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Method for preparation of controlled pore size biphasic calcium phosphate composite ceramic scaffold

A composite ceramic and calcium-phosphorus technology, which is applied in the field of biomedical nanomaterials, can solve the problem that a dual-phase calcium-phosphorus ceramic stent does not have a better solution, and achieves the effects of strong practicability, controllable pore size, and simple process

Inactive Publication Date: 2016-02-03
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no better solution for the control of the pore size of the dual-phase calcium-phosphorus ceramic scaffold

Method used

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  • Method for preparation of controlled pore size biphasic calcium phosphate composite ceramic scaffold
  • Method for preparation of controlled pore size biphasic calcium phosphate composite ceramic scaffold
  • Method for preparation of controlled pore size biphasic calcium phosphate composite ceramic scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1, using calcium nitrate as the calcium source, sodium dihydrogen phosphate as the phosphorus source, and the calcium to phosphorus ratio being 1.67 and 1.5, respectively preparing nano-hydroxyapatite and nano-β-tricalcium phosphate powder;

[0027] Step 2, uniformly mixing 0.2 g of prepared nano-hydroxyapatite with 0.4 g of nano-β-tricalcium phosphate powder, 0.5 g of sodium lauryl sulfate and 0.2 g of polyethylene, ball milling, and passing through a 100-mesh sieve;

[0028] Step 3, drop 1mL of ammonium bicarbonate aqueous solution into the powder obtained in step 2, stir to make it into a viscous slurry, and dry it at room temperature for 40 minutes to obtain a ceramic embryo;

[0029] Step 4: Foam the ceramic body at 45°C for 60 minutes, dehydrate it at 80°C for 120 minutes, then raise the temperature to 1000°C at a rate of 5°C / min, and remove the surfactant, pore-forming agent and foaming agent to obtain Porous biphasic calcium-phosphorus composite ceramic sca...

Embodiment 2

[0031] Step 1, using calcium hydroxide as the calcium source, phosphoric acid as the phosphorus source, and the calcium to phosphorus ratio being 1.67 and 1.5, respectively preparing nano-hydroxyapatite and nano-β-tricalcium phosphate powder;

[0032] Step 2, uniformly mix 0.4g of prepared nano-hydroxyapatite with 0.4g of nano-β-tricalcium phosphate powder, 0.7g sodium dodecylsulfonate and 0.1g polystyrene, grind in a mortar, pass 80 Mesh sieve;

[0033] Step 3, drop 1.5mL ammonium bicarbonate aqueous solution into the powder obtained in step 2, stir to make it a viscous slurry, and dry it at room temperature for 30 minutes to obtain a ceramic green body;

[0034] Step 4: Foam the ceramic body at 40°C for 80 minutes, dehydrate it at 90°C for 100 minutes, then raise the temperature to 900°C at a rate of 2°C / min, and remove the surfactant, pore-forming agent and foaming agent to obtain Porous biphasic calcium-phosphorus composite ceramic scaffold.

Embodiment 3

[0036] Step 1, using calcium chloride as the calcium source, diammonium hydrogen phosphate as the phosphorus source, and the calcium to phosphorus ratio being 1.67 and 1.5, respectively preparing nano-hydroxyapatite and nano-β-tricalcium phosphate powder;

[0037] Step 2, uniformly mix 0.6g of prepared nano-hydroxyapatite with 0.4g of nano-beta-tricalcium phosphate powder, 0.6g sodium lauryl sulfate and 0.3g polymethyl methacrylate, ball mill, pass 80 Mesh sieve;

[0038] Step 3, drop 1mL of ammonium bicarbonate aqueous solution into the powder obtained in step 2, stir to make it into a viscous slurry, and dry it at room temperature for 45 minutes to obtain a ceramic embryo;

[0039] Step 4: foam the ceramic body at 50°C for 30 minutes, dehydrate it at 95°C for 60 minutes, then raise the temperature to 1100°C at a heating rate of 10°C / min, and remove the surfactant, pore-forming agent and foaming agent to obtain Porous biphasic calcium-phosphorus composite ceramic scaffold.

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Abstract

The present invention discloses a method for preparation of a controlled pore size biphasic calcium phosphate composite ceramic scaffold. Firstly, nano-hydroxyapatite and nano-beta-tricalcium phosphate powder are prepared, the nano powder and a surfactant and a pore-forming agent are uniformly mixed, ground and sieved, added dropwise with a foaming agent solution, stirred into stick viscous slurry, and dried in air at room temperature to obtain a ceramic blank, the ceramic blank is foamed at a certain temperature and dehydrated, and sintered at high temperature, and after removal of the surfactant, the pore-forming agent and the foaming agent, the porous biphasic calcium phosphate ceramic composite scaffold can be obtained. The method is simple in process and strongly practical, by regulating of the use amount of the surfactant, the pore-forming agent and the foaming agent, the porous biphasic calcium phosphate ceramic composite scaffold can be controlled in pore size, even in distribution, and conductive to the practical application in biological medicines.

Description

technical field [0001] The invention relates to a method for preparing a ceramic support, in particular to a method for preparing a dual-phase calcium-phosphorus composite ceramic support with controllable aperture, and belongs to the technical field of biomedical nanomaterials. Background technique [0002] In the 1970s, a large number of calcium-phosphorus ceramic scaffold materials were discovered, such as hydroxyapatite (hydroxyapatite, HA), β-tricalciumphosphate (β-tricalciumphosphate, β-TCP) and so on. Calcium-phosphorus ceramic scaffold materials are bioactive materials with chemical composition and mechanical properties similar to human bone structure, so they have excellent biocompatibility, and can gradually degrade after implanted in the human body to induce osteoblast growth. , to speed up the process of autogenous bone formation. With the slow degradation of the implant and the induction of autogenous bone growth, the purpose of complete repair is finally achie...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/56
Inventor 杨志汤雪辉张薇苏言杰张亚非
Owner SHANGHAI JIAO TONG UNIV
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