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Synthesis method of hollow mesoporous silicon dioxide nano-drug capsule

A technology of mesoporous silica and nano-drugs, which is applied in the direction of drug combination, capsule delivery, microcapsules, etc., can solve the problems of shortened storage time of nano-drugs, cumbersome process, and reduced drug efficacy, and achieve the goal of increasing polyethylene glycol diuretics. The effect of the amount of acrylate, good biocompatibility, and improved densification

Inactive Publication Date: 2017-05-10
XINYANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although hollow mesoporous silica nanoparticles are very suitable as nano-drug carriers, how to use hollow mesoporous silica nanoparticles to realize the loading and encapsulation of drugs is still a challenge. The current way is to use van der Waals force Carry out drug loading directly instead of surface encapsulation (Small, 2010, 6, 471-478; ACS Nano, 2008, 2, 889-896), and the surface of hollow mesoporous silica nanoparticles does not Encapsulation will cause drug leakage, resulting in shortened storage time and reduced drug efficacy of nano-medicines; another way to synthesize nano-medicines is to encapsulate hollow mesoporous silica nanoparticles through surface modification (J. Am. Chem. Soc., 2011,133, 8778- 8781; Angew. Chem. Int. Ed. Engl., 2013, 52, 5580-5584), this encapsulation method needs multi-step reaction, the process is cumbersome, and because the loading The mesoporous silica after the drug is separated from the drug solution. This process will also cause drug leakage, so further improvements to the existing technology are needed

Method used

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  • Synthesis method of hollow mesoporous silicon dioxide nano-drug capsule
  • Synthesis method of hollow mesoporous silicon dioxide nano-drug capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A method for synthesizing hollow mesoporous silica nanomedicine capsules loaded with gemcitabine hydrochloride includes the following steps:

[0026] (1) 50 mg of hollow mesoporous silica nanoparticles with a particle size of 500 nm were sonicated at a frequency of 40 kHz for 20 minutes, dispersed in 50 mL of absolute ethanol, and then 5 mL of ammonia and 500 mg of 3-(trimethyl) were added. (Oxysilyl) propyl methacrylate, the reaction was stirred for 8 h at 500 rpm at 35 °C; then centrifuged at 12000 rpm for 15 min, and the centrifuged precipitate was sonicated at 40 kHz for 20 min. Dispersed in 20 mL of 1 × PBS buffer, and centrifuged at 12000 rpm for 15 min to remove residual ethanol, and obtain the precipitation of hollow mesoporous silica nanoparticles with surface modified propyl acrylate groups.

[0027] (2) Dissolve 300 mg of gemcitabine hydrochloride in 50 mL of 1 × PBS buffer, and then add the hollow mesoporous silica nanoparticles with surface modified propyl acryl...

Embodiment 2

[0030] A method for synthesizing hollow mesoporous silica nano-medicine capsules loaded with doxorubicin hydrochloride includes the following steps:

[0031] (1) 10 mg of hollow mesoporous silica nanoparticles with a particle size of 300 nm were sonicated at 40 kHz for 20 min, and dispersed in 10 mL of absolute ethanol, and then 0.4 mL of ammonia and 100 mg of 3-(trimethoxy) (Silyl) propyl methacrylate, stirred for 8 h at 500 rpm at 30 °C; then centrifuged at 12000 rpm for 15 min, the centrifuged precipitate was sonicated at 40 kHz for 20 min, and dispersed in In 20 mL of 1 × PBS buffer, centrifuge at 12000 rpm for 15 minutes to remove residual ethanol. The hollow mesoporous silica nanoparticles with surface modified propyl acrylate groups are precipitated.

[0032] (2) Dissolve 100 mg of doxorubicin hydrochloride in 10 mL of 1 × PBS buffer, and then add the hollow mesoporous silica nanoparticles with surface modified propyl acrylate groups obtained in step (1) to precipitate at 4...

Embodiment 3

[0036] A method for synthesizing cisplatin-loaded hollow mesoporous silica nano-medicine capsules includes the following steps:

[0037] (1) 20 mg of hollow mesoporous silica nanoparticles with a particle size of 300 nm were sonicated at 40 kHz for 20 min, dispersed in 20 mL of absolute ethanol, and then 0.4 mL of ammonia and 200 mg of 3-(trimethoxy (Silyl) propyl methacrylate, stirred for 4 h at 500 rpm at 30 °C; then centrifuged at 12000 rpm for 15 min, and the centrifuged precipitate was sonicated at 40 kHz for 20 min and dispersed in In 20 mL of 1 × PBS buffer, centrifuge at 12000 rpm for 15 minutes to remove residual ethanol. The hollow mesoporous silica nanoparticles with surface modified propyl acrylate groups are precipitated.

[0038] (2) Dissolve 40 mg of cisplatin in 20 mL of 1 × PBS buffer, and add the hollow mesoporous silica nanoparticles with surface modified propyl acrylate groups obtained in step (1) to precipitate at a frequency of 40 kHz Disperse ultrasonically...

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Abstract

The invention belongs to the field of nano-drugs, and particularly relates to a synthesis method of a hollow mesoporous silicon dioxide nano-drug capsule. The synthesis method comprises the following steps: modifying hollow mesoporous silicon dioxide through an acrylic acid propyl ester group, dispersing the hollow mesoporous silicon dioxide into a drug-containing buffer solution, then adding polyethylene glycol diacrylate and ammonium persulfate serving as an initiator, and dripping N,N,N',N'-tetramethylethylenediamine serving as an accelerator to enable the polyethylene glycol diacrylate and the acrylic acid propyl ester group to generate polymerization reaction on the surface of the hollow mesoporous silicon dioxide to form a polymer coated layer. Loading of a drug and encapsulation of a nano capsule are completed in the drug-containing buffer solution, so that leakage of the drug in an encapsulation process can be avoided; the synthesis process is simple, and the coating thickness and the compactness can be adjusted.

Description

Technical field [0001] The invention belongs to the field of nano medicines, and specifically relates to a method for synthesizing hollow mesoporous silica nano medicine capsules. Background technique [0002] The development of nanotechnology in biomedicine has given birth to nanomedicine, which is to prepare drugs and excipients into nano-drug-loaded particles with a particle size in the range of 1-100 nm and construct a nano-drug delivery system. The emergence of nano-medicine has solved many traditional problems in the medical field. Compared with traditional drugs, nano-drug delivery can improve the stability and metabolic kinetics of the drug, and can greatly improve the efficacy and reduce side effects through targeted delivery to the lesion tissue. Currently, the most researched nano-drug carriers include liposomes, polymer micelles, serum proteins, gold nanoparticles and mesoporous silica. Among them, mesoporous silica has the characteristics of orderly and adjustable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/14A61K31/704A61K33/24A61K31/7068A61P35/00
CPCA61K9/5115A61K9/5146A61K31/704A61K31/7068A61K33/24
Inventor 朱祥龙师赛鸽卢先春许春萱
Owner XINYANG NORMAL UNIVERSITY
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