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Medical drug-loaded metal-macromolecular gradient porous composite

A polymer material, gradient porous technology, used in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low mechanical properties of porous materials, insufficient for bone implantation, etc., and achieve excellent mechanical properties, shape and size easily. Control, the effect of low manufacturing cost

Inactive Publication Date: 2017-01-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the mechanical properties of porous materials are low, which is not enough for the application of bone implants under mechanical loads.

Method used

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  • Medical drug-loaded metal-macromolecular gradient porous composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Medical-grade titanium wire with a diameter of 0.05mm is used, which is wound and woven into a set shape with a porosity of 90%. The molten polyether ether ketone is injected into the pores of porous titanium by pressure casting, and then passed through the 10% concentration Hydrofluoric acid was corroded for 5 minutes to form a gradient porous titanium-polyether ether ketone composite material with a surface porous layer of 2%. The material has a compressive yield strength of 130MPa and an elastic modulus of 25GPa, which is suitable for bone repair under stress loading and bone implants.

Embodiment 2

[0029] Medical-grade titanium wire with a diameter of 0.2mm is used, which is wound and woven into a set shape with a porosity of 70%. The molten polyether ether ketone is injected into the pores of porous titanium by pressure casting, and then passed through a concentration of 10%. Hydrofluoric acid was etched for 15 minutes to form a gradient porous titanium-polyether ether ketone composite material with a surface porous layer of 10%. The surface porous layer is loaded with tantalum powder by laser cladding. Tantalum has excellent biocompatibility and can effectively improve the osseointegration ability of the material. The material has a compressive yield strength of 150MPa and an elastic modulus of 30GPa, making it suitable for bone repair and bone implantation under stressed load conditions.

Embodiment 3

[0031] Medical-grade titanium wire with a diameter of 0.4mm is used, which is wound and woven into a set shape with a porosity of 50%. The molten polyether ether ketone is injected into the pores of porous titanium by pressure casting, and then passed through a concentration of 10%. Hydrofluoric acid was etched for 30 minutes to form a gradient porous titanium-polyether ether ketone composite material with a surface porous layer of 20%. The hydroxyapatite slurry is loaded into the surface pores and then cured. The hydroxyapatite has excellent biocompatibility and can promote the formation of a firm bond between the implant and the bone. The material has a compressive yield strength of 140MPa and an elastic modulus of 32GPa, making it suitable for bone repair and bone implantation under stress loading.

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Abstract

The invention relates to a medical drug-loaded metal-macromolecular gradient porous composite. A medical polymer material is adopted as a matrix of the metal-macromolecular gradient porous composite, and a porous material woven from medical metal wires in a wound mode is adopted as a wild phase, wherein the volume fraction of the matrix ranges from 10% to 90%; according to the metal-macromolecular gradient porous composite, the matrix is extruded into a hole of the wild phase, then part of wild phase metal is removed through a chemical corrosion method, and the gradient porous material with a porous surface and a solid interior is formed. Compared with the prior art, the material has the excellent mechanical property and good bone transmission and inducing capacity, and the surface layer porous layer thickness, the pore size and porosity can be controlled. Drugs can be loaded into the surface layer porous layer according to needs, and the functions of preventing infection and promoting bone growth and healing are achieved. A preparation method has the advantages of being easy to operate and practicable, low in cost and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a medical drug-loadable metal-polymer gradient porous composite material, and the prepared material is mainly used in bone repair and bone transplantation. Background technique [0002] Medical polymer materials have good mechanical properties, chemical stability and other characteristics. Therefore, medical polymer materials have been widely used in clinical applications. However, medical polymer materials generally have poor biological activity, and it is difficult to form bone fusion with human bones, which limits their application as bone repair materials. Pores in medical materials can provide channels for bone cell growth and body fluid transport, which is conducive to the combination of materials and bone cells. However, the mechanical properties of porous materials are low, which is not enough for bone implants under mechanical loads. Therefore, it is of great signi...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/44A61L27/56A61L27/54
CPCA61L27/46A61L27/443A61L27/446A61L27/54A61L27/56A61L2430/02A61L2430/24
Inventor 何国李秋炎
Owner SHANGHAI JIAO TONG UNIV
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