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Blood dialysis membrane and preparation method thereof

A technology of hemodialysis and collagen, applied in the field of hemodialysis membrane and its preparation, can solve the problems of poor barrier effect and high price of polymer membrane, and achieve good water permeability, good permeability, good bacteria and virus barrier effect of effect

Inactive Publication Date: 2016-05-25
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the price of polymer membranes for hemodialysis is relatively high, and membrane materials with good permeability to solutes have poor barrier effects on bacteria and viruses, so they cannot meet the urgent needs of clinical practice.

Method used

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  • Blood dialysis membrane and preparation method thereof

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Effect test

Embodiment 1

[0025] A hemodialysis membrane, which is mainly made of the following raw materials in proportion by mass: 21 parts of collagen, 16 parts of silk protein, 8 parts of silk fibroin, 7 parts of sericin, 11 parts of cellulose, 2 parts of polyethersulfone, 2 parts of sulfonated polyethersulfone, 7 parts of heparin, 3 parts of lysine, 4 parts of cellulose acetate, 9 parts of methyl acrylate, 14 parts of polyacrylamide, 2 parts of sodium bicarbonate, 32 parts of deionized water.

[0026] A preparation method for a hemodialysis membrane, comprising the following steps:

[0027] (1) Dissolve sodium bicarbonate in deionized water, adjust the pH to 8.2 after completely dissolving; add collagen, silk protein, silk fibroin and sericin, stir to dissolve and store at 4°C for 10 minutes;

[0028] (2) Put cellulose, polyethersulfone, sulfonated polyethersulfone, heparin, lysine, cellulose acetate, methyl acrylate and polyacrylamide in a reaction kettle at a temperature of 480°C and a pressure ...

Embodiment 2

[0032] A hemodialysis membrane, mainly made of the following raw materials according to the ratio of parts by mass: 39 parts of collagen, 34 parts of silk protein, 15 parts of silk fibroin, 11 parts of sericin, 22 parts of cellulose, 12 parts of polyethersulfone, 5 parts of sulfonated polyethersulfone, 19 parts of heparin, 12 parts of lysine, 9 parts of cellulose acetate, 18 parts of methyl acrylate, 23 parts of polyacrylamide, 8 parts of sodium bicarbonate, 54 parts of deionized water.

[0033] A preparation method for a hemodialysis membrane, comprising the following steps:

[0034] (1) Dissolve sodium bicarbonate in deionized water, adjust the pH to 9.2 after completely dissolving; add collagen, silk protein, silk fibroin and sericin, stir and dissolve, store at 6°C for 23 minutes;

[0035] (2) Put cellulose, polyethersulfone, sulfonated polyethersulfone, heparin, lysine, cellulose acetate, methyl acrylate and polyacrylamide in a reaction kettle at a temperature of 725°C an...

Embodiment 3

[0039] A hemodialysis membrane, mainly made of the following raw materials according to the mass ratio: 55 parts of collagen, 42 parts of silk protein, 19 parts of silk fibroin, 15 parts of sericin, 25 parts of cellulose, 15 parts of polyethersulfone, 7 parts of sulfonated polyethersulfone, 22 parts of heparin, 13 parts of lysine, 11 parts of cellulose acetate, 22 parts of methyl acrylate, 29 parts of polyacrylamide, 11 parts of sodium bicarbonate, 60 parts of deionized water.

[0040] A preparation method for a hemodialysis membrane, comprising the following steps:

[0041] (1) Dissolve sodium bicarbonate in deionized water, adjust the pH to 9.6 after completely dissolving; add collagen, silk protein, silk fibroin and sericin, stir to dissolve and store at 8°C for 26 minutes;

[0042] (2) Put cellulose, polyethersulfone, sulfonated polyethersulfone, heparin, lysine, cellulose acetate, methyl acrylate and polyacrylamide in a reaction kettle at a temperature of 760°C and a pres...

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Abstract

The invention discloses a blood dialysis membrane and a preparation method thereof. The blood dialysis membrane is mainly prepared from the following raw materials by mass: 21-55 parts of collagen, 16-42 parts of silk protein, 8-19 parts of fibroin, 7-15 parts of sericin, 11-25 parts of cellulose, 2-15 parts of polyethersulfone, 2-7 parts of sulfonated polyethersulfone, 7-22 parts of heparin, 3-13 parts of lysine, 4-11 parts of cellulose acetate, 9-22 parts of methyl acrylate, 14-29 parts of polyacrylamide, 2-11 parts of sodium bicarbonate, and 32-60 parts of deionized water. Compared with the prior art, the blood dialysis membrane provided by the invention has the advantages that: (1) the blood dialysis membrane prepared by the invention has good permeability to a to-be-removed solute, and also has high interception rate to protein in blood; (2) the blood dialysis membrane prepared by the invention has good bacteria and virus obstruction effect, and also has good water permeability; (3) the blood dialysis membrane prepared by the invention has does not cause blood coagulation reaction and pyrogen reaction; and (4) the blood dialysis membrane prepared by the invention has good compatibility with blood, and has moderate mechanical strength.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a hemodialysis membrane and a preparation method thereof. Background technique [0002] As we all know, due to the instinct of the organism itself to reject the invasion of foreign matter, when the artificial organ material comes into contact with the organism, a series of foreign body reactions will occur in the organism, stimulating the abnormal development of tissue cells, and even generating tumors and carcinogenesis. In order to prevent tissue cell necrosis and artificial organs from aging and decomposing and deteriorating under the action of biological body fluids and blood, the polymer materials for artificial organs must meet the following conditions: high purity, free of impurities harmful to the human body; Compatibility, that is, histocompatibility and blood compatibility, does not cause any damage to human tissue during the compatibility process, and is resistant t...

Claims

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Application Information

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IPC IPC(8): B01D69/02B01D67/00B01D71/06A61M1/16
Inventor 金仲恩全春兰张帆喻国贞欧阳智琨陈晋纳
Owner SUZHOU COSMETIC MATERIALS
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