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Biological coating based on cyclomatrix-type polyphosphazene and preparing method thereof

A bio-coating and polyphosphazene technology, applied in coatings, anti-corrosion coatings, etc., can solve the problems of functional monomer limitations, achieve high reaction efficiency, simple preparation conditions, and good biocompatibility

Inactive Publication Date: 2016-01-20
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology can only achieve one-dimensional preparation, and the functional monomer is limited to BPS

Method used

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  • Biological coating based on cyclomatrix-type polyphosphazene and preparing method thereof
  • Biological coating based on cyclomatrix-type polyphosphazene and preparing method thereof
  • Biological coating based on cyclomatrix-type polyphosphazene and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The ring-crosslinked polyphosphazene is applied to the surface modification of the topological honeycomb polystyrene material. This example is implemented under the conditions of implementation and technical requirements.

[0033] 1. If figure 1 and Figure 5 Shown is the process of preparing polyphosphazene coating on topological honeycomb polystyrene surface:

[0034] 1) Dissolve 1 g of polystyrene in 20 mL of toluene, and prepare a honeycomb porous polystyrene membrane on a clean glass substrate according to the breathing pattern method provided in the literature [EscaleP. etal, European Polymer Journal 2012, 6, 1001] for future use.

[0035] 2) 4,4-dihydroxydiphenyl sulfone is used as a multifunctional monomer.

[0036] 3) Weigh 20mg of hexachlorocyclotriphosphazene and 44mg of 4,4‐dihydroxydiphenylsulfone, the molar ratio is (1:3), dissolve in 8mL of absolute ethanol, and disperse evenly by ultrasonic.

[0037] 4) Place the pre-prepared topological honeycomb pol...

Embodiment 2

[0051] The ring-crosslinked polyphosphazene is applied to the surface modification of polystyrene materials. This example is implemented under the conditions of implementation and technical requirements.

[0052] 1. The process of preparing polyphosphazene coating on polystyrene surface:

[0053] 1) Dissolve 1 g of polystyrene in 20 mL of toluene, and drop the obtained solution on a clean glass substrate to prepare a polystyrene film for future use.

[0054] 2) 4,4-dihydroxydiphenyl sulfone is used as a multifunctional monomer.

[0055] 3) Weigh 20 mg of hexachlorocyclotriphosphazene and 43 mg of 4,4‐dihydroxydiphenyl sulfone in a molar ratio of (1:3), dissolve them in 8 mL of absolute ethanol, and disperse evenly by ultrasonication.

[0056] 4) Place the pre-prepared polystyrene in a clean glass petri dish, add the solution in step 3) into the petri dish, and ensure that the solution completely submerges the substrate.

[0057] 5) Add 200 μL of anhydrous triethylamine as an...

Embodiment 3

[0068] The ring-crosslinked polyphosphazene is applied to the surface modification of polyethylene materials. This example is implemented under the conditions of implementation and technical requirements.

[0069] 1. The process of preparing polyphosphazene coating on polyethylene surface:

[0070] 1) Buy a polyethylene board and keep it as a spare.

[0071] 2) 4,4-dihydroxydiphenyl sulfone is used as a multifunctional monomer.

[0072] 3) Weigh 20 mg of hexachlorocyclotriphosphazene and 43 mg of 4,4‐dihydroxydiphenyl sulfone in a molar ratio of (1:3), dissolve them in 8 mL of absolute ethanol, and disperse evenly by ultrasonication.

[0073] 4) Place the pre-prepared polyethylene in a clean glass petri dish, add the solution in step 3) into the petri dish, and ensure that the solution completely submerges the substrate.

[0074] 5) Add 200 μL of anhydrous triethylamine as an acid-binding agent, and cover the lid of the culture dish.

[0075] 6) Stir at room temperature for...

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Abstract

The invention provides a biological coating based on cyclomatrix-type polyphosphazene and a preparing method thereof. Phosphonitrilic chloride trimer and a polyfunctional group functional monomer containing an amino group and a hydroxyl group are dissolved into organic solvent, then a material to be modified is placed into a solution, an acid-binding agent is added, and the cross-linking reaction is carried out to obtain the coating modified by cyclomatrix-type polyphosphazene. The polyphosphazene coating technology is a method which is easy to realize and improves traditional macromolecule biocompatibility and corrosion resistance of metal alloy equipment, and the method is expected to play a role in the field of clinical medicine and biological scaffolds.

Description

technical field [0001] The invention relates to a technology in the field of high molecular biomaterials, in particular to a coating method based on ring-crosslinked polyphosphazene to improve the biocompatibility and mechanical properties of materials. Background technique [0002] Artificial medical materials, especially those in direct or indirect contact with tissues, need to consider the biocompatibility of materials. Biocompatibility specifically includes biotoxicity, irritation, teratogenicity, pathogenicity and bioadhesion. Different applications have different requirements for material biocompatibility. A single-component medical material is not enough to meet practical requirements, and it is often necessary to modify the surface of the material to improve its biocompatibility. [0003] 1. Overview of polymer surface biocompatibility research [0004] Commonly used medical polymer materials include polyurethane, silicone rubber, polyester fiber, polyvinylpyrroli...

Claims

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Application Information

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IPC IPC(8): C09D185/02C09D5/08C08G79/02
Inventor 路庆华陈双双陆学民
Owner SHANGHAI JIAO TONG UNIV
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