiment 2

[0044] 1) After the β-tricalcium phosphate powder is processed by wet ball milling, an ultrafine powder with a particle size of no more than 5 μm is obtained, the ultrafine powder is dispersed in deionized water, and stirred for 1 hour at normal temperature, and then 1 The collagen powder was stirred at room temperature for 5 minutes, and finally sodium alginate was added and stirred at room temperature for 15 minutes to make a hydrogel as a composite ink;

[0045] The mass fraction ratio of sodium alginate: collagen type I: β-tricalcium phosphate was 6:2:5.

[0046] 2) The hydrogel is placed in a three-dimensional printer and printed using a three-dimensional printer device. The length of the scaffold was 10 mm, the pore size was 300 μm, and the porosity was 43%. During the printing process, 10% calcium chloride was used for spray crosslinking. After printing, the scaffold was soaked in a 10% calcium chloride solution for 10 minutes for further crosslinking to obtain the fin...

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Abstract

The invention discloses a 3D printed sodium alginate-collagen type I-ceramic composite scaffold and a preparation method and application thereof. The composite scaffold is mainly composed of sodium alginate, collagen type I and calcium magnesium silicate according to a mass ratio of (1-6): 2: (0-10) and utilizes calcium chloride as a crosslinking agent, wherein a mass fraction of calcium chloride in the composite scaffold is 1 to 10%. The preparation method comprises dispersing the calcium magnesium silicate powder in deionized water, fully mixing the solution, compounding the solution, collagen type I and sodium alginate to obtain uniform hydrogel, placing the hydrogel in a 3D printer, carrying out crosslinking with calcium chloride and printing a porous scaffold which is the composite scaffold. The composite scaffold can promote chondrocyte proliferation and ALP activity, has excellent biological activity and has an application value in tissue engineering.

Description

technical field [0001] The invention relates to medical biological materials, in particular to a 3D printed sodium alginate-type I collagen-ceramic composite stent, a preparation method and an application. technical background [0002] Cartilage defects are a common disease in orthopaedics, especially in athletes, and cartilage damage is often combined with subchondral bone damage. Patients often suffer from joint swelling, pain, and limited activities, which affect daily life and work, and cause a greater economic burden to the society. Cartilage has no blood vessels, no nerves, and no lymph nodes. It has poor self-repair ability after injury, and is difficult to treat. It has always been a problem for orthopaedics. However, the current clinical treatment methods such as microfracture, osteochondral column transplantation, chondrocyte transplantation, etc. do not involve the combined treatment of osteochondral injury, and the newly formed cartilage tissue is often fibrocar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/20A61L27/10A61L27/56A61L27/50B33Y70/00B33Y80/00
CPCA61L27/10A61L27/20A61L27/24A61L27/50A61L27/56A61L2430/06B33Y70/00B33Y80/00C08L5/04
Inventor 余新宁戴雪松苟中入杨贤燕沈炜亮赵腾飞方晶华
Owner ZHEJIANG UNIV
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