Immunologic adjuvant and vaccine containing immunologic adjuvant
An immune adjuvant and immune vaccine technology, which is applied in the field of immune adjuvants and vaccines containing the immune adjuvant, can solve the problems of flocculation, poor adjuvant stability, unfavorable production and practical application, etc.
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[0081] Preparation and performance verification of immune adjuvant and immune vaccine of the present invention
[0082] 1. Adjuvant DDA and PolyI:C adjuvant screening
[0083] DDA is a cationic liposome, which self-assembles into a liposome when the temperature is heated to a gel liquid higher than its phase transition temperature, and the liposome in the complex cationic gel state and the oppositely charged polymyocyte PolyI:C usually Lead to high instability, easy to form flocculation phenomenon. This patent improves the stability of the adjuvant DDA and PolyI:C by adding different auxiliary materials to stabilize the adjuvant DDA and PolyI:C.
[0084]In the selection of different excipients, we selected excipients such as Tween 80, Span 85, gelatin, cholesterol, lecithin, β-cyclodextrin, PLGA and other excipients, and tested their effect on the particle size and Zeta potential. Improved effect of adjuvants DDA and PolyI:C. The liposomes formed by adding different adjuvan...
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