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A kind of method for preparing drug sustained-release material

A technology for drug preparation and sustained release, which is applied in the field of biodegradable polymer drug sustained release material preparation, can solve the problems of difficult to flexibly and effectively control the dosing scheme, and difficult to meet the release requirements of drugs with different solubility properties, and achieves broad industrialization and market. Prospects, product quality indicators are stable, and the effect of improving mechanical properties

Active Publication Date: 2016-02-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above studies can overcome the problems such as the difficulty of solvent removal caused by the preparation of drug-loaded materials by the solution method, most of them are homogeneous systems, and it is difficult to flexibly and effectively control the dosing regimen, and it is difficult to meet the release requirements of drugs with different solubility properties.

Method used

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  • A kind of method for preparing drug sustained-release material
  • A kind of method for preparing drug sustained-release material
  • A kind of method for preparing drug sustained-release material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A polycaprolactone (matrix) / polyethylene oxide (disperse phase) drug sustained-release composite material comprises the following components and contents in parts by weight:

[0061]

[0062] Explanation: the weight of cephalexin (being a drug) is 1% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0063] The first step, at first prepare raw materials by above-mentioned components;

[0064] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0065]In the third step, the dried cephalexin, polycaprolactone and polyethylene oxide obtained in the second step are placed in a high mixer and premixed for 5 minutes at a speed of 100 rpm to obtain a drug and polymer premix , dry the premixed composite particles in a vacuum oven at 50°C for 3 hours.

[0066] In the fourth step, the drug and the polymer premix obtained in the third step are put into figure 1 The single-screw extruder 1 of the integrated biaxially st...

Embodiment 2

[0071] A polylactic acid (matrix) / polyethylene oxide (dispersed phase) drug sustained-release composite material comprises the following components and their contents in parts by weight:

[0072]

[0073] Explanation: the weight of diclofenac sodium (being a medicine) is 5% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0074] The first step, at first prepare raw materials by above-mentioned components;

[0075] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0076] In the third step, the dried diclofenac sodium, polylactic acid and polyethylene oxide obtained in the second step are premixed together in a high-speed mixer for 5 minutes at a speed of 100 rpm to obtain a drug and polymer premix. Then put the obtained drug and polymer premix into a twin-screw extruder for melt blending, extrusion, and granulation to obtain premixed composite granules of polylactic acid / polyethylene oxide / diclofenac sodium, and ...

Embodiment 3

[0081] A polycaprolactone-polylactic acid (matrix) / polyethylene oxide (disperse phase) drug sustained-release composite material comprises the following components and contents by weight:

[0082]

[0083] Explanation: the weight of ibuprofen cephalexin (being medicine) is 20% of the total weight of the biodegradable polymer matrix 1-2 and the dispersed phase.

[0084] The first step, at first prepare raw materials by above-mentioned components;

[0085] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0086] In the third step, the dried ibuprofen, polycaprolactone, and polylactic acid obtained in the second step are put into a twin-screw extruder for melt blending, extrusion, and granulation to obtain premixed granules of medicine and polymer. The mixed composite particles were dried in a vacuum oven at 50°C for 3 hours, and the temperatures of the feeding port, conveying section, melting section, homogenizing section, and die of the twin-screw ...

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Abstract

The invention relates to a method for preparing a drug slow-release composite material. The main content of the invention is to use a biodegradable polymer as a matrix and a dispersed phase, and combine 50-99% by weight: 50-1% of the biodegradable polymer matrix and The dispersed phase, and the drug based on 0.01% to 40% of the total weight of the biodegradable polymer mixture are melted and mixed through the extruder of the multi-stage biaxial stretching mixing and granulation integrated device to realize the biodegradable polymer blend loaded with drugs The structure of the polymer is customized to prepare a polymer drug-loaded matrix with flexible and controllable release performance to meet different drug release requirements. The method is a continuous production process, which is beneficial to the improvement of production efficiency; the process is simple, the product quality index between different batches is stable, large-scale industrial production is possible, the application range is wide, and it has broad industrialization and market prospects.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable polymer drug sustained-release material, more specifically to a method for preparing a melt blending preparation with adjustable structure, designable performance, continuous production, and flexible and controllable drug release behavior. The invention discloses a method for biodegrading polymer drug slow-release materials, belonging to the technical field of functional composite materials. Background technique [0002] Drug sustained-release preparations are also called sustained released drug delivery systems. Compared with traditional drug delivery systems, they do not require frequent administration and can maintain effective drug concentrations in the body for a long time, which can greatly improve drug efficacy and reduce toxicity. side effect. Drug-loaded materials are generally divided into two types: non-biodegradable materials and biodegradable materials. Among them, biodegrad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/34A61K47/36A61K47/32B29C47/58B29C47/92B29C48/50B29C48/525B29C48/92
CPCB29B7/46B29B7/72B29B7/7461B29B9/06B29B9/12B29C48/397B29C48/92B29C2948/92704B29C48/395B29C48/625B29C2948/92828B29C48/525
Inventor 郭少云陈蓉张聪
Owner SICHUAN UNIV
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