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Preparation method of dental implant and composite surface thereof

A dental implant, titanium-based technology, applied in the direction of prosthesis, medical science, pharmaceutical formulations, etc., can solve the problems of reinforcement, low bonding strength of modified coating, complicated preparation process, etc., to achieve enhanced adhesion and spreading, and improve the surface Hydrophilicity, effects of improving stability and success rate

Inactive Publication Date: 2016-08-31
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of low bonding strength and complex preparation process of existing dental implant surface modification coatings, and further improve the biological activity of the implant surface, the purpose of the present invention is to provide a dental implant with a bioactive composite surface grown in situ body and its preparation method, so that it can be applied to any shape of the surface, enhance the bonding strength of the film layer and the matrix, and achieve a bionic effect, strengthen the adhesion and spreading of osteoblasts on the implant surface, the activity of alkaline phosphatase, and accelerate the early stage of the implant. The speed of osseointegration realizes the firm combination of the material and the biological interface, thereby improving the stability and success rate of the implant

Method used

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  • Preparation method of dental implant and composite surface thereof
  • Preparation method of dental implant and composite surface thereof
  • Preparation method of dental implant and composite surface thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A dental implant whose surface is treated by the following methods:

[0024] (1) Select medical pure titanium as the substrate, and perform surface cleaning: acetone, absolute ethanol, and deionized water are ultrasonically cleaned for 15 minutes each, and dried naturally;

[0025] (2) Configure anodic oxidation electrolyte: use deionized water as the solvent and configure 1 mol / L sulfuric acid solution;

[0026] (3) Preparation of uniform nanoporous titanium dioxide film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, pure titanium dental implant as anode, graphite electrode or platinum electrode as cathode, put it into the electrolyte configured in the previous step; The working voltage is 150V, the oxidation time is 1 minute, the reaction temperature is room temperature, and then rinsed in deionized water and dried naturally;

[0027] (4) Precursor solution for self-polymerization of dopamine: deionized water is used as th...

Embodiment 2

[0039] A dental implant whose surface is treated by the following methods:

[0040] (1) Select medical pure titanium as the substrate, and perform surface cleaning: acetone, absolute ethanol, and deionized water are ultrasonically cleaned for 15 minutes each, and dried naturally;

[0041] (2) Configure anodic oxidation electrolyte: use deionized water as the solvent and configure 1 mol / L sulfuric acid solution;

[0042] (3) Preparation of uniform nanoporous titanium dioxide film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, pure titanium dental implant as anode, graphite electrode or platinum electrode as cathode, put it into the electrolyte configured in the previous step; The working voltage is 150V, the oxidation time is 1 minute, the reaction temperature is room temperature, and then rinsed in deionized water and dried naturally;

[0043] (4) Precursor solution for self-polymerization of dopamine: deionized water is used as th...

Embodiment 3

[0049] A dental implant whose surface is treated by the following methods:

[0050] (1) Select medical pure titanium as the substrate, and perform surface cleaning: acetone, absolute ethanol, and deionized water are ultrasonically cleaned for 15 minutes each, and dried naturally;

[0051] (2) Configure anodic oxidation electrolyte: use deionized water as the solvent and configure 1 mol / L sulfuric acid solution;

[0052] (3) Preparation of uniform nanoporous titanium dioxide film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, pure titanium dental implant as anode, graphite electrode or platinum electrode as cathode, put it into the electrolyte configured in the previous step; The working voltage is 100V, the oxidation time is 3 minutes, the reaction temperature is room temperature, and then rinsed in deionized water and dried naturally;

[0053] (4) Precursor solution for self-polymerization of dopamine: deionized water is used as t...

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Abstract

The invention relates to a preparation method of a dental implant and a composite surface thereof. In the dental implant, medical titanium or titanium alloy is used as a substrate, and porous morphology is prepared on the surface while polydopamine and hydroxyapatite are deposited to obtain a dental implant composite surface with good bioactivity. In the invention, a uniform multi-layer pore oxidation film is quickly formed on the surface of the titanium substrate to obtain nano porous morphology; and by enabling a thin layer of protein analogue (polydopamine) to tightly adhere to the surface, the surface hydrophilicity and the corrosion resistance of the dental implant can be improved. Finally, the hydroxyapatite deposition is induced on the surface to obtain a three-layer composite surface; moreover, the nano porous composite surface can effectively reinforce the adhesion and spreading of osteoblast on the implant surface as well as the alkaline phosphatase activity, early bone integration of the implant is accelerated, and firm combination of the material and the organism interface is realized so as to improve the stability and success rate of the implant.

Description

Technical field [0001] The invention relates to the field of dental implant materials, in particular to a method for preparing a nano-porous composite bioactive surface dental implant. Background technique [0002] Oral implant materials refer to biological materials implanted into the oral and maxillofacial tissues to replace missing teeth, missing bone tissue, and bone tissue deformity correction to restore the patient's physical appearance and function. When implants are implanted in the human body, the physical and chemical properties and surface structure of the material surface will significantly affect cell adhesion, extension, growth, proliferation, and cell activity and orientation. Titanium and titanium alloys have good mechanical properties and certain biocompatibility, which makes them widely used in clinical applications. However, titanium is a biologically inert material, and it still does not have biological functions. It will corrode on the surface after long-term...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/30A61L27/06A61L27/50
CPCA61L27/34A61L27/06A61L27/306A61L27/32A61L27/50A61L2400/18A61L2430/12C08L79/02
Inventor 董超芳章彦娴王喆肖葵张达威李晓刚杨瑟飞
Owner UNIV OF SCI & TECH BEIJING
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