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Thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere and preparation method thereof

A technology of molecularly imprinted microspheres and levosulpiride, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve problems such as poor solubility, and achieve low production costs and simple preparation processes Effect

Inactive Publication Date: 2013-09-25
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on sulpiride mainly focuses on clinical application, pharmacological effects, and adverse reactions. In addition, chiral resolution, drug delivery system, and dosage forms have also been reported. The research, enrichment, and separation methods have attracted much attention, but there are few reports on molecular imprinting technology

Method used

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  • Thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere and preparation method thereof
  • Thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere and preparation method thereof
  • Thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Fe 3 o 4 Surface modification of microspheres: take 3.0g black Fe 3 o4 powder, added to 200mL of 0.5mmol / L sodium citrate solution through nitrogen and deoxygenation, and Fe 3 o 4 The powder is fully dispersed to obtain evenly dispersed Fe 3 o 4 aqueous dispersion, and then stirred at 60 °C for 12 h in a nitrogen atmosphere. Finally, after the system was cooled to room temperature, the product was separated by a magnet, washed once with acetone and redispersed directly in 100 mL deionized water to obtain about 30 mg / mL aqueous Fe 3 o 4 ferrofluid.

[0025] 2.Fe 3 o 4 SiO 2 Synthesis of microspheres: Take 10.0 mL of the modified dispersion, disperse it in a mixture of 60 mL of ethanol and 15 mL of water (volume ratio 60 / 15) containing 5.0 mL of ammonia water under ultrasound, and pour it under mechanical stirring. 2.0 mL of tetraethyl orthosilicate was added dropwise, and stirred mechanically at 45° C. to react for 6 h. After the reaction, the prepared Fe ...

Embodiment 2

[0030] 1. Same as embodiment 1.

[0031] 2. Same as embodiment 1.

[0032] 3. Same as embodiment 1.

[0033] 4. Same as embodiment 1.

[0034] 5. Elution of imprinted template molecules: Ultrasonic extraction is used, the extraction solution is methanol solution, the methanol solution is changed every 30 minutes, the amount of methanol used is 100mL each time, and the total elution time is 300 minutes. After the extraction, rinse with acetone for 1 Once, remove a small amount of fine polymer fragments. Vacuum dry at 40°C for 24h.

Embodiment 3

[0036] 1. Same as embodiment 1.

[0037] 2. Same as embodiment 1.

[0038] 3. Same as embodiment 1.

[0039] 4. Preparation of temperature-sensitive magnetic levosulpiride molecularly imprinted microspheres: Take 1 mmol (0.3414 g) template molecule levosulpiride and dissolve it in a mixed solvent of 10 mL methanol and 40 mL acetonitrile, add 4 mmol (0.453 g) functional monomer N-isopropyl Acrylamide (NIPAM), oscillating in an air bath at 40°C for 2 hours to make the template molecules fully interact with the functional monomers. In a 250mL three-necked flask, 200mg Fe 3 o 4 SiO 2 - MPS particles were dispersed in 3 mL of oleic acid, ultrasonicated for 20 min, and then the previously prepared methanol / acetonitrile mixed solution of levosulpride and NIPAM and 10 mmol (1.93 mL) cross-linking agent ethylene glycol dimethacrylate (EGDMA) were added, Stir mechanically for 30 min, add 30 mL of acetonitrile solution containing 100 mg of dispersant PVP, seal the reactor, pass nitr...

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Abstract

The invention relates to the field of intelligent high polymer materials and discloses a thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere and a preparation method thereof. According to the invention, levosulpiride is used as a template molecule, N-isopropylacrylamide is used as a functional monomer, and the thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere is prepared by using surface molecular imprinting technology. The preparation method comprises the following steps: 1, surface modification of a Fe3O4 microsphere; 2, preparation of a SiO2-coated Fe3O4 microsphere by using a sol-gel method; 3, surface silanization of the SiO2-coated Fe3O4 microsphere; 4, preparation of the thermo-sensitive type magnetic levosulpiride molecularly-imprinted microsphere on the surface of the SiO2-coated Fe3O4 microsphere by using free radical polymerization; and 5, elution of the imprinting template molecule. The preparation method provided by the invention has the advantages of easiness, low cost, convenience in industrial popularization and application, etc. The prepared molecularly-imprinted microsphere has selectivity on a target molecule and is applicable to separation of enantiomers of sulpiride.

Description

technical field [0001] The invention relates to the field of intelligent polymer materials, in particular to a temperature-sensitive magnetic molecularly imprinted nano-microsphere with good adsorption and separation functions for levosulpiride molecules and a preparation method thereof. The nano-microsphere has specific adsorption for levosulpiride , which can achieve rapid separation under the action of external magnetic force, avoiding the traditional complicated processing procedures. The molecularly imprinted polymer can be applied to the chiral separation of sulpiride enantiomers. Background technique [0002] Levosulpiride is the left-handed enantiomer of sulpiride, its chemical name is: (S)-(-)N-[methyl-(1-ethyl-2-pyrrolidinyl)]-2-methoxy- 5-(aminosulfonyl)-benzamide is a benzamide antipsychotic drug used to treat schizophrenia, and is also used for intractable vomiting, peptic ulcer and dizziness and headache after traumatic brain injury. Sulpiride mainly acts on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/54C08F2/44C08K9/06C08K3/22C08K3/36C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 陈娇娇侯蔺桐傅宏俊
Owner TIANJIN POLYTECHNIC UNIV
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