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Antibacterial fibroin-based bionic coating and preparation method thereof

A technology of antibacterial silk and silk protein, applied in coatings, pharmaceutical formulations, medical science, etc., to achieve the effects of no thrombus formation, good biocompatibility, and high bonding strength

Inactive Publication Date: 2017-04-26
苏州纳贝通环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a bioactive metal implant coating with antibacterial, wear-resistant, strong binding force and corrosion resistance and its preparation method to solve at least one technical problem in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An antibacterial silk protein-based biomimetic coating, prepared from the following raw materials in parts by weight: 14 parts of silk protein, 3 parts of caffeic acid dopamine, 4 parts of dopamine hydrochloride, 1 part of chitosan fiber, 1 part of polyurethane, and 1.4 parts of boric acid , 0.8 parts of calcium metaphosphate, 1 part of strontium fluorophosphate, 3 parts of seaweed extract, 0.8 parts of luteolin, 1.3 parts of puffball powder, 0.8 parts of zinc oxide, 1.5 parts of strontium gluconate, 0.6 parts of glycine fumarate, Potassium hydroxide 0.6 parts, polyvinyl alcohol 1.6 parts, distilled water 20 parts, salicylic acid ethylene glycol 5 parts, ethanol 40 parts.

[0025] The silk protein is degummed silk protein.

[0026] The solid content of the seaweed extract is 10%, and the advanced steps of the seaweed extract are: chop the seaweed, add water and boil for 15 minutes, then transfer to 30 times the weight of sodium pyrophosphate solution, and ultrasonically...

Embodiment 2

[0035] An antibacterial silk protein-based biomimetic coating, prepared from the following raw materials in parts by weight: 22 parts of silk protein, 9 parts of caffeic acid dopamine, 7 parts of dopamine hydrochloride, 6 parts of chitosan fiber, 4 parts of polyurethane, and 3.7 parts of boric acid , 3.6 parts of calcium metaphosphate, 4 parts of strontium fluorophosphate, 6 parts of seaweed extract, 2.5 parts of luteolin, 4 parts of puffball powder, 2.2 parts of zinc oxide, 3.1 parts of strontium gluconate, 2.5 parts of glycine fumarate, Potassium hydroxide 1.5 parts, polyvinyl alcohol 4 parts, distilled water 32 parts, salicylic acid ethylene glycol 12 parts, ethanol 60 parts.

[0036] The silk protein is moth silk degummed silk protein.

[0037] The solid content of the seaweed extract is 20%, and the advanced steps of the seaweed extract are: chop the seaweed, add water and boil for 15 minutes, then transfer to 30 times the weight of sodium pyrophosphate solution, and ultr...

Embodiment 3

[0046] An antibacterial silk protein-based biomimetic coating, prepared from the following raw materials in parts by weight: 16 parts of silk protein, 3.5 parts of caffeic acid dopamine, 4.6 parts of dopamine hydrochloride, 1.8 parts of chitosan fiber, 1.6 parts of polyurethane, and 1.6 parts of boric acid , 0.9 parts of calcium metaphosphate, 1.6 parts of strontium fluorophosphate, 3.4 parts of seaweed extract, 1.1 parts of luteolin, 1.4 parts of puff powder, 1.1 parts of zinc oxide, 1.7 parts of strontium gluconate, 0.8 parts of glycine fumarate, Potassium hydroxide 0.7 parts, polyvinyl alcohol 1.8 parts, distilled water 24 parts, salicylic acid ethylene glycol 7 parts, ethanol 48 parts.

[0047] The silk protein is moth silk degummed silk protein.

[0048] The solid content of the seaweed extract is 15%, and the advance steps of the seaweed extract are: chop the seaweed, add water and boil for 15 minutes, then transfer to 30 times the weight of sodium pyrophosphate solution...

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PUM

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Abstract

The invention discloses an antibacterial fibroin-based bionic coating and a preparation method thereof. The bionic coating is prepared from the following raw materials: fibroin, caffeic acid dopamine, dopamine hydrochloride, chitosan fibers, polyurethane, boric acid, calcium metaphosphate, strontium fluorapatite, a seaweed extract, galuteolin, puffball powder, zinc oxide, strontium gluconate, glycine fumarate, potassium hydroxide, polyvinyl alcohol, distilled water, glycol salicylate and ethanol. The bionic coating provided by the invention is high in bonding intensity with a metal implant, low in coefficient of wear on a steel ball and excellent in wear resistance, and the bionic coating is excellent in antibacterial effect on staphylococcus aureus; and meanwhile, the bionic coating is good in biocompatibility, free from cell toxicity, free from formation of blood coagulation and thrombosis and free from any inflammatory reaction, and the bionic coating has a good clinical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an antibacterial silk protein-based bionic coating and a preparation method thereof. Background technique [0002] Medical metal implants have high mechanical strength and fatigue resistance, and are currently one of the most widely used medical materials in clinical practice. Common medical metal implants include vascular stent materials, artificial prosthetics, artificial bone joints, and internal fixation items in the human body, which are mainly made of implant materials such as cobalt alloy, titanium alloy, and stainless steel. However, the biocompatibility of most metal implants is not good, and the corrosion resistance in human body fluids is poor, and metal ions are easily precipitated, causing toxic and side effects in surrounding tissues and seriously affecting the therapeutic effect. Coating modification on the surface of metal implants is one...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/34A61L27/32A61L27/30A61L27/54C25D11/02
CPCA61L27/34A61L27/306A61L27/32A61L27/3637A61L27/50A61L27/54A61L2300/404A61L2400/18C25D11/02
Inventor 潘明华
Owner 苏州纳贝通环境科技有限公司
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