Dabigatran etexilate liposome
A technology of dabigatran etexilate and gatran etexilate, applied in the pharmaceutical field, can solve the problem that the drug effect can only last for a few days
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Embodiment 1
[0017] The preparation of embodiment 1 dabigatran etexilate liposome
[0018] Dissolve 1000g of lecithin and 100g of cholesterol in 2000ml of organic solvent (acetone: dichloromethane = 1:1), place on a rotary thin film evaporator to remove the organic solvent under reduced pressure to obtain a phospholipid film. Add the solution 1000ml that is dissolved in 100g dabigatran etexilate, mix well. Ultrasound at 70°C for 60 minutes. The solution was spray-dried to obtain dabigatran etexilate liposomes.
[0019] Get above-mentioned 100g dabigatran etexilate liposome, pulverize and cross 80 mesh sieves. Add 200g of starch, 10g of croscarmellose sodium, mix well, add 50ml of 30% ethanol solution containing 2g of povidone K30 to make soft material, pass through a 20 mesh sieve to granulate, dry at 60 degrees, add stearic acid Magnesium 8g, mixed evenly, and pressed into tablets.
Embodiment 2
[0020] The preparation of embodiment 2 dabigatran etexilate liposomes
[0021] Dissolve 500g of lecithin and 10g of cholesterol in 1500ml of organic solvent (acetone: dichloromethane = 1:1), place on a rotary thin film evaporator to remove the organic solvent under reduced pressure to obtain a phospholipid film. Add the solution 600ml that is dissolved in 10g dabigatran etexilate, mix well. Ultrasound at 70°C for 60 minutes. The solution was spray-dried to obtain dabigatran etexilate liposomes.
[0022] Get above-mentioned 100g dabigatran etexilate liposome, pulverize and cross 80 mesh sieves. Add 300g of microcrystalline cellulose and 10g of croscarmellose sodium, mix well, add 80ml of 2% hypromellose in 20% ethanol solution to make soft material, pass through a 20-mesh sieve to granulate, and dry at 60 degrees. Sieve through a 20-mesh sieve, add 4g of talcum powder, mix evenly, fill capsules, and get ready.
Embodiment 3
[0023] The preparation of embodiment 3 dabigatran etexilate liposomes
[0024] Dissolve 300g of lecithin and 50g of cholesterol in 1000ml of organic solvent (acetone: dichloromethane = 1:1), place on a rotary thin film evaporator to remove the organic solvent under reduced pressure to obtain a phospholipid film. Add the solution 600ml that is dissolved in 10g dabigatran etexilate, mix well. Ultrasound at 70°C for 60 minutes. The solution was spray-dried to obtain dabigatran etexilate liposomes.
[0025] Get above-mentioned 100g dabigatran etexilate liposome, pulverize and cross 80 mesh sieves. Add 100g of powdered cellulose, 10g of low-substituted hydroxypropyl cellulose, mix well, add 50ml of 30% ethanol solution containing 2g of starch to make soft material, pass through a 20-mesh sieve to granulate, dry at 60 degrees, add 2g of magnesium stearate , mix evenly, and press into tablets.
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