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Tamoxifen citrate dropping pill

A technology of tamoxifen and citric acid, applied in organic active ingredients, non-active ingredients of polymer compounds, pharmaceutical formulations, etc., can solve problems such as low bioavailability and poor stability

Active Publication Date: 2014-01-08
NANTONG GUANGTAI BIOCHEM PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the shortcomings of poor stability and low bioavailability of existing tamoxifen citrate preparations, the present invention has invented tamoxifen citrate inclusion compound sustained-release dropping pills

Method used

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  • Tamoxifen citrate dropping pill
  • Tamoxifen citrate dropping pill
  • Tamoxifen citrate dropping pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prescription for dropping pills is (by weight):

[0028] Tamoxifen citrate inclusion complex (tamoxifen citrate:α-cyclodextrin ratio 1:2) 4.7g

[0029] Mixture of poloxamer, polyethylene glycol 8000 and stearic acid (the weight ratio of the three is 5:1:3) 12.5g

[0030] The composition of sodium sulfite and sodium phosphate (the weight ratio of the two is 1.3:2.2) 0.4g

[0031] The condensate is simethicone.

[0032] Preparation:

[0033] 1. Prepare tamoxifen citrate inclusion compound according to the following method:

[0034] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in proportion, filter the resulting solution through a microporous membrane until clear, and separate the clathrate from the mixture ;or

[0035] (2) In solid form, reacting tamoxifen citrate with alpha-cyclodextrin; or

[0036] (3) Tamoxifen citrate reacts with α-cyclodextrin for high-energy grinding.

[0037] 2. Grind tamoxifen citrate inclusion com...

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Abstract

The invention relates to a dropping pill, and particularly relates to a slow-release dropping pill containing tamoxifen citrate clathrates. The tamoxifen citrate is a clathrate with alpha-cyclodextrin as a clathration material, and the weight ratio of tamoxifen citrate to the clathration material is 1:2; the slow-release dropping pill comprises tamoxifen citrate clathrates, a mixture of poloxamer, polyethylene glycol 800, and stearic acid, and a composition of sodium hydrosulphite and sodium phosphate; the condensate liquid is dimethicone.

Description

technical field [0001] The present application relates to a dropping pill, specifically, a sustained-release dropping pill containing a tamoxifen citrate inclusion compound. Background technique [0002] Dropping pills have the following characteristics: 1. Simple equipment, convenient operation, beneficial to labor protection, short process cycle and high productivity; 2. Easy to control process conditions, stable quality, accurate dosage, short heating time, easy to oxidize and volatile After the medicine dissolves in the matrix, its stability can be increased; 3, the matrix holds a large amount of liquid medicine, so the liquid medicine can be solidified; 4, the drop pill prepared by solid dispersion technology has the characteristics of rapid absorption and high bioavailability. [0003] Inclusion compounds have the following advantages: mask bad odor and reduce irritation; increase drug dissolution and bioavailability; improve drug stability. [0004] Tamoxifen (TAM) i...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/138A61K47/40A61P35/00
Inventor 李申李春涛邱俊
Owner NANTONG GUANGTAI BIOCHEM PROD
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